The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Recruitment of SMC by ParB-parS Organizes the Origin Region and Promotes Efficient Chromosome Segregation
Open accessAbstract
Summary Organization and segregation of replicated chromosomes are essential components of cell division in all organisms. The Bacillus subtilis partitioning protein Spo0J (ParB) has been implicated in both processes but how it functions remains unclear. We have discovered that Spo0J bound to its origin-proximal binding sites (parS) recruits the Structural Maintenance of Chromosomes (SMC) complex to the origin. We demonstrate that the subcellular localization of the SMC complex is disrupted in the absence of Spo0J or the parS sites. Furthermore, the SMC complex co-localizes with Spo0J at the origin and insertion of parS sites near the terminus targets SMC to this position leading to defects in chromosome organization and segregation. Finally, we show that purified SMC binds Spo0J-coated DNA with higher affinity than naked DNA. These data are consistent with a model in which recruitment of SMC to the origin by Spo0J-parS organizes the origin region and promotes efficient chromosome segregation.
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Cites
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Cited by
Condensin-based chromosome organization from bacteria to vertebrates
Hirano, T. (2016) · Cell · doi:10.1016/j.cell.2016.01.033 · Cited by 389
Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus
Wang, X., Brandão, H. B., Le, T. B. K., Laub, M. T., & Rudner, D. Z. (2017) · Science · doi:10.1126/science.aai8982 · Cited by 293
Organization and segregation of bacterial chromosomes
Wang, X., Llopis, P. M., & Rudner, D. Z. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3375 · Cited by 306
Self-citationPushing and Pulling in Prokaryotic DNA Segregation
Gerdes, K., Howard, M., & Szardenings, F. (2010) · Cell · doi:10.1016/j.cell.2010.05.033 · Cited by 290
Bacterial Chromosome Organization and Segregation
Badrinarayanan, A., Le, T. B. K., & Laub, M. T. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125211 · Cited by 289
Metadata
- Authors
- Sullivan, N. L., Marquis, K. A., & Rudner, D. Z.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 137
- Issue
- 4
- Pages
- 697-707
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1970203866
- Cited by
- 278
- References
- 45
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sullivan, N. L., Marquis, K. A., & Rudner, D. Z. (2009). Recruitment of SMC by ParB-parS Organizes the Origin Region and Promotes Efficient Chromosome Segregation. Cell. https://doi.org/10.1016/j.cell.2009.04.044
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
