The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Organization and segregation of bacterial chromosomes
Open accessAbstract
The bacterial chromosome must be compacted more than 1,000-fold to fit into the compartment in which it resides. How it is condensed, organized and ultimately segregated has been a puzzle for over half a century. Recent advances in live-cell imaging and genome-scale analyses have led to new insights into these problems. We argue that the key feature of compaction is the orderly folding of DNA along adjacent segments and that this organization provides easy and efficient access for protein–DNA transactions and has a central role in driving segregation. Similar principles and common proteins are used in eukaryotes to condense and to resolve sister chromatids at metaphase.
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Cites
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898
Capturing Chromosome Conformation
Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652
Zhou, H.-X., Rivas, G., & Minton, A. P. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125817 · Cited by 2,149
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
Heidelberg, J. F., Eisen, J. A., Nelson, W. C., Clayton, R. A., Gwinn, M. L., Dodson, R. J., Haft, D. H., Hickey, E. K., Peterson, J. D., Umayam, L., et al. (2000) · Nature · doi:10.1038/35020000 · Cited by 1,870
Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids
Michaelis, C., Ciosk, R., & Nasmyth, K. (1997) · Cell · doi:10.1016/s0092-8674(01)80007-6 · Cited by 1,471
On the Regulation of DNA Replication in Bacteria
Jacob, F., Brenner, S., & Cuzin, F. (1963) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1963.028.01.048 · Cited by 1,445
Bacterial nucleoid-associated proteins, nucleoid structure and gene expression
Dillon, S. C., & Dorman, C. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2261 · Cited by 885
Robinett, C. C., Straight, A., Li, G., Willhelm, C., Sudlow, G., Murray, A., & Belmont, A. S. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.6.1685 · Cited by 720
On the structure of the folded chromosome of Escherichia coli
Worcel, A., & Burgi, E. (1972) · Journal of Molecular Biology · doi:10.1016/0022-2836(72)90342-7 · Cited by 643
Bacterial Chromosomal Loci Move Subdiffusively through a Viscoelastic Cytoplasm
Weber, S. C., Spakowitz, A. J., & Theriot, J. A. (2010) · Physical Review Letters · doi:10.1103/physrevlett.104.238102 · Cited by 633
Cited by
Chromosome organization by one-sided and two-sided loop extrusion
Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F., & Mirny, L. A. (2020) · eLife · doi:10.7554/elife.53558 · Cited by 146
The bacterial cell cycle, chromosome inheritance and cell growth.
Reyes-Lamothe, R., & Sherratt, D. J. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0212-7 · Cited by 131
The effects of polydisperse crowders on the compaction of the Escherichia coli nucleoid
(2020) · doi:10.1111/mmi.14467 · Cited by 44
Loop-extruders alter bacterial chromosome topology to direct entropic forces for segregation
Harju, J., van Teeseling, M. C. F., & Broedersz, C. P. (2024) · Nature Communications · doi:10.1038/s41467-024-49039-w · Cited by 27
“By contrast, Escherichia coli and Streptococcus pneaumoniae have no ParABS system, and instead rely on loop-extrusion for chromosome segregation [1, 21].”
Metadata
- Authors
- Wang, X., Llopis, P. M., & Rudner, D. Z.
- Venue
- Nature Reviews Genetics
- Published
- 2013-02-12
- Volume
- 14
- Issue
- 3
- Pages
- 191-203
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2022189854
- Cited by
- 306
- References
- 135
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
