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Cited by 354RNA and protein synthesis mechanismsRNA modifications and cancerEvolution and Genetic Dynamics

A Role for Codon Order in Translation Dynamics

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Cannarozzi, Gina, Schraudolph, Nicol N., Faty, Mahamadou, von Rohr, Peter, Friberg, Markus T., Roth, Alexander C., Gonnet, Pedro, Gonnet, Gaston +1 more·2010·Cell
DOI 10.1016/j.cell.2010.02.036
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Abstract

The genetic code is degenerate. Each amino acid is encoded by up to six synonymous codons; the choice between these codons influences gene expression. Here, we show that in coding sequences, once a particular codon has been used, subsequent occurrences of the same amino acid do not use codons randomly, but favor codons that use the same tRNA. The effect is pronounced in rapidly induced genes, involves both frequent and rare codons and diminishes only slowly as a function of the distance between subsequent synonymous codons. Furthermore, we found that in S. cerevisiae codon correlation accelerates translation relative to the translation of synonymous yet anticorrelated sequences. The data suggest that tRNA diffusion away from the ribosome is slower than translation, and that some tRNA channeling takes place at the ribosome. They also establish that the dynamics of translation leave a significant signature at the level of the genome.

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Cited by

Sorted by citations

Authors
Cannarozzi, G., Schraudolph, N. N., Faty, M., von Rohr, P., Friberg, M. T., Roth, A. C., Gonnet, P., Gonnet, G., & Barral, Y.
Affiliations
  • SIB Swiss Institute of Bioinformatics (CH)
  • ETH Zurich (CH)
Corresponding author
Barral, Yves
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2010-04
Volume
141
Issue
2
Pages
355-367
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2010.02.036
OpenAlex
W2148627082
Cited by
354
References
2
Citations by year
2026: 4 · 2025: 17 · 2024: 19 · 2023: 18 · 2022: 16 · 2021: 25 · 2020: 20 · 2019: 19 · 2018: 14 · 2017: 24 · 2016: 17 · 2015: 20 · 2014: 46 · 2013: 29 · 2012: 40
FWCI
11.41
Type
journal article
Language
en
Update notices
erratum (2010-05-14)
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Francis Crick Institute
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Eidgenössische Technische Hochschule Zürich
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
synonymous codons, genetic code degeneracy, translation dynamics, rare codons, Saccharomyces cerevisiae, gene expression
MeSH terms
Amino Acids, Codon, Ribosomes, RNA, Messenger, RNA, Transfer, Saccharomyces cerevisiae, Protein Biosynthesis

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