The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
Open accessAbstract
Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms of deafness, auditory neuropathy is of particular concern. This condition, defined primarily by damage to the SGNs with relative preservation of the hair cells, is responsible for a substantial proportion of patients with hearing impairment. Although the loss of hair cells can be circumvented partially by a cochlear implant, no routine treatment is available for sensory neuron loss, as poor innervation limits the prospective performance of an implant. Using stem cells to recover the damaged sensory circuitry is a potential therapeutic strategy. Here we present a protocol to induce differentiation from human embryonic stem cells (hESCs) using signals involved in the initial specification of the otic placode. We obtained two types of otic progenitors able to differentiate in vitro into hair-cell-like cells and auditory neurons that display expected electrophysiological properties. Moreover, when transplanted into an auditory neuropathy model, otic neuroprogenitors engraft, differentiate and significantly improve auditory-evoked response thresholds. These results should stimulate further research into the development of a cell-based therapy for deafness.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Rf, G. (1985) · Cited by 949
Lee, G., Kim, H., Elkabetz, Y., Al Shamy, G., Panagiotakos, G., Barberi, T., Tabar, V., & Studer, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1365 · Cited by 526
Pluripotent stem cells from the adult mouse inner ear
Li, H., Liu, H., & Heller, S. (2003) · Nature Medicine · doi:10.1038/nm925 · Cited by 464
Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells
Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., & Heller, S. (2010) · Cell · doi:10.1016/j.cell.2010.03.035 · Cited by 350
Generation of hair cells by stepwise differentiation of embryonic stem cells
Li, H., Roblin, G., Liu, H., & Heller, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334503100 · Cited by 296
Fgf3 and Fgf10 are required for mouse otic placode induction
Wright, T. J., & Mansour, S. L. (2003) · Development · doi:10.1242/dev.00555 · Cited by 288
Requirements for FGF3 and FGF10 during inner ear formation
Alvarez, Y., Alonso, M. T., Vendrell, V., Zelarayan, L. C., Chamero, P., Theil, T., Bösl, M. R., Kato, S., Maconochie, M., Riethmacher, D., et al. (2003) · Development · doi:10.1242/dev.00881 · Cited by 199
Corrales, C. E., Pan, L., Li, H., Liberman, M. C., Heller, S., & Edge, A. S. B. (2006) · Journal of Neurobiology · doi:10.1002/neu.20310 · Cited by 198
Kondo, T., Johnson, S. A., Yoder, M. C., Romand, R., & Hashino, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408239102 · Cited by 181
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Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
Koehler, K. R., Mikosz, A. M., Molosh, A. I., Patel, D., & Hashino, E. (2013) · Nature · doi:10.1038/nature12298 · Cited by 410
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
Koehler, K. R., Nie, J., Longworth-Mills, E., Liu, X.-P., Lee, J., Holt, J. R., & Hashino, E. (2017) · Nature Biotechnology · doi:10.1038/nbt.3840 · Cited by 341
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
Nyberg, S., Abbott, N. J., Shi, X., Steyger, P. S., & Dabdoub, A. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0935 · Cited by 336
3D mouse embryonic stem cell culture for generating inner ear organoids
Koehler, K. R., & Hashino, E. (2014) · Nature Protocols · doi:10.1038/nprot.2014.100 · Cited by 157
Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies
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Metadata
- Authors
- Chen, W., Jongkamonwiwat, N., Abbas, L., Eshtan, S. J., Johnson, S. L., Kuhn, S., Milo, M., Thurlow, J. K., Andrews, P. W., Marcotti, W., Moore, H. D., & Rivolta, M. N.
- Venue
- Nature
- Published
- 2012-09-12
- Volume
- 490
- Issue
- 7419
- Pages
- 278-282
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2004902965
- Cited by
- 388
- References
- 22
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, W., Jongkamonwiwat, N., Abbas, L., Eshtan, S. J., Johnson, S. L., Kuhn, S., Milo, M., Thurlow, J. K., Andrews, P. W., Marcotti, W., Moore, H. D., & Rivolta, M. N. (2012). Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature. https://doi.org/10.1038/nature11415
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