TRAF2 is a biologically important necroptosis suppressor

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

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Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

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TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

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RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

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Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

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The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

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TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

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Necroptosis

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cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

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The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

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CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

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Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

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MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

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Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

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RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

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Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

Newton, K., Sun, X., & Dixit, V. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1464-1469.2004 · Cited by 544 · see citing works

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

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Caspase 8 inhibits programmed necrosis by processing CYLD

O’Donnell, M. A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D. R., & Ting, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2362 · Cited by 494 · see citing works

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

Linkermann, A., Bräsen, J. H., Himmerkus, N., Liu, S., Huber, T. B., Kunzendorf, U., & Krautwald, S. (2012) · Kidney International · doi:10.1038/ki.2011.450 · Cited by 462 · see citing works

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Wu, J., Huang, Z., Ren, J., Zhang, Z., He, P., Li, Y., Ma, J., Chen, W., Zhang, Y., Zhou, X., et al. (2013) · Cell Research · doi:10.1038/cr.2013.91 · Cited by 452 · see citing works

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

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Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

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Necroptosis in health and diseases

Zhou, W., & Yuan, J. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.07.013 · Cited by 414 · see citing works

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Vanlangenakker, N., Vanden Berghe, T., Bogaert, P., Laukens, B., Zobel, K., Deshayes, K., Vucic, D., Fulda, S., Vandenabeele, P., & Bertrand, M. J. M. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.138 · Cited by 339 · see citing works

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

Moquin, D. M., McQuade, T., & Chan, F. K.-M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076841 · Cited by 320 · see citing works

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Takahashi, N., Vereecke, L., Bertrand, M. J. M., Duprez, L., Berger, S. B., Divert, T., Gonçalves, A., Sze, M., Gilbert, B., Kourula, S., et al. (2014) · Nature · doi:10.1038/nature13706 · Cited by 318 · see citing works

Anatomy of TRAF2

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Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

Mocarski, E. S., Upton, J. W., & Kaiser, W. J. (2011) · Nature reviews. Immunology · doi:10.1038/nri3131 · Cited by 300 · see citing works

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

Bonnet, M. C., Preukschat, D., Welz, P.-S., van Loo, G., Ermolaeva, M. A., Bloch, W., Haase, I., & Pasparakis, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.014 · Cited by 295 · see citing works

Regulated Cell Death: Signaling and Mechanisms

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Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

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TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Vince, J. E., Pantaki-Eimany, D., Feltham, R., Mace, P. D., Cordier, S. M., Schmukle, A. C., Davidson, A. J., Callus, B. A., Wong, W. W.-L., Gentle, I. E., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.072256 · Cited by 241 · see citing works

Necroptosis in Immunity and Ischemia-Reperfusion Injury

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RIPK1 is not essential for TNFR1-induced activation of NF-κB

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TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

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Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival

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In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8

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TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis

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MLKL regulates necrotic plasma membrane permeabilization

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Immunoadhesins as research tools and therapeutic agents

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SnapShot: Caspases

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Interferon-α enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells

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Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2 Controls Homeostasis of the Colon to Prevent Spontaneous Development of Murine Inflammatory Bowel Disease

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The Role of TRAF2 Binding to the Type I Interferon Receptor in Alternative NFκB Activation and Antiviral Response

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TRAF2-MLK3 interaction is essential for TNF-α-induced MLK3 activation

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cIAPs and XIAP reduce RIPKs to silence

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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Necroptosis: Mechanisms and Relevance to Disease

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Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy

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Oxidative stress and regulated cell death in Parkinson’s disease

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Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators

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The role of Ubiquitination in Apoptosis and Necroptosis

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TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death

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CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

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Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

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Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway

Liu, L., Liang, L., Yang, C., Zhou, Y., & Chen, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1902718 · Cited by 176 · see citing works

Poly-ubiquitination in TNFR1-mediated necroptosis

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RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

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Sublethal necroptosis signaling promotes inflammation and liver cancer

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An outline of necrosome triggers

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TRAF Molecules in Inflammation and Inflammatory Diseases

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A decade of cell death studies: Breathing new life into necroptosis

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Research trends, hot spots and prospects for necroptosis in the field of neuroscience

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Current translational potential and underlying molecular mechanisms of necroptosis

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The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis

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TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

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Necroptosis-independent signaling by the RIP kinases in inflammation

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Primary and Metastatic Melanoma With NTRK Fusions

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Genetic Alterations of TRAF Proteins in Human Cancers

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Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis

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Necroptosis: A new way of dying?

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TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis

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Identification and Validation a Necroptosis‑related Prognostic Signature and Associated Regulatory Axis in Stomach Adenocarcinoma

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TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer

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