Optimizing assembly and production of native bispecific antibodies by codon de-optimization

Codon bias and heterologous protein expression

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Selection on Codon Bias

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An evolutionarily conserved mechanism for controlling the efficiency of protein translation

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Codon catalog usage and the genome hypothesis

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OPTIMIZER: a web server for optimizing the codon usage of DNA sequences

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Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

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Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

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Advances in recombinant antibody manufacturing

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Recombinant protein expression for therapeutic applications

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A Role for Codon Order in Translation Dynamics

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A critical analysis of codon optimization in human therapeutics

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An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

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On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells

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Recent advances in mammalian protein production

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Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

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Therapeutic antibody expression technology

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A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons.

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BiP and Immunoglobulin Light Chain Cooperate to Control the Folding of Heavy Chain and Ensure the Fidelity of Immunoglobulin Assembly

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Advances in recombinant protein expression for use in pharmaceutical research

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Expanding Anfinsen’s Principle: Contributions of Synonymous Codon Selection to Rational Protein Design

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How the Sequence of a Gene Can Tune Its Translation

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Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells

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Codon Optimization OnLine (COOL): a web-based multi-objective optimization platform for synthetic gene design

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Unassembled Ig Heavy Chains Do Not Cycle from BiP In Vivo but Require Light Chains to Trigger Their Release

Vanhove, M., Usherwood, Y.-K., & Hendershot, L. M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00163-7 · Cited by 120 · see citing works

Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

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Computational Tools and Algorithms for Designing Customized Synthetic Genes

Gould, N., Hendy, O., & Papamichail, D. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00041 · Cited by 97 · see citing works

Computational codon optimization of synthetic gene for protein expression

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EuGene: maximizing synthetic gene design for heterologous expression

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A Small Segment of the MATα1 Transcript Promotes mRNA Decay in Saccharomyces cerevisiae : a Stimulatory Role for Rare Codons

Caponigro, G., Muhlrad, D., & Parker, R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5141-5148.1993 · Cited by 64 · see citing works

Genetic Code-guided Protein Synthesis and Folding in Escherichia coli

Hu, S., Wang, M., Cai, G., & He, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467977 · Cited by 54 · see citing works

Codon optimization of genes for efficient protein expression in mammalian cells by selection of only preferred human codons

Inouye, S., Sahara‐Miura, Y., Sato, J., & Suzuki, T. (2015) · Protein Expression and Purification · doi:10.1016/j.pep.2015.02.002 · Cited by 47 · see citing works

Biotechnology and genetic engineering in the new drug development. Part I. DNA technology and recombinant proteins

Stryjewska, A., Kiepura, K., Librowski, T., et al. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71466-x · Cited by 34 · see citing works

Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality

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High-level Expression and Purification of Active Human FGF-2 in Escherichia coli by Codon and Culture Condition Optimization

Soleyman, M. R., Khalili, M., Khansarinejad, B., & Baazm, M. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.21615 · Cited by 34 · see citing works

Codon optimization of xylA gene for recombinant glucose isomerase production in Pichia pastoris and fed-batch feeding strategies to fine-tune bioreactor performance

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Enhanced production of α-cyclodextrin glycosyltransferase in Escherichia coli by systematic codon usage optimization

Liu, H., Li, J., Du, G., Zhou, J., & Chen, J. (2012) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-012-1185-y · Cited by 25 · see citing works

Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

Ou, K.-C., Wang, C., Liu, K., Chen, Y., Chen, Y.-C., Lai, M. D., & Yen, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.10.097 · Cited by 19 · see citing works

Optimizing membrane-protein biogenesis through nonoptimal-codon usage

Morgunov, A. S., & Babu, M. M. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2926 · Cited by 13 · see citing works

Biotechnology and genetic engineering in the new drug development. Part II. Monoclonal antibodies, modern vaccines and gene therapy

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High-level expression of tamavidin 2 in human cells by codon-usage optimization

Takakura, Y., Katayama, S., & Nagata, Y. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.991690 · Cited by 7 · see citing works

GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells

Wei, W., Kim, J. M., Medina, D., Lakatta, E. G., & Li, L. (2013) · Protein Expression and Purification · doi:10.1016/j.pep.2013.12.006 · Cited by 4 · see citing works

Computational and artificial intelligence-based methods for antibody development

Kim, J., McFee, M., Fang, Q., Abdin, O., & Kim, P. M. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.12.005 · Cited by 178 · see citing works

[Expression of recombinant human ZP3 protein using the baculovirus expression system].

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Immunotherapeutic potential of bispecific antibodies

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Comparison of free κ and λ light chain immunoassays and total (bound and free) κ and λ light chain immunoassays.

Delgado, F., & Kuus, K. (2015) · PubMed · Cited by 1 · see citing works

Concentrations of Serum Free Light Chains in Kappa and Lambda Lesions in Light-Chain Myelomas

Singh, G. (2018) · Laboratory Medicine · doi:10.1093/labmed/lmy067 · Cited by 14 · see citing works

Myosin heavy chain-light chain recombinations and interactions between the two classes of light chains.

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