Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David M.·2010·Cell
DOI 10.1016/j.cell.2010.02.024

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  2. Human Cytomegalovirus: Coordinating Cellular Stress, Signaling, and Metabolic Pathways
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  3. Regulation of mTORC1 Complex Assembly and Signaling by GRp58/ERp57
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  15. Mammalian target of rapamycin and the kidney. I. The signaling pathway
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  16. Rag GTPase in amino acid signaling
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  20. Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals
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  21. Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
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  22. mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    Dave Bridges, Alan R. Saltiel · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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  53. Human Cytomegalovirus Infection Maintains mTOR Activity and Its Perinuclear Localization during Amino Acid Deprivation
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  54. NR4A nuclear receptors in cardiac remodeling and neurohormonal regulation
    Lejla Medzikovic, Carlie J.M. de Vries, Vivian de Waard · 2018 · Trends in Cardiovascular Medicine
  55. Nutrient Sensing in Cancer
    Margaret E. Torrence, Brendan D. Manning · 2017 · Annual Review of Cancer Biology
  56. Regulation of mTORC1 by Small GTPases in Response to Nutrients.
    Min Zhu, Xiu-Qi Wang · 2020 · Journal of NutriLife
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  63. The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
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  98. TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules
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