The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Localization of Bacterial DNA Polymerase: Evidence for a Factory Model of Replication
Abstract
Two general models have been proposed for DNA replication. In one model, DNA polymerase moves along the DNA (like a train on a track); in the other model, the polymerase is stationary (like a factory), and DNA is pulled through. To distinguish between these models, we visualized DNA polymerase of the bacterium Bacillus subtilis in living cells by the creation of a fusion protein containing the catalytic subunit (PolC) and green fluorescent protein (GFP). PolC-GFP was localized at discrete intracellular positions, predominantly at or near midcell, rather than being distributed randomly. These results suggest that the polymerase is anchored in place and thus support the model in which the DNA template moves through the polymerase.
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Cites
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Cited by
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727
The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis
Hamon, M. A., & Lazazzera, B. A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02709.x · Cited by 444
Themes and variations in prokaryotic cell division
Margolin, W. (2000) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(00)00038-3 · Cited by 294
The bacterial cell cycle, chromosome inheritance and cell growth.
Reyes-Lamothe, R., & Sherratt, D. J. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0212-7 · Cited by 131
The nonmutagenic repair of broken replication forks via recombination
Cox, M. M. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00256-7 · Cited by 112
Metadata
- Authors
- Lemon, K. P., & Grossman, A. D.
- Venue
- Science
- Published
- 1998-11-20
- Volume
- 282
- Issue
- 5393
- Pages
- 1516-1519
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066799534
- Cited by
- 487
- References
- 1
- FWCI
- 22.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lemon, K. P., & Grossman, A. D. (1998). Localization of Bacterial DNA Polymerase: Evidence for a Factory Model of Replication. Science. https://doi.org/10.1126/science.282.5393.1516
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
