Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David M.·2010·Cell

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    Clare Stretton, Thorsten M. Hoffmann, Michael J. Munson, A. Prescott, P. M. Taylor, I. Ganley, H. Hundal · 2015 · Biochemical Journal
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  4. Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
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  8. Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation inSaccharomyces cerevisiae
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  9. Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9
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  10. Expression of mTOR in normal and pathological conditions
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  11. Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease
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  12. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice
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  13. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
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  14. Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis
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  15. An intestinal zinc sensor regulates food intake and developmental growth
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  16. The Inositol Phosphate System—A Coordinator of Metabolic Adaptability
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  17. The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency.
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  18. Microtubule-associated Protein/Microtubule Affinity-regulating Kinase 4 (MARK4) Is a Negative Regulator of the Mammalian Target of Rapamycin Complex 1 (mTORC1)
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  19. The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity
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  20. MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation
    Fawal, Mohamad-Ali, Brandt, Marta, Djouder, Nabil · 2015 · Developmental Cell
  21. The role of innate immunity in mucopolysaccharide diseases
    Helen Parker, Brian Bigger · 2018 · Journal of Neurochemistry
  22. Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling
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  23. Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
    Qiuli Liang, Xiaosen Ouyang, Lonnie E. Schneider, Jianhua Zhang · 2011 · Molecular Neurodegeneration
  24. The immunosuppressive enzyme IL4I1 promotes FoxP3 + regulatory T lymphocyte differentiation
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  25. mTOR Signalling in Head and Neck Cancer: Heads Up
    Fiona H. Tan, Yuchen Bai, P. Saintigny, C. Darido · 2019 · Cells
  26. Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment
    B. Angarola, S. Ferguson · 2019 · bioRxiv
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    Stephanie M. Salabarria, Jayakrishnan Nair, N. Clement, Barbara K. Smith, Nina Raben, David Dwight Fuller, Barry J. Byrne, Manuela Corti · 2019 · Journal of Neuromuscular Diseases
  28. Lysosome signaling in cell survival and programmed cell death for cellular homeostasis
    S. Patra, S. Patil, D. Klionsky, S. Bhutia · 2022 · Journal of Cellular Physiology
  29. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
    Jianling Xie, Godwin A. Ponuwei, Claire E. Moore, Gary B. Willars, Andrew R. Tee, Terence P. Herbert · 2011 · Cellular Signalling
  30. mTOR signaling in autophagy regulation in the kidney
    K. Inoki · 2013 · Seminars in Nephrology
  31. Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer
    Claudio Daniel González, Silvia Álvarez, Alejandro Ropolo, Carla Rosenzvit, María Florencia González Bagnes, María I. Vaccaro · 2014 · BioMed Research International
  32. mTOR Kinase: A Possible Pharmacological Target in the Management of Chronic Pain
    Lucia Lisi, Paola Aceto, Pierluigi Navarra, Cinzia Dello Russo · 2015 · BioMed Research International
  33. The vacuole/lysosome is required for cell-cycle progression
    Yui Jin, Lois S. Weisman · 2015 · eLife
  34. Leucine and Mammalian Target of Rapamycin–Dependent Activation of Muscle Protein Synthesis in Aging
    Jean Pascal De Bandt · 2016 · Journal of Nutrition
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    Giorgia Zadra, Massimo F. Loda · 2017 · Cold Spring Harbor Perspectives in Medicine
  36. Crystal Structure of the Gtr1pGTP-Gtr2pGDP Protein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion
    Jeong, Jae-Hee, Lee, Kwang-Hoon, Kim, Young-Mi, Kim, Do-Hyung, Oh, Byung-Ha, Kim, Yeon-Gil · 2012 · Journal of Biological Chemistry
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    Mirai Tanigawa, Tatsuya Maeda · 2017 · Molecular and Cellular Biology
  38. mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target
    Aleksandra Babicheva, Ayako Makino, Jason X.‐J. Yuan · 2021 · International Journal of Molecular Sciences
  39. Spatial and functional separation of mTORC1 signalling in response to different amino acid sources
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    Kruse, Rikke, Vind, Birgitte F., Petersson, Stine J., Kristensen, Jonas M., Højlund, Kurt · 2015 · Diabetologia
  46. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress
    Chau, Gia Cac, Im, Dong Uk, Kang, Tong Mook, Bae, Jeong Mo, Kim, Won, Pyo, Suhkneung, Moon, Eun-Yi, Um, Sung Hee · 2017 · Journal of Cell Biology
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  48. Beyond Indigestion: Emerging Roles for Lysosome-Based Signaling in Human Disease
    S. Ferguson · 2015 · Current Opinion in Cell Biology
  49. SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity
    Venkatraman Ravi, Aditi Jain, Danish Khan, Faiz Ahamed, Sneha Mishra, Malyasree Giri, Meena Inbaraj, Swati Krishna, Mohsen Sarikhani, Sangeeta Maity et al. · 2019 · Nucleic Acids Research
  50. Therapeutic Approaches in Lysosomal Storage Diseases
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  51. Evolutionarily divergent mTOR remodels translatome for tissue regeneration
    Olena Zhulyn, Hannah D. Rosenblatt, Leila Shokat, Shizhong A. Dai, Duygu Kuzuoğlu‐Öztürk, Zijian Zhang, Davide Ruggero, Kevan M. Shokat, Maria Barna · 2023 · Nature
  52. The metabolic sensor AMPK: Twelve enzymes in one
    William J. Smiles, Ashley J. Ovens, Jonathan S. Oakhill, Barbara Kofler · 2024 · Molecular Metabolism
  53. The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes
    Jianling Xie, Terence P. Herbert · 2011 · Cellular and Molecular Life Sciences
  54. V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis
    Eva Maria Gleixner, Guillaume Canaud, Tobias F. Hermle, María Clara Guida, Oliver Kretz, Martin Helmstädter, Tobias Bruno Huber, Stefan Eimer, Fabiola Terzi, Matias Simons · 2014 · Cell Reports
  55. Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells
    Keng-Poo Tan, Ming‐Yi Ho, Huan-Chieh Cho, John Yu, Jung‐Tung Hung, Alice Lin-Tsing Yu · 2016 · Cell Death and Disease
  56. The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways
    Mengnan Xu, Shekoufeh Almasi, Yi Yang, Chi Wing Yan, Andra Mihaela Sterea, Alia Kazim Rizvi Syeda, Bing Q. Shen, Derek R. Clements, Peng Huang, Shashi Ashok Gujar et al. · 2019 · Cell Calcium
  57. Crosstalk of Hedgehog and mTORC1 Pathways
    Lasse Jonsgaard Larsen, Lisbeth Birk Møller · 2020 · Cells
  58. Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming
    Srikanth Battu, Gillipsie Minhas, Aman Mishra, Nooruddin Khan · 2017 · Frontiers in Immunology
  59. Lysosome positioning coordinates mTORC1 activity and autophagy
    Christian Poüs, Patrice Codogno · 2011 · Nature Cell Biology
  60. Regulation and Function of Uncoordinated-51 Like Kinase Proteins
    Edmond Y.W. Chan · 2011 · Antioxidants and Redox Signaling
  61. Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction
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  62. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
    S-J Fan, Cameron Edward Snell, Helen Turley, JL Li, Regan D. McCormick, Sumeth Perera, Sabine Heublein, Shubana Kazi, Abul Kalam Azad, CLIVE G. WILSON et al. · 2015 · Oncogene
  63. A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals
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  64. Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.
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  65. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
    Stefanie Ruf, Alexander Martin Heberle, Miriam Langelaar‐Makkinje, Sara Gelino, Deepti Wilkinson, Carolin Gerbeth, Jennifer Schwarz, Birgit Holzwarth, Bettina Warscheid, Chris Meisinger et al. · 2017 · Autophagy
  66. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
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  67. Maintenance of CD4 T cell fitness through regulation of Foxo1
    Ryan H. Newton, Sharad Shrestha, Jenna M. Sullivan, Kathleen B. Yates, Ewoud Bernardus Compeer, Noga Ron‐Harel, Bruce R. Blazar, Steven J. Bensinger, W. Nicholas Haining, Michael Loran Dustin et al. · 2018 · Nature Immunology
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  69. Metabolic regulation of organelle homeostasis in lupus T cells
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  71. Autophagy: a targetable linchpin of cancer cell metabolism
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  74. Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
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  75. Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: Novel considerations
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  76. Cardiomyocyte health: adapting to metabolic changes through autophagy
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  79. Rab5 Proteins Regulate Activation and Localization of Target of Rapamycin Complex 1
    Dave Bridges, Kaleigh Fisher, Sergey N. Zolov, Tingting Xiong, Ken Inoki, Lois S. Weisman, Alan R. Saltiel · 2012 · Journal of Biological Chemistry
  80. Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1
    Tianlong Zhang, Marie‐Pierre Gulli, Hui Yang, Claudio DE VIRGILIO, Jianping Ding · 2012 · Structure
  81. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes
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  82. Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells
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  83. Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
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  86. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
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  87. Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances
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  88. Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
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  90. Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia
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  91. A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers
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  92. The physiological regulation of macropinocytosis during Dictyostelium growth and development
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  93. The Vam6-Gtr1/Gtr2 pathway activates TORC1 in response to amino acids in fission yeast
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  99. mTOR in health and in sickness
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