Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David M.·2010·Cell

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  1. Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth
    Inbar Azoulay‐Alfaguter, R Elya, Limor Avrahami, A Katz, Hagit Eldar-Finkelman · 2014 · Oncogene
  2. Autophagy and cell growth – the yin and yang of nutrient responses
    Thomas P. Neufeld · 2012 · Journal of Cell Science
  3. Macropinocytosis, mTORC1 and cellular growth control
    Yoshida, Sei, Pacitto, Regina, Inoki, Ken, Swanson, Joel · 2018 · Cellular and Molecular Life Sciences
  4. An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
    Richard Odle, Simon A. Walker, David Oxley, Andrew M. Kidger, Kathryn Balmanno, Rebecca Gilley, Hanneke Okkenhaug, Oliver Florey, Nicholas T. Ktistakis, Simon J. Cook · 2019 · Molecular Cell
  5. Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo
    Isabel Martín González, Patrick M. Martin, Carol A. Burdsal, Jennifer L. Sloan, Sela Mager, Thurl E. Harris, Ann E. Sutherland · 2011 · Developmental Biology
  6. Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans
    Soudabeh Imanikia, Neşem P. Özbey, Christel Krueger, Olivia Casanueva, Rebecca C. Taylor · 2019 · Current Biology
  7. The Lysosome at the Intersection of Cellular Growth and Destruction
    Hijai R. Shin, Roberto Zoncu · 2020 · Developmental Cell
  8. Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis
    Mark von Zastrow, Alexander D. Sorkin · 2021 · Annual Review of Biochemistry
  9. Amino acid management in cancer
    Zhi-Yang Tsun, Richard Possemato · 2015 · Seminars in Cell and Developmental Biology
  10. Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die
    Jee-Yeon Hwang, Michael J. Gertner, Fabrizio Pontarelli, Brenda L. Court-Vazquez, Michael V. L. Bennett, Dimitry Ofengeim, Ruth Suzanne Zukin · 2016 · Cell Death and Differentiation
  11. Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
    Ronnie Blazev, Christian Strini Carl, Yaan‐Kit Ng, Jeffrey Molendijk, Christian T. Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J. Kueh, Paula Michelle Miotto, Vanessa R. Haynes et al. · 2022 · Cell Metabolism
  12. Right Time, Right Place: Probing the Functions of Organelle Positioning
    Petra van Bergeijk, Casper C. Hoogenraad, Lukas C. Kapitein · 2015 · Trends in Cell Biology
  13. The role of membrane-trafficking small GTPases in the regulation of autophagy
    Carla F. Bento, Claudia Puri, Kévin Moreau, David Chaim Rubinsztein · 2013 · Journal of Cell Science
  14. A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
    Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S.H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm et al. · 2022 · Nature Metabolism
  15. The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
    Elizabeth R. Gallagher, Erika L.F. Holzbaur · 2023 · Cell Reports
  16. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3
    Villegas, Florian, Lehalle, Daphné, Mayer, Daniela, Rittirsch, Melanie, Stadler, Michael B., Zinner, Marietta, Olivieri, Daniel, Vabres, Pierre, Duplomb-Jego, Laurence, De Bont, Eveline S.J.M. et al. · 2019 · Cell Stem Cell
  17. Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
    James E Hughes Hallett, Xiangxia Luo, Andrew P. Capaldi · 2015 · eLife
  18. Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals
    Valerie P. Tan, Shigeki Miyamoto · 2016 · Journal of Molecular and Cellular Cardiology
  19. Starved epithelial cells uptake extracellular matrix for survival
    Taru E. Muranen, Marcin Iwanicki, Natasha L. Curry, Julie Hwang, Cory D. DuBois, Jonathan L. Coloff, Daniel S. Hitchcock, Clary B. Clish, Joan S. Brugge, Nada Y. Kalaany · 2017 · Nature Communications
  20. The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy
    Celine Deneubourg, Mauricio Ramm, Luke J. Smith, Olga Baron, Kritarth Singh, Susan Byrne, Michael R. Duchen, Mathias Gautel, Eeva‐Liisa Eskelinen, Manolis Fanto et al. · 2021 · Autophagy
  21. Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy
    Kunpeng Liu, Dongbo Qiu, Xue Liang, Yingqi Huang, Yao Wang, Xin Jia, Kun Li, Jingyuan Zhao, Cong Du, Xiusheng Qiu et al. · 2021 · Autophagy
  22. Pompe Disease: New Developments in an Old Lysosomal Storage Disorder
    Naresh Kumar Meena, Nina Raben · 2020 · Biomolecules
  23. The Molecular Basis for Load-Induced Skeletal Muscle Hypertrophy
    George R. Marcotte, Daniel W. D. West, Keith Baar · 2014 · Calcified Tissue International
  24. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
    Boxiao Ding, Anita Parmigiani, Ajit S. Divakaruni, Kellie J. Archer, Anne N. Murphy, Andrei V. Budanov · 2016 · Scientific Reports
  25. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
    Jenna L. Jewell, Vivian X. Fu, Audrey W. Hong, Fa‐Xing Yu, Delong Meng, Chase H. Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan Serota Taylor et al. · 2019 · eLife
  26. mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management
    Silvia Cetrullo, Stefania D’Adamo, Benedetta Tantini, Rosa Maria Borzı̀, Flavio Flamigni · 2015 · Critical Reviews in Eukaryotic Gene Expression
  27. Ras moves to stay in place
    Malte Schmick, Astrid Kraemer, Philippe I. H. Bastiaens · 2015 · Trends in Cell Biology
  28. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb
    Andrew Ryan Kelleher, Scot R. Kimball, Michael Don Dennis, Rudolf Johannes Schilder, Leonard S. Jefferson · 2012 · American Journal of Physiology-Endocrinology and Metabolism
  29. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
    Kuo‐Hui Su, Junyue Cao, Zijian Tang, Siyuan Dai, Yishu He, Stephen B. Sampson, Ivor J. Benjamin, Chengkai Dai · 2016 · Nature Cell Biology
  30. The Metabolic Landscape of Prostate Cancer
    Francesca Giunchi, Michelangelo Fiorentino, Massimo F. Loda · 2018 · European Urology Oncology
  31. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
    Nicola Alesi, Elie W. Akl, Damir Khabibullin, Heng-Jia Liu, Anna S. Nidhiry, Emma R. Garner, Harilaos Filippakis, Hilaire Colletta Lam, Wei Shi, Srinivas Raghavan Viswanathan et al. · 2021 · Nature Communications
  32. The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses
    Danrui Cui, Ruirui Qu, Dian Liu, Xiufang Xiong, Tingbo Liang, Yongchao Zhao · 2021 · Frontiers in Cell and Developmental Biology
  33. Autophagic lysosome reformation in health and disease
    Randini Nanayakkara, Rajendra Gurung, Samuel J. Rodgers, Matthew J. Eramo, Georg Ramm, Christina Anne Mitchell, Meagan J. McGrath · 2022 · Autophagy
  34. Regulation of TOR by small GTPases
    Durán, Raúl V, Hall, Michael N · 2012 · The EMBO Reports
  35. TSC1/TSC2 signaling in the CNS
    Han, Juliette M., Sahin, Mustafa · 2011 · FEBS Letters
  36. The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase
    Shunsuke Mori, Shigeyuki Nada, Hironobu Kimura, Shoji Tajima, Yusuke Takahashi, Ayaka Kitamura, Chitose Oneyama, Masato Okada · 2014 · PLoS ONE
  37. Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)
    Limei Xu, Darin Salloum, Phil S. Medlin, Mahesh Saqcena, Paige Yellen, Benjamin Perrella, David A. Foster · 2011 · Journal of Biological Chemistry
  38. MiT/TFE factors control ER‐phagy via transcriptional regulation of FAM134B
    Laura Cinque, Chiara De Leonibus, Maria Iavazzo, Natalie Krahmer, Daniela Intartaglia, Francesco Giuseppe Salierno, Rossella De Cegli, Chiara Di Malta, Maria Svelto, Carmela Lanzara et al. · 2020 · The EMBO Journal
  39. Cellular and molecular effects of the mTOR inhibitor everolimus
    Uttara Saran, Michelangelo Foti, Jean‐François Dufour · 2015 · Clinical Science
  40. Expanding the View of IKK: New Substrates and New Biology
    Ricardo J. Antonia, Robert S. Hagan, Albert S. Baldwin · 2021 · Trends in Cell Biology
  41. mTOR and the health benefits of exercise.
    Kurt Watson, K. Baar · 2014 · Seminars in Cell and Developmental Biology
  42. Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway
    Yamada, Eijiro, Bastie, Claire C., Koga, Hiroshi, Wang, Yichen, Cuervo, Ana Maria, Pessin, Jeffrey E. · 2012 · Cell Reports
  43. Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1
    Liufeng Zheng, Wei Zhang, Yuanfei Zhou, Fengna Li, Hongkui Wei, Jian Peng · 2016 · International Journal of Molecular Sciences
  44. Regulation of Cancer Metabolism by Oncogenes and Tumor Suppressors
    Raffaella Iurlaro, Clara Lucía León‐Annicchiarico, Cristina Muñoz‐Pinedo · 2014 · Methods in enzymology on CD-ROM/Methods in enzymology
  45. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
    Shen, Kuang, Choe, Abigail, Sabatini, David M. · 2017 · Molecular Cell
  46. Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy
    Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya · 2017 · Current Diabetes Reports
  47. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold
    R. Lawrence, K. Cho, Ronja Rappold, Anna Thrun, Marie Tofaute, Do Jin Kim, Ofer Moldavski, J. Hurley, R. Zoncu · 2018 · Nature Cell Biology
  48. Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit
    Nathan Meade, Colleen Furey, Hua Li, Rita Verma, Qingqing Chai, Madeline G. Rollins, Stephen DiGiuseppe, Mojgan H. Naghavi, Derek Walsh · 2018 · Cell
  49. Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
    Xiaoli Zhang, Wei Chen, Qiong Gao, Junsheng Yang, Xueni Yan, Han Zhao, Lin Su, Meimei Yang, Chenlang Gao, Yao Yao et al. · 2019 · PLoS Biology
  50. Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster
    Manuela Piazzi, Alberto Bavelloni, Angela Gallo, Irene Faenza, William L. Blalock · 2019 · International Journal of Molecular Sciences
  51. New developments in AMPK and mTORC1 cross-talk
    William J. Smiles, Ashley J. Ovens, Bruce E. Kemp, Sandra Galić, Janni Petersen, Jonathan S. Oakhill · 2024 · Essays in Biochemistry
  52. Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid
    Mee‐Sup Yoon, Christina L. Rosenberger, Cong Wu, Nga Truong, Jonathan V. Sweedler, Jie Chen · 2015 · Molecular Cell
  53. Autophagy modulates cell migration and β1 integrin membrane recycling
    Véronique Tuloup-Minguez, Ahmed Hamaï, Anne Greffard, Valérie Nicolas, Patrice Codogno, Joëlle Botti · 2013 · Cell Cycle
  54. Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs
    Kush K. Patel, Khosrow Kashfi · 2021 · Biochemical Pharmacology
  55. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
    Huanhu Zhu, Huali Shen, Aileen K. Sewell, Marina Kniazeva, Min Han · 2013 · eLife
  56. Rheb and Rags come together at the lysosome to activate mTORC1
    Groenewoud, Marlous J., Zwartkruis, Fried J.T. · 2013 · Biochemical Society Transactions
  57. Targeting mTOR network in colorectal cancer therapy
    Xiaowen Wang · 2014 · World Journal of Gastroenterology
  58. Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling
    Shushi Nagamori, Pattama Wiriyasermkul, Suguru Okuda, Naoto Kojima, Yoshiyuki Hari, Shigeki Kiyonaka, Yasuo Mori, Hideyuki Tominaga, Ryuichi Ohgaki, Yoshikatsu Kanai · 2016 · Amino Acids
  59. Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling
    Zuzanna Andrzejewska, Nathalie Névo, Lucie Thomas, Cérina Chhuon, A Bailleux, Véronique Chauvet, Pierre J. Courtoy, Marie Chol, Ida Chiara Guerrera, Corinne Antignac · 2015 · Journal of the American Society of Nephrology
  60. Transcriptional regulation of the stress response by mTOR
    Jose F. Aramburu, M. Carmen Ortells, Sonia Tejedor Vaquero, Maria Buxadé, Cristina López‐Rodríguez · 2014 · Science Signaling
  61. Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
    Gong, Rui, Li, Li, Liu, Yi, Wang, Ping, Yang, Huirong, Wang, Ling, Cheng, Jingdong, Guan, Kun-Liang, Xu, Yanhui · 2011 · Genes & Development
  62. Regulation of mTORC1 by Upstream Stimuli
    Chase H. Melick, Jenna L. Jewell · 2020 · Genes
  63. Structural analysis of the Ras‐like G protein MglA and its cognate GAP MglB and implications for bacterial polarity
    Mandy Miertzschke, Carolin Koerner, Ingrid R. Vetter, Daniela Keilberg, Edina Hot, Simone Leonardy, Lotte Søgaard‐Andersen, Alfred Wittinghofer · 2011 · The EMBO Journal
  64. Autophagy-regulating small molecules and their therapeutic applications
    Kyung-Hwa Baek, Jihye Park, Injae Shin · 2012 · Chemical Society Reviews
  65. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy
    Rosa Bartolomeo, Laura Cinque, Chiara De Leonibus, Alison R. Forrester, Anna Chiara Salzano, Jlenia Monfregola, Emanuela De Gennaro, Edoardo Nusco, Isabella Azario, Carmela Lanzara et al. · 2017 · Journal of Clinical Investigation
  66. Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply
    Hao Zhang, Shengmin Yan, Bilon Khambu, Fengguang Ma, Yong Li, Xiaoyun Chen, José A. Martina, Rosa Puertollano, Yu Li, Naga Chalasani et al. · 2018 · Autophagy
  67. Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
    Josué M. J. Ramírez-Reyes, R. Cuesta, A. Pause · 2021 · Frontiers in Cell and Developmental Biology
  68. Rag GTPases are cardioprotective by regulating lysosomal function
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  69. Tracing the Archaeal Origins of Eukaryotic Membrane-Trafficking System Building Blocks.
    C. M. Klinger, A. Spang, J. Dacks, T. Ettema · 2016 · Molecular biology and evolution
  70. Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice
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  71. TOR and ageing: a complex pathway for a complex process
    Mark A. McCormick, Shih‐Yin Tsai, Brian Keith Kennedy · 2010 · Philosophical Transactions of the Royal Society B Biological Sciences
  72. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
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  75. Regulation of CD8+ T memory and exhaustion by the mTOR signals
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  77. Regulation of rDNA transcription in response to growth factors, nutrients and energy
    Eric P. Kusnadi, Katherine M. Hannan, Rodney J. Hicks, Ross D. Hannan, Richard B. Pearson, Jian Kang · 2014 · Gene
  78. The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
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  79. Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth
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  80. Roles for PI(3,5)P2 in nutrient sensing through TORC1
    Natsuko Jin, Kai Mao, Yui Jin, Gela G. Tevzadze, Emily J. Kauffman, Sujin Park, Dave Bridges, Robbie Loewith, Alan R. Saltiel, Daniel J. Klionsky et al. · 2014 · Molecular Biology of the Cell
  81. Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer.
    Ju-Deng Zeng, W. Wu, Hui-Yun Wang, Xiao-Xing Li · 2019 · Pharmacological Research
  82. Accelerated Kidney Aging in Diabetes Mellitus
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  84. Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis
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  85. mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
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  86. Androgen-mediated regulation of skeletal muscle protein balance
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  87. Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II
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  88. Modulation of mTOR signaling as a strategy for the treatment of Pompe disease
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  89. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
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  90. Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling
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  91. AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells
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  92. Mechanisms Involved in the Coordinate Regulation of mTORC1 by Insulin and Amino Acids
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  93. TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux
    Bo Pan, Hanming Zhang, Taixing Cui, Xuejun Wang · 2017 · Journal of Molecular and Cellular Cardiology
  94. Emerging roles and regulation of MiT/TFE transcriptional factors
    Min Yang, En Liu, Li Tang, Yuanyuan Lei, Xuemei Sun, Jiaxi Hu, Hui Dong, Shiming Yang, Mingfa Gao, Bo Tang · 2018 · Cell Communication and Signaling
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  96. SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling
    Kim, Young-Mi, Stone, Matthew, Hwang, Tae Hyun, Kim, Yeon-Gil, Dunlevy, Jane R., Griffin, Timothy J., Kim, Do-Hyung · 2012 · Molecular Cell
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    Xiliang Du, Chiara Di Malta, Zhiyuan Fang, Taiyu Shen, Xiaodi Niu, Meng Chen, Bo Jin, Hao Yu, Lin Lei, Wenwen Gao et al. · 2021 · Acta Pharmaceutica Sinica B
  100. The m TOR pathway and integrating immune regulation
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