Cited by 286Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

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TGF-β Signaling Specifies Axons during Brain Development

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Yi, Jason J., Barnes, Anthony P., Hand, Randal, Polleux, Franck, Ehlers, Michael D.·2010·Cell

DOI 10.1016/j.cell.2010.06.010PMC PMC2933408

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Abstract

In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the extracellular factor(s) that initiate neuronal polarity in vivo is unknown. Here, we report that transforming growth factor beta (TGF-beta) initiates signaling pathways both in vivo and in vitro to fate naive neurites into axons. Neocortical neurons lacking the type II TGF-beta receptor (TbetaR2) fail to initiate axons during development. Exogenous TGF-beta is sufficient to direct the rapid growth and differentiation of an axon, and genetic enhancement of receptor activity promotes the formation of multiple axons. Finally, we show that the bulk of these TGF-beta-dependent events are mediated by site-specific phosphorylation of Par6. These results define an extrinsic cue for neuronal polarity in vivo that patterns neural circuits in the developing brain.

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Loeys, B., Chen, J., Neptune, E., Judge, D. P., Podowski, M., Holm, T. M., Meyers, J. L., Leitch, C. C., Katsanis, N., Sharifi, N., et al. (2005) · Nature Genetics · doi:10.1038/ng1511 · Cited by 1,786
TGF-β and epithelial-to-mesenchymal transitions
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Wrana, J. L., Attisano, L., Cárcamo, J. M., Zentella‐Dehesa, A., Doody, J. F., Laiho, M., Wang, X.-F., & Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90395-s · Cited by 1,528
Autocrine Secretion and Malignant Transformation of Cells
Sporn, M. B., & Todaro, G. J. (1980) · New England Journal of Medicine · doi:10.1056/nejm198010093031511 · Cited by 1,363
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
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Hand, R., Bortone, D., Mattar, P., Nguyen, L., Heng, J.I., Guerrier, S., Boutt, E., Peters, E., Barnes, A.P., Parras, C., et al. (2005). Neuron 48, 45–62. · DOI

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Zhao, Z., Du, J., Zhang, S., Shi, H., Chen, H., Cheng, H., Zhou, L., Yi, C., & Wang, J. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag070

Authors: Yi, J. J., Barnes, A. P., Hand, R., Polleux, F., & Ehlers, M. D.
Affiliations: Duke Medical Center (US)
University of North Carolina at Chapel Hill (US)
Howard Hughes Medical Institute (US)
Corresponding author: Ehlers, Michael D.
ORCID: Yi, Jason J.
Barnes, Anthony P.
Polleux, Franck
Ehlers, Michael D.
Venue: Cell
Publisher: Elsevier BV
Published: 2010-07
Volume: 142
Issue: 1
Pages: 144-157
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2010.06.010
PMC: PMC2933408
OpenAlex: W1991732233
Cited by: 284
References: 57
Citations by year: 2026: 12 · 2025: 5 · 2024: 10 · 2023: 15 · 2022: 18 · 2021: 30 · 2020: 26 · 2019: 15 · 2018: 11 · 2017: 16 · 2016: 13 · 2015: 20 · 2014: 15 · 2013: 24 · 2012: 28
FWCI: 9.51
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1112 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Howard Hughes Medical Institute
National Institute of Mental Health (K01MH080259)
National Institute of Neurological Disorders and Stroke (R01NS047574)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: TGF-beta signaling, axon specification, neuronal polarity, dendrite formation, TGFBR2, neocortical neurons, axon growth, neural circuit development
MeSH terms: Receptor, Transforming Growth Factor-beta Type II, Animals, Axons, Embryo, Mammalian, Neurons, Phosphorylation, Signal Transduction, Transforming Growth Factor beta, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Neocortex, Adaptor Proteins, Signal Transducing, Mice

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TGF-β Signaling Specifies Axons during Brain Development

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