Cited by 2,214Cell death mechanisms and regulationNF-κB Signaling PathwaysDeath, Funerary Practices, and Mourning

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

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He, Sudan, Wang, Lai, Miao, Lin, Wang, Tao, Du, Fenghe, Zhao, Liping, Wang, Xiaodong·2009·Cell

DOI 10.1016/j.cell.2009.05.021

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Abstract

Smac mimetics induce apoptosis synergistically with TNF-alpha by triggering the formation of a caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). Caspase inhibitors block this form of apoptosis in many types of cells. However, in several other cell lines, caspase inhibitors switch the apoptotic response to necrosis. A genome wide siRNA screen revealed another member of the RIP kinase family, RIP3, to be required for necrosis. The expression of RIP3 in different cell lines correlates with their responsiveness to necrosis induction. The kinase activity of RIP3 is essential for necrosis execution. Upon induction of necrosis, RIP3 is recruited to RIPK1 to form a necrosis-inducing complex. Embryonic fibroblasts from RIP3 knockout mice are resistant to necrosis and RIP3 knockout animals are devoid of inflammation inflicted tissue damage in an acute pancreatitis model. These data indicate RIP3 as the determinant for cellular necrosis in response to TNF-alpha family of death-inducing cytokines.

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Self-citation
Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626
Self-citation
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513
Self-citation
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., & Vaux, D. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00009-x · Cited by 2,372
Identification of RIP1 kinase as a specific cellular target of necrostatins
Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,987

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Chen, W., Zhou, Z., Li, L., Zhong, C., Zheng, X., Wu, X., Zhang, Y., Ma, H., Huang, D., Li, W., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435545 · Cited by 272
Concepts of tissue injury and cell death in inflammation: a historical perspective
Wallach, D., Kang, T., & Kovalenko, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3561 · Cited by 266
Herpes Simplex Virus Suppresses Necroptosis in Human Cells
Guo, H., Omoto, S., Harris, P. A., Finger, J. N., Bertin, J., Gough, P. J., Kaiser, W. J., & Mocarski, E. S. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.003 · Cited by 265
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
Rickard, J. A., Anderton, H., Etemadi, N., Nachbur, U., Darding, M., Peltzer, N., Lalaoui, N., Lawlor, K. E., Vanyai, H. K., Hall, C. M., et al. (2014) · eLife · doi:10.7554/elife.03464 · Cited by 270
Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease
Rajesh, Y., & Kanneganti, T. (2022) · Cells · doi:10.3390/cells11121885 · Cited by 269
Molecular mechanisms of regulated necrosis
Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G., & Linkermann, A. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.02.006 · Cited by 258
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Tian, D., Wang, J., Zeng, X., Gu, K., Qiu, C., Yang, X., Zhou, Z., Goh, M., Luo, Y., Murata‐Hori, M., et al. (2014) · The Plant Cell · doi:10.1105/tpc.113.119255 · Cited by 257
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice
Ramachandran, A., McGill, M. R., Xie, Y., Ni, H., Ding, W., & Jaeschke, H. (2013) · Hepatology · doi:10.1002/hep.26547 · Cited by 258
Neutrophil diversity and function in health and disease
Zhang, F., Xia, Y., Su, J., Quan, F., Zhou, H., Li, Q., Feng, Q., Lin, C., Wang, D., & Jiang, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02049-y · Cited by 306
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Ting, A. T., & Bertrand, M. J. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.06.002 · Cited by 265
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
Fortes, G. B., Alves, L. S., de Oliveira, R., Dutra, F. F., Rodrigues, D., Fernandez, P. L., Souto-Padron, T., De Rosa, M. J., Kelliher, M., Golenbock, D., et al. (2012) · Blood · doi:10.1182/blood-2011-08-375303 · Cited by 246
Photoreceptor cell death and rescue in retinal detachment and degenerations
Murakami, Y., Notomi, S., Hisatomi, T., Nakazawa, T., Ishibashi, T., Miller, J. W., & Vavvas, D. G. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.08.001 · Cited by 255
Determination of apoptotic and necrotic cell death in vitro and in vivo
Berghe, T. V., Grootjans, S., Goossens, V., Dondelinger, Y., Krysko, D. V., Takahashi, N., & Vandenabeele, P. (2013) · Methods · doi:10.1016/j.ymeth.2013.02.011 · Cited by 258
Intracellular regulation of TNF activity in health and disease
Varfolomeev, E. E., & Vucic, D. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.035 · Cited by 257
RIP kinases as modulators of inflammation and immunity
He, S., & Wang, X. (2018) · Nature Immunology · doi:10.1038/s41590-018-0188-x · Cited by 250
Self-citation
The Impact of Autophagy on Cell Death Modalities
Ryter, S. W., Mizumura, K., & Choi, A. M. K. (2014) · International Journal of Cell Biology · doi:10.1155/2014/502676 · Cited by 256
RIP kinases: key decision makers in cell death and innate immunity
Humphries, F., Yang, S., Wang, B., & Moynagh, P. N. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.126 · Cited by 249
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Alvarez-Diaz, S., Dillon, C. P., Lalaoui, N., Tanzer, M. C., Rodriguez, D. A., Lin, A., Lebois, M., Hakem, R., Josefsson, E. C., O’Reilly, L. A., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.016 · Cited by 242
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
Geserick, P., Hupe, M., Moulin, M., Wong, W. W.-L., Feoktistova, M., Kellert, B., Gollnick, H. P. M., Silke, J., & Leverkus, M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904158 · Cited by 244
Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation
Chu, T.-T., Gao, N., Li, Q.-Q., Chen, P.-G., Yang, X.-F., Chen, Y.-X., Zhao, Y.-F., & Li, Y.-M. (2016) · Cell Chemical Biology · doi:10.1016/j.chembiol.2016.02.016 · Cited by 247
Autophagy in Innate and Adaptive Immunity
Xu, Y., & Eissa, N. T. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-103js · Cited by 243
Death Receptor-Ligand Systems in Cancer, Cell Death, and InflammationPreprint
Walczak, H. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008698 · Cited by 250
Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
Orzalli, M. H., & Kagan, J. C. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.05.007 · Cited by 241
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus
Jayaraman, A., Htike, T. T., James, R., Picón, C., & Reynolds, R. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01264-w · Cited by 244
The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury
Li, J., Feng, J.-M., Wang, Y., Li, X.-H., Chen, X.-X., Su, Y., Shen, Y.-Y., Chen, Y., Xiong, B., Yang, C.-H., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.241 · Cited by 236
Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death
Schenk, B., & Fulda, S. (2015) · Oncogene · doi:10.1038/onc.2015.35 · Cited by 235
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236
TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
Vanlangenakker, N., Bertrand, M. J. M., Bogaert, P., Vandenabeele, P., & Berghe, T. V. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.111 · Cited by 236
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
Yue, Y., Nabar, N. R., Shi, C.-S., Kamenyeva, O., Xiao, X., Hwang, I., Wang, M., & Kehrl, J. H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0917-y · Cited by 232
Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense
Wang, X., Li, Y., Liu, S., Yu, X., Li, L., Shi, C., He, W., Li, J., Xu, L., Hu, Z., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412767111 · Cited by 231
Self-citation
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Mukherjee, R., Mareninova, O. A., Odinokova, I. V., Huang, W., Murphy, J., Chvanov, M., Javed, M. A., Wen, L., Booth, D. M., Cane, M. C., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308553 · Cited by 233
Mechanisms of necroptosis in T cells
Ch’en, I. L., Tsau, J., Molkentin, J. D., Komatsu, M., & Hedrick, S. Μ. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110251 · Cited by 234
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Kearney, C. J., & Martin, S. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.024 · Cited by 232
TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer
Walczak, H. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01066.x · Cited by 233
The interplay of IKK , NF ‐κB and RIPK 1 signaling in the regulation of cell death, tissue homeostasis and inflammation
Kondylis, V., Kumari, S., Vlantis, K., & Pasparakis, M. (2017) · Immunological Reviews · doi:10.1111/imr.12550 · Cited by 233
Lytic cell death in metabolic liver disease
Gautheron, J., Gores, G. J., & Rodrigues, C. M. P. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.001 · Cited by 225
A Plug Release Mechanism for Membrane Permeation by MLKL
Su, L., Quade, B., Wang, H., Sun, L., Wang, X., & Rizo, J. (2014) · Structure · doi:10.1016/j.str.2014.07.014 · Cited by 229
Self-citation
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Najafov, A., Chen, H., & Yuan, J. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.03.002 · Cited by 227
Apoptosis, Autophagy, NETosis, Necroptosis, and Pyroptosis Mediated Programmed Cell Death as Targets for Innovative Therapy in Rheumatoid Arthritis
Zhao, J., Jiang, P., Guo, S., Schrodi, S. J., & He, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.809806 · Cited by 224
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Martinet, W., Coornaert, I., Puylaert, P., & Meyer, G. R. Y. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00306 · Cited by 232
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Afonso, M. B., Rodrigues, P. M., Carvalho, T., Caridade, M., Borralho, P., Cortez‐Pinto, H., Castro, R. E., & Rodrigues, C. M. P. (2015) · Clinical Science · doi:10.1042/cs20140732 · Cited by 219
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Borghi, A., Verstrepen, L., & Beyaert, R. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.03.009 · Cited by 226
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Artus, C., Boujrad, H., Bouharrour, A., Brunelle-Navas, M.-N., Hoos, S., Yuste, V. J., Lenormand, P., Rousselle, J.-C., Namane, A., England, P., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.43 · Cited by 230
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Pierdomenico, M., Negroni, A., Stronati, L., Vitali, R., Prete, E., Bertin, J., Gough, P. J., Aloi, M., & Cucchiara, S. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.403 · Cited by 223
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Zhu, K., Liang, W. P., Ma, Z., Xu, D., Cao, S., Lu, X., Liu, N., Shan, B., Qian, L., & Yuan, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0524-y · Cited by 217
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Zhang, J., & Zhong, Q. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1656-6 · Cited by 229
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Figueroa, G., Álvarez-Carrasco, P., Ortega, E., & Maldonado‐Bernal, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631821 · Cited by 231
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
Long, J. S., & Ryan, K. M. (2012) · Oncogene · doi:10.1038/onc.2012.7 · Cited by 213
The ‘complexities’ of life and death: Death receptor signalling platforms
Dickens, L. S., Powley, I. R., Hughes, M. A., & MacFarlane, M. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.04.005 · Cited by 208
Small-molecule SMAC mimetics as new cancer therapeutics
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Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
Basit, F., Cristofanon, S., & Fulda, S. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.45 · Cited by 211
A novel role for RIP1 kinase in mediating TNFα production
Christofferson, D. E., Li, Y., Hitomi, J., Zhou, W., Upperman, C., Zhu, H., Gerber, S. A., Gygi, S. P., & Yuan, J. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.64 · Cited by 207
Origin and Consequences of Necroinflammation
Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 217
Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question
Herreweghe, F. V., Festjens, N., Declercq, W., & Vandenabeele, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0283-0 · Cited by 206
Mechanisms and Models of Kidney Tubular Necrosis and Nephron Loss
Maremonti, F., Meyer, C., & Linkermann, A. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021101293 · Cited by 213
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
Meyer, G. R. Y. D., Zurek, M., Puylaert, P., & Martinet, W. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00957-0 · Cited by 221
RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival
Lau, A. N., Wang, S., Jiang, J., Haig, A. R., Pavlosky, A., Linkermann, A., Zhang, Z.-X., & Jevnikar, A. M. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12447 · Cited by 204
Molecular crosstalk between apoptosis, necroptosis, and survival signaling
Berghe, T. V., Kaiser, W. J., Bertrand, M. J. M., & Vandenabeele, P. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.975093 · Cited by 209
MLKL forms cation channels
Xia, B., Fang, S., Chen, X., Hu, H., Chen, P., Wang, H., & Gao, Z. (2016) · Cell Research · doi:10.1038/cr.2016.26 · Cited by 202
FADD: a regulator of life and death.
Tourneur, L., & Chiocchia, G. (2010) · Trends in immunology · doi:10.1016/j.it.2010.05.005 · Cited by 210
Immunopathogenesis of pancreatitis
Watanabe, T., Kudo, M., & Strober, W. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.101 · Cited by 204
Receptor-interacting protein (RIP) kinase family
Zhang, D., Lin, J., & Han, J. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.10 · Cited by 203
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
Remijsen, Q., Goossens, V., Grootjans, S., den Haute, C. V., Vanlangenakker, N., Dondelinger, Y., Roelandt, R., Bruggeman, I., Gonçalves, A. C., Bertrand, M. J. M., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.531 · Cited by 214
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Dondelinger, Y., Delanghe, T., Rojas-Rivera, D., Priem, D., Delvaeye, T., Bruggeman, I., Herreweghe, F. V., Vandenabeele, P., & Bertrand, M. J. M. (2017) · Nature Cell Biology · doi:10.1038/ncb3608 · Cited by 205
Control of Life-or-Death Decisions by RIP1 Kinase
Christofferson, D. E., Li, Y., & Yuan, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170259 · Cited by 203
Necroptosis in neurodegenerative diseases: a potential therapeutic target
Zhang, S., Tang, M., Luo, H., Shi, C.-H., & Xu, Y.-M. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.286 · Cited by 202
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
Dondelinger, Y., Delanghe, T., Priem, D., Wynosky-Dolfi, M. A., Sorobetea, D., Rojas‐Rivera, D., Giansanti, P., Roelandt, R., Gropengießer, J., Ruckdeschel, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09690-0 · Cited by 200
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Ou, L., Lin, S., Song, B., Liu, J., Lai, R., & Shao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s140526 · Cited by 203
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
Xie, Y., Zhao, Y., Shi, L., Li, W., Chen, K., Li, M., Chen, X., Zhang, H., Li, T., Matsuzawa, Y., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133264 · Cited by 202
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity
Ørning, P., & Lien, E. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0420-305r · Cited by 206
Reactive Oxygen Species in TNFα-Induced Signaling and Cell Death
Morgan, M. J., & Liu, Z.-G. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0105-0 · Cited by 203
Oxidative stress induces mitochondrial iron overload and ferroptotic cell death
Chen, Y., Guo, X., Zeng, Y., Mo, X., Hong, S., He, H., Li, J., Fatima, S., & Liu, Q. (2023) · Scientific Reports · doi:10.1038/s41598-023-42760-4 · Cited by 202
TNFα in Liver Fibrosis
Yang, Y. M., & Seki, E. (2015) · Current Pathobiology Reports · doi:10.1007/s40139-015-0093-z · Cited by 203
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Xie, T., Peng, W., Yan, C., Wu, J., Gong, X., & Shi, Y. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.044 · Cited by 196
ZBP1 mediates interferon-induced necroptosis
Yang, D., Liang, Y., Zhao, S., Ding, Y. P., Zhuang, Q., Shi, Q., Ai, T., Wu, S., & Han, J. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0237-x · Cited by 202
Anesthetic Sevoflurane Causes Neurotoxicity Differently in Neonatal Naïve and Alzheimer Disease Transgenic Mice
Lu, Y., Wu, X., Dong, Y., Xu, Z., Zhang, Y., & Xie, Z. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181d94de1 · Cited by 195
Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells
Wu, C., Zhao, W., Yu, J. Z., Li, S., Lin, L., & Chen, X. (2018) · Scientific Reports · doi:10.1038/s41598-017-18935-1 · Cited by 195
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Fauster, A., Rebsamen, M., Huber, K., Bigenzahn, J. W., Stukalov, A., Lardeau, C.-H., Scorzoni, S., Brückner, M., Gridling, M., Parapatics, K., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.130 · Cited by 198
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Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis
Zargarian, S., Shlomovitz, I., Erlich, Z., Hourizadeh, A., Ofir‐Birin, Y., Croker, B. A., Regev‐Rudzki, N., Edry‐Botzer, L., & Gerlic, M. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002711 · Cited by 194
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de Almagro, M. C., & Vucic, D. (2012) · PubMed · Cited by 190
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Linkermann, A., Hackl, M. J., Kunzendorf, U., Walczak, H., Krautwald, S., & Jevnikar, A. M. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12448 · Cited by 193
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Peter, M. E. (2011) · Nature · doi:10.1038/471310a · Cited by 191
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Lauber, K., Ernst, A., Orth, M., i, M. H., & Belka, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00116 · Cited by 200
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Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Peltzer, N., Darding, M., & Walczak, H. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.01.006 · Cited by 188
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy
Yang, H., Ma, Y., Chen, G., Zhou, H., Yamazaki, T., Klein, C., Pietrocola, F., Vacchelli, E., Souquère, S., Sauvat, A., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1149673 · Cited by 188
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Nagy, L. E., Ding, W., Cresci, G., Saikia, P., & Shah, V. H. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.035 · Cited by 186
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Necroptosis: an alternative cell death program defending against cancer
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Authors: He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Howard Hughes Medical Institute (US)
National Institute of Biological Sciences, Beijing (CN)
Corresponding author: Wang, Xiaodong
ORCID: He, Sudan
Wang, Lai
Miao, Lin
Wang, Tao
Du, Fenghe
Zhao, Liping
Wang, Xiaodong
Venue: Cell
Publisher: Elsevier BV
Published: 2009-06
Volume: 137
Issue: 6
Pages: 1100-1111
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.05.021
OpenAlex: W2052605153
Cited by: 2,214
References: 35
Citations by year: 2026: 82 · 2025: 118 · 2024: 114 · 2023: 124 · 2022: 158 · 2021: 168 · 2020: 147 · 2019: 136 · 2018: 143 · 2017: 147 · 2016: 171 · 2015: 155 · 2014: 179 · 2013: 101 · 2012: 106
FWCI: 36.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1507 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Funders: National Institutes of Health (5p01ca095471-10)
National Cancer Institute (P01 CA95471)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: RIPK3, receptor-interacting protein kinase, necrosis, TNF-α, RIPK1, IAP antagonists, caspase-8, kinase activity, acute pancreatitis, inflammation, siRNA screen
MeSH terms: Animals, Ceruletide, Humans, Mutation, Necrosis, Pancreatitis, Tumor Necrosis Factor-alpha, Protein Structure, Tertiary, RNA, Small Interfering, Cell Line, Tumor, Mice, Receptor-Interacting Protein Serine-Threonine Kinases

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

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