Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

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How Shelterin Protects Mammalian Telomeres

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Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

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DNA Damage Foci at Dysfunctional Telomeres

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Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends

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In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere FunctionPreprint

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Telomere Dysfunction in Renal Tubular Epithelial Cells Leads to Kidney Fibrosis

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Structural organization and function of telomeric chromatin

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Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres

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Rare genetic diseases associated with G-quadruplex-induced replication stress

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Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity

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Inhibiting Telomerase Activity and Inducing Apoptosis in Cancer Cells by Several Natural Food Compounds

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Replication Stress and Telomere Dysfunction Are Present in Cultured Human Embryonic Stem Cells

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Spontaneous replication fork collapse regulates telomere length homeostasis in wild-type yeast

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Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR

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The role of telomere dysfunction in genomic instability and age-related diseases

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Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown

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A Novel Tissue and Stem Cell Specific TERF1 Splice Variant Is Downregulated in Tumour Cells

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Breaking the paradigm: early insights from mammalian DNA breakomes

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Murine Models of Dysfunctional Telomeres and Telomerase

Liu, Y., & Harrington, L. A. (2012) · Wiley eBooks · doi:10.1002/9781118268667.ch9 · Cited by 3

RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere FragilityPreprint

Briod, A., Glousker, G., & Lingner, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.20.912634 · Cited by 3

Induction of the ALT pathway requires loss of ATRX-DAXX in concert with genotoxic lesions at telomeresPreprint

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Telomere Protection in Stem CellsPreprint

Markiewicz-Potoczny, M., & Denchi, E. L. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041686 · Cited by 3

Association of Genetic Polymorphisms of TERT with Telomere Length in Coke Oven Emissions-Exposed Workers

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Bleomycin induces short-term telomere fragility in Epstein-Barr virus-transformed human lymphoblastoid cells

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Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity

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Ribosome collisions and ZAKα activation: explores the therapeutic potential of metabolic diseases

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Fueling for the finish line: Control of human telomerase activity by nucleotide metabolism

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BLM and FANCJ role in the response to G-quadruplex-dependent telomeric replicative stress

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Coordination of ALT telomere maintenance across the cell cycle

Vornberger, J., & Altmeyer, M. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.06.037 · Cited by 2

Comparing the Role of the p53 Gene and Telomerase Enzyme in ‘Accelerated Aging Due to Cancer’: A Literature Review

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The effect of meditation on telomerase and stem cell

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Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility

Herrera‐Moyano, E., Porreca, R. M., Ranjha, L., Skourti, E., Gonzalez-Franco, R., Stylianakis, E., Sun, Y., Li, R., Saleh, A., Montoya, A., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111096 · Cited by 2

Ustilago maydis Trf2 ensures genome stability by antagonizing Blm-mediated telomere recombination: Fine-tuning DNA repair factor activity at telomeres through opposing regulations

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Long telomere inheritance through budding yeast sexual cycles

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Extra-Telomeric Roles of Telomeric Proteins

Ghosh, A., & Tergaonkar, V. (2012) · InTech eBooks · doi:10.5772/38661 · Cited by 3

Enhanced induction of abnormal telomere FISH signals in response to oxidative DNA damage

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Resonance assignment and secondary structure of the tandem harmonin homology domains of human RTEL1

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Timeless tunes

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Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generationsPreprint

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Tetrameric TRF2 forms t-loop to protect telomeres from ATM signaling and cNHEJPreprint

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Telomeres: Structure and Function

Cohen, S. B., & Bryan, T. M. (2023) · Springer eBooks · doi:10.1007/978-981-16-1313-5_104-1 · Cited by 1

Beginning at the ends: telomere and telomere-based cancer therapeutics

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Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

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Reduced CHMP7 Expression Compromises Telomere Integrity in Mammalian Cells

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SLX4IP limits replication stress globally and at ALT telomeres

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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

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Telomeres Shortening: A Mere Replicometer?

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Telomere and Telomerase in Cancer

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High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype

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What have we learned so far on the molecular pathogenesis of Werner syndrome using mutant mouse models of this human progeroid disorder?

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CARF: A Stress, Senescence, and Cancer Regulator

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A Noncanonical Function of the Telomerase RNA Component in Human Embryonic Stem Cells

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Monitoring the replication of structured DNA through heritable epigenetic change

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The role of BRCA2 in the fragility of interstitial telomeric sites

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Rap1 prevents fusions between long telomeres in fission yeast

Pan, L., Tormey, D., Bobon, N., & Baumann, P. (2022) · The EMBO Journal · doi:10.15252/embj.2021110458 · Cited by 1

Telomeres: Structure and Function

Cohen, S. B., & Bryan, T. M. (2023) · Springer eBooks · doi:10.1007/978-981-19-9776-1_104 · Cited by 1

Parallel genetic screens identify nuclear envelope homeostasis as a key determinant of telomere entanglement resolution in fission yeast

Nageshan, R. K., Krogan, N. J., & Cooper, J. P. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae078 · Cited by 1

DNA Helicase Deficiency Disorders

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The Immunologic Complications and Genetic Origins of Telomere Disorders

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Telomerase Regulation in Arabidopsis thaliana

Nelson, A. D. L. (2012) · OakTrust (Texas A&M University Libraries) · Cited by 1

Biochemical and structural analysis of shelterin subcomplexes

Inian, O. (2018) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/75683 · Cited by 1

Proteins that interact with DNA and RNA G-quadruplexes

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Telomere relocalization to the nuclear pore complex in response to replication stressPreprint

Pinzaru, A. M., Lamm, N., Kareh, M., Denchi, E. L., Cesare, A. J., & Sfeir, A. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.31.929059 · Cited by 1

TIN2 facilitates TRF1-mediated trans - and cis -interactions on physiologically relevant long telomeric DNAPreprint

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DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeresPreprint

Ragupathi, A., Abid, H. Z., Chen, Y., Zhao, R., Kosiyatrakul, S. T., Yetil, D. I., Neiswander, J., Feltman, R., Thomas, S., Yusupov, B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.22.655602 · Cited by 1

The Conglomerate Theory of Aging: A Unified Model of Metal, AGE, and ALE AccumulationPreprint

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Identification and characterization of a TRF2-like telomere-binding protein in ArabidopsisPreprint

Fulnečková, J., Faturova, J., Fulneček, J., Pecinkova, J., Potěšil, D., Ranjani, G. S., Zdráhal, Z., & Říha, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.29.702503 · Cited by 1

The SNM1B Nuclease Plays Important Roles in Maintaining Genome Stability.

Mason, J. M. (2010) · Deep Blue (University of Michigan) · Cited by 1

Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae

Talley, J. (2011)

Control of Telomeric DNA Replication: Genetics, Molecular Biology, and Physiology

Matsuura, A., & Matsui, A. (2011) · InTech eBooks · doi:10.5772/18551

El Ying y el Yang de los telómeros: cáncer y envejecimiento

Blasco, M. A. (2010) · Anales de la Real Academia Nacional de Farmacia

Telomere Structure in Telomerase Regulation

Vodenicharov, M. D., & Wellinger, R. J. (2012) · Wiley eBooks · doi:10.1002/9781118268667.ch7

Análisis de inestabilidad telomérica en la progenie de células de rata expuestas a mutágenos químicos y en un modelo murino de inducción tumoral

Paviolo, N. S. (2015) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/44600

Polymerase alpha components associate with telomeres to mediate overhang processing

Diotti, R. (2014) · CUNY Academic Works (City University of New York)

The characterisation of telomere dynamics in Myelodysplastic syndromes

Williams, J. (2014) · ORCA Online Research @Cardiff (Cardiff University)

Telomere-Related Factors and Human Papillomavirus Genome Maintenance

Rogers, A. J. (2013) · Lincoln (University of Nebraska)

New players in end-protection: LIM-domain proteins associate with the shelterin complex

Denchi, E. L. (2010) · Aging · doi:10.18632/aging.100177

Structure and Functions of Telomeres in Organismal Homeostasis and Disease

Kroustallaki, P., & Gagos, S. (2015) · Springer eBooks · doi:10.1007/978-1-4939-3070-8_10

Regulation of Telomere Maintenance by the Shelterin Complex in Fission Yeast Schizosaccharomyces pombe

Chang, Y.-T. (2014) · Figshare

Characterizing the functions of Trypanosoma brucei TIF2 and TRF in regulation of antigenic variation

Jehi, S. E. (2014) · OhioLink ETD Center (Ohio Library and Information Network)

New Insights into the Regulation of Hematopoietic Stem Cell Self-Renewal.

Jones, M. (2015) · Deep Blue (University of Michigan)

Neoplasia of the Gastrointestinal Tract

Margalit, O., & DuBois, R. N. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch31

Biogenesis and Redox Transition of Iron-sulfur Clusters in Proteins

Landry, A. P. (2015) · Louisiana State University · doi:10.31390/gradschool_dissertations.398

Telomere architecture and maintenance in schizosaccharomyces pombe

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miRNA Regulation of Telomerase: A Novel Therapeutic Approach for Cancer

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EXPLORING GENOME INTEGRITY PATHWAYS IN SACCHAROMYCES CEREVISIAE

Shanmugan, M. K. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/shanmugam-muthukumar_phd2014-01-24

Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability

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Telomeres and telomere dysfunctions

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Eixo XPC-P53-H202 e disfunção mitocondrial: qual é o fator central?

Freire, T. D. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2018.tde-12122018-114933

Oncofetal HMGA2 as a key regulator of telomere stability through control of DNA topology

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The identification and characterization of EWS as a telomerase-associated protein

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Correlative light and electron microscopy of telomeric repeat-binding factor 1 in mammalian cells

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RECQL4; Linking DNA Replication and Bone Tumourigenesis

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