Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289

Caspases: Enemies Within

Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., & Vaux, D. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00009-x · Cited by 2,372

Identification of RIP1 kinase as a specific cellular target of necrostatins

Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,987

Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis

Irrinki, K. M., Mallilankaraman, K. B., Thapa, R. J., Chandramoorthy, H. C. K., Smith, F. J., Jog, N. R., Gandhirajan, R. K., Kelsen, S. G., Houser, S. R., May, M. J., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05303-11 · Cited by 105

Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice.

Liu, Z., Wu, B., Guo, Y., Zhou, Y., Fu, Z., Xu, B.-Q., Li, J., Jing, L., Jiang, J., Tang, J., et al. (2015) · Europe PMC (PubMed Central) · Cited by 105

NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function

Ghimire, L., Paudel, S., Jin, L., Baral, P., Cai, S., & Jeyaseelan, S. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007308 · Cited by 109

ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening

Xu, T., Ding, W., Ao, X., Chu, X., Wan, Q., Wang, Y., Xiao, D., Yu, W., Li, M., Yu, F., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.10.023 · Cited by 102

Current translational potential and underlying molecular mechanisms of necroptosis

Molnár, T., Mázló, A., Tslaf, V., Szöllősi, A. G., Emri, G., & Koncz, G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2094-z · Cited by 110

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

Garnish, S. E., Meng, Y., Koide, A., Sandow, J. J., Denbaum, E., Jacobsen, A. V., Yeung, W., Samson, A. L., Horne, C. R., Fitzgibbon, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22400-z · Cited by 107

Structural Basis of Signal Transduction in the TNF Receptor Superfamily

Li, J., Yin, Q., & Wu, H. (2013) · Advances in immunology · doi:10.1016/b978-0-12-407707-2.00005-9 · Cited by 115

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

Karch, J. M., Kanisicak, O., Brody, M. J., Sargent, M. A., Michael, D. M., & Molkentin, J. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130520 · Cited by 106

Key roles of necroptotic factors in promoting tumor growth

Liu, X., Zhou, M., Mei, L., Ruan, J., Hu, Q., Peng, J., Su, H., Liao, H., Liu, S., Liu, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7924 · Cited by 109

Cytokines and Pancreatic β-Cell Apoptosis

Berchtold, L. A., Prause, M. C. B., Størling, J., & Mandrup-Poulsen, T. R. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.02.001 · Cited by 104

The lipid basis of cell death and autophagy

Lin, Z., Long, F., Kang, R., Klionsky, D. J., Yang, M., & Tang, D. (2023) · Autophagy · doi:10.1080/15548627.2023.2259732 · Cited by 107

Complex Roles of Caspases in the Pathogenesis of Inflammatory Bowel Disease

Becker, C., Watson, A. J. M., & Neurath, M. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.11.035 · Cited by 107

Involvement of Alveolar Epithelial Cell Necroptosis in Idiopathic Pulmonary Fibrosis Pathogenesis

Lee, J.-M., Yoshida, M., Kim, M.-S., Lee, J.-H., Baek, A.-R., Jang, A., Kim, D.-J., Minagawa, S., Chin, S., Park, C., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0034oc · Cited by 106

The role of lysosome in regulated necrosis

Alu, A., Han, X., Ma, X., Wu, M., Wei, Y., & Wei, X. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.003 · Cited by 109

Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration

Zhou, S., Zhang, W., Cai, G., Ding, Y., Wei, C., Li, S., Yu, Y., Qin, J., Liu, D., Zhang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00393-6 · Cited by 105

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

Liu, P., Xu, B., Shen, W., Zhu, H., Wu, W., Fu, Y., Chen, H., Dong, H., Zhu, Y., Miao, K., et al. (2011) · Leukemia · doi:10.1038/leu.2011.357 · Cited by 104

Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal

Li, S., Sun, W. Y., Wang, H., Zuo, D., Hua, Y., & Cai, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-3181-0 · Cited by 104

The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis

Moriwaki, K., & Chan, F. K.-M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.08.007 · Cited by 107

RIP3 AND pMLKL promote necroptosis-induced inflammation and alter membrane permeability in intestinal epithelial cells

Negroni, A., Colantoni, E., Pierdomenico, M., Palone, F., Costanzo, M., Oliva, S., Tiberti, A., Cucchiara, S., & Stronati, L. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.08.017 · Cited by 106

The role of necroptosis in disease and treatment

Liu, X., Xie, X., Ren, Y., Shao, Z., Zhang, N., Li, L., Ding, X., & Zhang, L. (2021) · MedComm · doi:10.1002/mco2.108 · Cited by 110

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

Legarda, D., Justus, S. J., Ang, R. L., Rikhi, N., Li, W., Moran, T. M., Zhang, J., Mizoguchi, E., Zelic, M., Kelliher, M. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.032 · Cited by 104

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases

Williams, J., Manley, S., & Ding, W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12908 · Cited by 102

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

Roderick, J. E., Hermance, N. M., Zelic, M., Simmons, M. J., Polykratis, A., Pasparakis, M., & Kelliher, M. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409389111 · Cited by 101

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Lalaoui, N., Hänggi, K., Brumatti, G., Chau, D., Nguyen, N.-Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.01.006 · Cited by 102

Necroptosis Is an Important Severity Determinant and Potential Therapeutic Target in Experimental Severe Pancreatitis

Louhimo, J. M., Steer, M. L., & Perides, G. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.04.002 · Cited by 103

RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease

Lin, Q., Chen, P., Wang, W.-X., Lin, C.-C., Zhou, Y., Yu, L., Lin, Y., Xu, Y., & Kang, D.-Z. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0319-5 · Cited by 102

Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms

Gupta, A., Singh, A. K., Kumar, R., Ganguly, R., Rana, H. K., Pandey, P. K., Sethi, G., Bishayee, A., & Pandey, A. K. (2019) · Molecules · doi:10.3390/molecules24183399 · Cited by 102

Regulated Necrosis in Atherosclerosis

Puylaert, P., Zurek, M., Rayner, K. J., Meyer, G. R. Y. D., & Martinet, W. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318177 · Cited by 111

Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents?

Gielecińska, A., Kciuk, M., Yahya, E. B., Ainane, T., Mujwar, S., & Kontek, R. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189024 · Cited by 110

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

Morioka, S., Broglie, P. M., Omori, E., Ikeda, Y., Takaesu, G., Matsumoto, K., & Ninomiya‐Tsuji, J. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201305070 · Cited by 101

The complex interplay between autophagy, apoptosis, and necrotic signals promotes T‐cell homeostasis

Walsh, C. M., & Edinger, A. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00919.x · Cited by 99

Manipulation of apoptosis and necroptosis signaling by herpesviruses

Guo, H., Kaiser, W. J., & Mocarski, E. S. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0410-5 · Cited by 99

IAPs, regulators of innate immunity and inflammation

Estornes, Y., & Bertrand, M. J. M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.035 · Cited by 106

Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice

Belizário, J. E., Cordeiro, L., & Enns, S. C. (2015) · Mediators of Inflammation · doi:10.1155/2015/128076 · Cited by 106

Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer

Dineen, S. P., Roland, C. L., Greer, R. M., Carbon, J. G., Toombs, J. E., Gupta, P. K., Bardeesy, N. M., Sun, H., Williams, N. S., Minna, J. D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3892 · Cited by 98

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

Dziedzic, S. A., Su, Z., Barrett, V. J., Najafov, A., Mookhtiar, A. K., Amin, P. P., Pan, H., Sun, L., Zhu, H., Ma, A. I., et al. (2017) · Nature Cell Biology · doi:10.1038/s41556-017-0003-1 · Cited by 100

RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism

Liu, W., Chen, B., Wang, Y., Meng, C., Huang, H., Huang, X., Qin, J., Mulay, S. R., Anders, H., Qiu, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716959115 · Cited by 99

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

Li, X., Zhang, M., Huang, X., Liang, W. P., Li, G., Lu, X., Li, Y., Pan, H., Shi, L., Zhu, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19935-y · Cited by 99

Differently surface-labeled polystyrene nanoplastics at an environmentally relevant concentration induced Crohn’s ileitis-like features via triggering intestinal epithelial cell necroptosis

Xu, D., Ma, Y., Peng, C., Gan, Y., Wang, Y., Chen, Z., Han, X., & Chen, Y. (2023) · Environment International · doi:10.1016/j.envint.2023.107968 · Cited by 105

TRAF2 is a biologically important necroptosis suppressor

Petersen, S. L., Chen, T. T., Lawrence, D. A., Marsters, S. A., Gonzalvez, F., & Ashkenazi, A. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.35 · Cited by 99

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

Yang, M., Lv, Y., Tian, X., Lou, J., An, R., Zhang, Q. Y., Li, M., Xu, L., & Dong, Z. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00583 · Cited by 99

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

Gonçalves, A. V., Margolis, S. R., Quirino, G. F. S., Mascarenhas, D. P. A., Rauch, I., Doyle, R. N., Ansaldo, E., Fontana, M. F., Vance, R. E., & Zamboni, D. S. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007886 · Cited by 97

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy

Wu, W., Wang, X., Sun, Y., Berleth, N., Deitersen, J., Schlütermann, D., Stuhldreier, F., Hieke, N., Mendiburo, M. J., Cox, J., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1899667 · Cited by 98

Therapeutic exploitation of necroptosis for cancer therapy

Fulda, S. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.07.002 · Cited by 97

Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance

Lin, S., Hsieh, S., Fan, Y.-T., Wei, W., Hsiao, P., Tsai, D.-H., Wu, T., & Yang, N. (2017) · Autophagy · doi:10.1080/15548627.2017.1386359 · Cited by 96

Necroptosis-Inducing Rhenium(V) Oxo Complexes

Suntharalingam, K., Awuah, S. G., Bruno, P. M., Johnstone, T. C., Wang, F., Wei, L., Zheng, Y., Page, J. E., Hemann, M. T., & Lippard, S. J. (2015) · Journal of the American Chemical Society · doi:10.1021/ja511978y · Cited by 98

Regulation of necroptosis signaling and cell death by reactive oxygen species

Fulda, S. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0102 · Cited by 95

Immunological consequences of kidney cell death

Sarhan, M., von Mäßenhausen, A., Hugo, C., Oberbauer, R. W., & Linkermann, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0057-9 · Cited by 100

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

Wang, Y., Zhao, M., He, S., Luo, Y., Zhao, Y., Cheng, J. Q., Gong, Y., Xie, J., Wang, Y., Hu, B., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1423-5 · Cited by 100

Going up in flames: necrotic cell injury and inflammatory diseases

Challa, S., & Chan, F. K.-M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0413-8 · Cited by 100

The oncogenic microRNA miR-21 promotes regulated necrosis in mice

Ma, X., Conklin, D. J., Li, F., Dai, Z., Xiang, H., Li, Y., Xu-Monette, Z. Y., Young, K. H., Xiong, W., Wysoczynski, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8151 · Cited by 98

Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway

Su, X., Wang, H., Kang, D., Zhu, J., Sun, Q., Li, T., & Ding, K. (2015) · Neurochemical Research · doi:10.1007/s11064-014-1510-0 · Cited by 96

Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein

Yan, B., Liu, L., Huang, S., Ren, Y., Wang, H., Yao, Z., Lin, L., Chen, S., Wang, X., & Zhang, Z. (2017) · Chemical Communications · doi:10.1039/c7cc00667e · Cited by 101

Necroptosis mediates myofibre death in dystrophin-deficient mice

Morgan, J. E., Prola, A., Mariot, V., Pini, V., Meng, J., Hourdé, C., Dumonceaux, J., Conti, F. J. A., Relaix, F., Authier, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06057-9 · Cited by 97

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Tang, Y., Tu, H., Zhang, J., Zhao, X., Wang, Y., Qin, J., & Lin, X. (2019) · Nature Communications · doi:10.1038/s41467-019-12033-8 · Cited by 103

The evolution of regulated cell death pathways in animals and their evasion by pathogens

Tummers, B., & Green, D. R. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2021 · Cited by 95

Regulation of programmed cell death by Brd4

Hu, J., Pan, D., Guo, L., Chen, K., & Hu, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05505-1 · Cited by 100

Role of necroptosis in kidney health and disease

Kolbrink, B., von Samson‐Himmelstjerna, F. A., Murphy, J. M., & Krautwald, S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00658-w · Cited by 100

Decoding immunogenic cell death from a dendritic cell perspective

Janssens, S., Rennen, S., & Agostinis, P. (2023) · Immunological Reviews · doi:10.1111/imr.13301 · Cited by 106

Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity

Guo, Z., Liu, Y., Chen, D., Sun, Y., Li, D., Meng, Y., Zhou, Q., Zeng, F., Deng, G., & Chen, X. (2025) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2025-0004 · Cited by 111

Linear ubiquitination at a glance

Spit, M., Rieser, E., & Walczak, H. (2019) · Journal of Cell Science · doi:10.1242/jcs.208512 · Cited by 94

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML

Volk, A. G., Li, J., Xin, J., You, D., Zhang, J., Liu, X., Xiao, Y., Breslin, P., Li, Z., Wei, W., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130990 · Cited by 94

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

Zhang, X., Zhang, H., Xu, C., Li, M., Li, M., Pu, W., Pu, W., Zhou, B., Wang, H., Li, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11839-w · Cited by 94

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

Xu, G., Li, Y., Zhang, S., Peng, H., Wang, Y., Li, D., Jin, T., He, Z., Tong, Y., Qi, C., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00578-7 · Cited by 95

Acute Pancreatitis—Progress and Challenges

Afghani, E., Pandol, S. J., Shimosegawa, T., Sutton, R., Wu, B. U., Vege, S. S., Gorelick, F. S., Hirota, M., Windsor, J. A., Lo, S. K., et al. (2015) · Pancreas · doi:10.1097/mpa.0000000000000500 · Cited by 95

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome

Zelic, M., Roderick, J. E., O’Donnell, J. A., Lehman, J. W., Lim, S. E., Janardhan, H. P., Trivedi, C. M., Pasparakis, M., & Kelliher, M. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96147 · Cited by 93

Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury

Hu, J., Zhu, X., Zhang, X., Wang, P., Zhang, R., Zhang, P., Zhao, G., Gao, L., Zhang, X., Tian, S., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.021 · Cited by 93

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

Yamanaka, K., Urano, Y., Takabe, W., Saito, Y., & Noguchi, N. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.524 · Cited by 93

NET formation can occur independently of RIPK3 and MLKL signaling

Amini, P., Stojkov, D., Wang, X., Wicki, S., Kaufmann, T., Wong, W. W.-L., Simon, H., & Yousefi, S. (2015) · European Journal of Immunology · doi:10.1002/eji.201545615 · Cited by 97

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

Kim, H.-J., Hwang, K., Park, D., Oh, S., Jun, H. Y., Yoon, K., Jeong, E., Kim, Y. S., & Kim, Y. S. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1223-7 · Cited by 97

Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis

Guo, X., Yin, H., Li, L., Chen, Y., Li, J., Doan, J., Steinmetz, R. N., & Liu, Q. (2017) · Circulation · doi:10.1161/circulationaha.116.026240 · Cited by 93

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

Li, D., Meng, L., Xu, T., Su, Y., Liu, X., Zhang, Z., & Wang, X. (2017) · eLife · doi:10.7554/elife.27692 · Cited by 94

Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut

Garcia‐Carbonell, R., Yao, S.-J., Das, S., & Gumá, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01094 · Cited by 92

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Martens, S., Jeong, M., Tonnus, W., Feldmann, F., Hofmans, S., Goossens, V., Takahashi, N., Bräsen, J. H., Lee, E., der Veken, P. V., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.298 · Cited by 95

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

Ying, Z., Pan, C., Shao, T., Liu, L., Li, L., Guo, D., Zhang, S., Yuan, T., Cao, R., Jiang, Z., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.09.011 · Cited by 90

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux

Zhan, Q., Jeon, J., Li, Y., Huang, Y., Xiong, J., Wang, Q., Xu, T., Li, Y., Ji, F., Du, G., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1954348 · Cited by 93

RIPK3 signaling and its role in regulated cell death and diseases

Zhou, Y., Xiang, Y., Liu, S., Li, C., Dong, J., Kong, X., Ji, X., Cheng, X., & Zhang, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01957-w · Cited by 97

LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

Zinngrebe, J., Rieser, E., Taraborrelli, L., Peltzer, N., Hartwig, T., Ren, H., Kovács, I., Endres, C., Dráber, P., Darding, M., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160041 · Cited by 94

Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation

Tsuchiya, Y., Asano, T., Nakayama, K., Kato, T., Karin, M., & Kamata, H. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.030 · Cited by 91

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

Khan, N. R., Lawlor, K. E., Murphy, J. M., & Vince, J. E. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.10.017 · Cited by 93

RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression

Liu, Z., Zheng, M., Li, Y., Fan, X., Wang, J., Li, Z., Yang, H., Yu, J., Cui, J., Jiang, J., et al. (2019) · Theranostics · doi:10.7150/thno.32126 · Cited by 95

Receptor Interacting Protein Kinase-Mediated Necrosis Contributes to Cone and Rod Photoreceptor Degeneration in the Retina Lacking Interphotoreceptor Retinoid-Binding Protein

Sato, K., Li, S., Gordon, W. C., He, J., Liou, G. I., Hill, J. M., Travis, G. H., Bazan, N. G., & Jin, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1380-13.2013 · Cited by 96

Intestinal barrier homeostasis in inflammatory bowel disease

Goll, R., & Granlund, A. V. B. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.971425 · Cited by 93

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

Zhang, B., Li, M., Yin, R., Liu, Y., Yang, Y., Mitchell-Richards, K., Nam, J. H., Li, R., Wang, L., Iwakiri, Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127709 · Cited by 95

A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management

Zheng, Z., Ding, Y., Qu, Y., Cao, F., & Li, F. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4802 · Cited by 96

Proliferative versus apoptotic functions of caspase-8

van Raam, B. J., & Salvesen, G. S. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.06.005 · Cited by 90

5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma

Coupienne, I., Fettweis, G., Rubio, N., Agostinis, P., & Piette, J. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05213f · Cited by 91

Distinct Roles for the NF-κB RelA Subunit during Antiviral Innate Immune Responses

Basagoudanavar, S. H., Thapa, R. J., Nogusa, S., Wang, J., Beg, A. A., & Balachandran, S. (2011) · Journal of Virology · doi:10.1128/jvi.02213-10 · Cited by 94

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

Wang, S., Ni, H., Dorko, K., Kumer, S. C., Schmitt, T. M., Nawabi, A. M., Komatsu, M., Huang, H., & Ding, W. (2016) · Oncotarget · doi:10.18632/oncotarget.6893 · Cited by 91

Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked

Hannes, S., Abhari, B. A., & Fulda, S. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.05.036 · Cited by 91

Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma

Dinh, C. T., Goncalves, S., Bas, E., Water, T. R. V. D., & Zine, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00096 · Cited by 91

Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons

Liu, S., Wang, X., Li, Y., Xu, L., Yu, X., Ge, L., Li, J., Zhu, Y., & He, S. (2014) · BioMed Research International · doi:10.1155/2014/290182 · Cited by 89

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

Meng, M.-B., Wang, H.-H., Cui, Y.-L., Wu, Z.-Q., Shi, Y., Zaorsky, N. G., Deng, L., Yuan, Z., Lü, Y., & Wang, P. (2016) · Oncotarget · doi:10.18632/oncotarget.10548 · Cited by 91

Cell death in drug-induced liver injury

Iorga, A., & Dara, L. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.01.006 · Cited by 89

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Peng, R., Wang, C. K., Wang‐Kan, X., Idorn, M., Kjær, M., Zhou, F., Fiil, B. K., Timmermann, F., Orozco, S. L., McCarthy, J., et al. (2022) · EMBO Reports · doi:10.15252/embr.202255839 · Cited by 85

The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways

Yu, X., & He, S. (2016) · Virology Journal · doi:10.1186/s12985-016-0528-0 · Cited by 90

Necroptosis and neutrophil-associated disorders

Wang, X., Yousefi, S., & Simon, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0058-8 · Cited by 95

Biological events and molecular signaling following MLKL activation during necroptosis

Gong, Y., Guy, C. S., Crawford, J. C., & Green, D. R. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1371889 · Cited by 93

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.

Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling · doi:10.1126/scisignal.abc6178 · Cited by 82

Mitochondria in Multiple Sclerosis: Molecular Mechanisms of Pathogenesis

Patergnani, S., Fossati, V., Bonora, M., Giorgi, C., Marchi, S., Missiroli, S., Rusielewicz, T., Wieckowski, M. R., & Pinton, P. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.08.003 · Cited by 86

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-a

(2014)

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

Moujalled, D., Cook, W. D., Okamoto, T., Murphy, J. M., Lawlor, K. E., Vince, J. E., & Vaux, D. L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.201 · Cited by 155

RIP3:a Possible Trigger of Apoptosis or Necrosis

Xiao, Z. (2010) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3

Chang, X., Wang, L., Wang, Z., Wu, S., Zhu, X., Hu, S., Wang, Y., Yu, J., & Chen, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-16390-6 · Cited by 13

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

Vandenabeele, P., Declercq, W., Van Herreweghe, F., & Vanden Berghe, T. (2010) · Science Signaling · doi:10.1126/scisignal.3115re4 · Cited by 482