Conserved microtubule–actin interactions in cell movement and morphogenesis
Abstract
Interactions between microtubules and actin are a basic phenomenon that underlies many fundamental processes in which dynamic cellular asymmetries need to be established and maintained. These are processes as diverse as cell motility, neuronal pathfinding, cellular wound healing, cell division and cortical flow. Microtubules and actin exhibit two mechanistic classes of interactions--regulatory and structural. These interactions comprise at least three conserved 'mechanochemical activity modules' that perform similar roles in these diverse cell functions.
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The interaction between actin filaments and microtubules is important for cellular processes including cell division, vesicle and organelle transport, axonal growth and migration.
“The interaction between actin filaments and microtubules is important for cellular processes including cell division, vesicle and organelle transport, axonal growth and migration66.”
From Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau (2017) · cites this paper as [66]
Overall, these data support a role for tau as a regulator of microtubules and actin, and suggest that tau is a potential linker between the two cytoskeletons.
“Overall, these data support a role for tau as a regulator of microtubules and actin, and suggest that tau is a potential linker between the two cytoskeletons as hypothesized some years ago1.”
From Tau co-organizes dynamic microtubule and actin networks (2015) · cites this paper as [1]
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Biological wires, communication systems, and implications for disease
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- Authors
- Rodriguez, O. C., Schaefer, A. W., Mandato, C. A., Forscher, P., Bement, W. M., & Waterman-Storer, C. M.
- Affiliations
- Scripps Research Institute (US)
- Yale University (US)
- McGill University (CA)
- University of Wisconsin–Madison (US)
- Venue
- Nature Cell Biology
- Published
- 2003-07
- Volume
- 5
- Issue
- 7
- Pages
- 599-609
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2032100189
- Cited by
- 844
- References
- 1
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 8 · 2023: 11 · 2022: 15 · 2021: 22 · 2020: 30 · 2019: 26 · 2018: 28 · 2017: 42 · 2016: 31 · 2015: 42 · 2014: 49 · 2013: 55 · 2012: 51
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-61804-03, R01GM052932, GM52932-04A1, R01GM061804)
- National Institute of Neurological Disorders and Stroke (R01NS028695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- actin-microtubule interaction, cell motility, cell morphogenesis, neuronal pathfinding, wound healing, cell division, cortical flow
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Cell Movement, Contractile Proteins, Eukaryotic Cells, Humans, Actin Cytoskeleton, Microtubules, Wound Healing, Growth Cones
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