The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding
Open accessAbstract
SUMMARY Golgi membranes, from yeast to humans, are uniquely enriched in phosphatidylinositol-4-phosphate (PtdIns(4)P), although the role of this lipid remains poorly understood. Using a proteomic lipid binding screen, we identify the Golgi protein GOLPH3 (also called GPP34, GMx33, MIDAS, or yeast Vps74p) as a PtdIns(4)P-binding protein that depends upon PtdIns(4)P for its Golgi localization. We further show that GOLPH3 binds the unconventional myosin MYO18A, thus connecting the Golgi to F-actin. We demonstrate that this linkage is necessary for normal Golgi trafficking and morphology. The evidence suggests that GOLPH3 binds to PtdIns(4)P-rich trans-Golgi membranes and MYO18A conveying a tensile force required for efficient tubule and vesicle formation. Consequently, this tensile force stretches the Golgi into the extended ribbon observed by fluorescence microscopy and the familiar flattened form observed by electron microscopy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure
Peter, B. J., Kent, H. M., Mills, I. G., Vallis, Y., Butler, P. J. G., Evans, P. R., & McMahon, H. T. (2004) · Science · doi:10.1126/science.1092586 · Cited by 1,636
Molecular machinery for non-vesicular trafficking of ceramide
Hanada, K., Kumagai, K., Yasuda, S., Miura, Y., Kawano, M., Fukasawa, M., & Nishijima, M. (2003) · Nature · doi:10.1038/nature02188 · Cited by 1,051
Conserved microtubule–actin interactions in cell movement and morphogenesis
Rodriguez, O. C., Schaefer, A. W., Mandato, C. A., Forscher, P., Bement, W. M., & Waterman-Storer, C. M. (2003) · Nature Cell Biology · doi:10.1038/ncb0703-599 · Cited by 844
Berg, J. S., Powell, B. C., & Cheney, R. E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.4.780 · Cited by 770
Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi
Wang, Y. J., Wang, J., Sun, H. Q., Martinez, M., Sun, Y. X., Macia, E., Kirchhausen, T., Albanesi, J. P., Roth, M. G., & Yin, H. L. (2003) · Cell · doi:10.1016/s0092-8674(03)00603-2 · Cited by 552
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P
Godi, A., Campli, A. D., Konstantakopoulos, A., Tullio, G. D., Alessi, D. R., Kular, G. S., Daniele, T., Marra, P., Lucocq, J. M., & Matteis, M. A. D. (2004) · Nature Cell Biology · doi:10.1038/ncb1119 · Cited by 540
Godi, A., Pertile, P., Meyers, R., Marra, P., Di Tullio, G., Iurisci, C., Luini, A., Corda, D., & De Matteis, M. A. (1999) · Nature Cell Biology · doi:10.1038/12993 · Cited by 539
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., & Hafen, E. (2003) · Nature Cell Biology · doi:10.1038/ncb995 · Cited by 530
DOWLER, S., Currie, R. A., CAMPBELL, D. G., Deák, M., Kular, G. S., Downes, C. P., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510019 · Cited by 517
Levine, T. P., & Munro, S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00779-0 · Cited by 493
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
Hammond, G. R. V., Machner, M. P., & Balla, T. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201312072 · Cited by 453
Germline mutations in TMEM127 confer susceptibility to pheochromocytoma
Qin, Y., Yao, L., King, E. E., Buddavarapu, K., Lenci, R. E., Chocron, E. S., Lechleiter, J. D., Sass, M., Aronin, N., Schiavi, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.533 · Cited by 379
Harbour, M. E., Breusegem, S. Y. A., Antrobus, R., Freeman, C., Reid, E., & Seaman, M. N. J. (2010) · Journal of Cell Science · doi:10.1242/jcs.071472 · Cited by 246
Rizzo, R., Russo, D., Kurokawa, K., Sahu, P., Lombardi, B., Supino, D., Zhukovsky, M. A., Vocat, A., Pothukuchi, P., Kunnathully, V., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020107238 · Cited by 101
Metadata
- Authors
- Dippold, H. C., Ng, M. M., Farber-Katz, S. E., Lee, S.-K., Kerr, M. L., Peterman, M. C., Sim, R., Wiharto, P. A., Galbraith, K. A., Madhavarapu, S., Fuchs, G. J., Meerloo, T., Farquhar, M. G., Zhou, H., & Field, S. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 139
- Issue
- 2
- Pages
- 337-351
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2152269520
- Cited by
- 448
- References
- 56
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding. https://app.cochat.ai/papers/10.1016/j.cell.2009.07.052
- The paper
- Dippold, H. C., Ng, M. M., Farber-Katz, S. E., Lee, S.-K., Kerr, M. L., Peterman, M. C., Sim, R., Wiharto, P. A., Galbraith, K. A., Madhavarapu, S., Fuchs, G. J., Meerloo, T., Farquhar, M. G., Zhou, H., & Field, S. J. (2009). GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding. Cell. https://doi.org/10.1016/j.cell.2009.07.052
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
