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Transport-Dependent Proteolysis of SREBP
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Sensitivity to Endo-H together with Golgi localization suggests SPRING is present in the cis/medial Golgi, where the SCAP-SREBP-S1P machinery is located.
“Together with the observed localization of SPRING in the Golgi (Fig. 5b), sensitivity to Endo-H suggests that SPRING is present in the cis/medial Golgi, which is where the SCAP-SREBP-S1P machinery is located32,33.”
From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [33]
All S1P precursors reside in the ER and the mature S1P-C'/C resides in the Golgi.
“It is reported that all the S1P precursors reside in the ER and the mature S1P-C’/C resides in the Golgi (DeBose-Boyd et al., 1999).”
From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as DeBose-Boyd et al., 1999
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“Stockprevents APP from reaching the compartment where cultures of CHO-7 cells were maintained in medium A (1:1 mixturethe g-secretase resides (Naruse et al., 1998).”
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Metadata
- Authors
- DeBose-Boyd, R. A., Brown, M. S., Li, W.-P., Nohturfft, A., Goldstein, J. L., & Espenshade, P. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 99
- Issue
- 7
- Pages
- 703-712
- ISSN
- 0092-8674
- Cited by
- 288
- References
- 1
- Language
- en
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