The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells
Open accessAbstract
Summary Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance. The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for the permanence of hearing loss and certain balance disorders. Here we present a stepwise guidance protocol starting with mouse embryonic stem (ES) and induced pluripotent stem (iPS) cells, which were directed toward becoming ectoderm capable of responding to otic-inducing growth factors. The resulting otic progenitor cells were subjected to varying differentiation conditions, one of which promoted the organization of the cells into epithelial clusters displaying hair cell-like cells with stereociliary bundles. Bundle-bearing cells in these clusters responded to mechanical stimulation with currents that were reminiscent of immature hair cell transduction currents.
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Math1-driven GFP expression in the developing nervous system of transgenic mice
Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., et al. (2003) · Gene Expression Patterns · doi:10.1016/s1567-133x(03)00089-9 · Cited by 292
Cited by
Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
Koehler, K. R., Mikosz, A. M., Molosh, A. I., Patel, D., & Hashino, E. (2013) · Nature · doi:10.1038/nature12298 · Cited by 410
Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
Chen, W., Jongkamonwiwat, N., Abbas, L., Eshtan, S. J., Johnson, S. L., Kuhn, S., Milo, M., Thurlow, J. K., Andrews, P. W., Marcotti, W., et al. (2012) · Nature · doi:10.1038/nature11415 · Cited by 388
Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids
Lee, J., Bӧscke, R., Tang, P.-C., Hartman, B. H., Heller, S., & Koehler, K. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.007 · Cited by 187
Self-citation3D mouse embryonic stem cell culture for generating inner ear organoids
Koehler, K. R., & Hashino, E. (2014) · Nature Protocols · doi:10.1038/nprot.2014.100 · Cited by 157
Identification and characterization of mouse otic sensory lineage genes
Hartman, B. H., Durruthy-Durruthy, R., Laske, R. D., Losorelli, S., & Heller, S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00079 · Cited by 49
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Metadata
- Authors
- Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., & Heller, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 141
- Issue
- 4
- Pages
- 704-716
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2138317563
- Cited by
- 350
- References
- 2
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., & Heller, S. (2010). Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells. Cell. https://doi.org/10.1016/j.cell.2010.03.035
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