Cited by 2,229Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

Noctor, Stephen C, Martínez-Cerdeño, Verónica, Ivic, Lidija, Kriegstein, Arnold R·2004·Nature Neuroscience

Abstract

Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons are generated in two proliferative zones by distinct patterns of division. Neurons arise directly from radial glial cells in the ventricular zone (VZ) and indirectly from intermediate progenitor cells in the subventricular zone (SVZ). Furthermore, newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate. These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration.

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Crossref · 10.1038/nn1172

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Authors
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R.
Affiliations
Columbia University (US)
Corresponding author
Noctor, Stephen C
Venue
Nature Neuroscience
Published
2004-01-04
Volume
7
Issue
2
Pages
136-144
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2127220436
Cited by
2,229
References
51
Citations by year
2026: 43 · 2025: 69 · 2024: 91 · 2023: 91 · 2022: 101 · 2021: 97 · 2020: 130 · 2019: 114 · 2018: 121 · 2017: 115 · 2016: 108 · 2015: 109 · 2014: 127 · 2013: 123 · 2012: 127
FWCI
21.49
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (7r37ns038658-07)
  • National Institute of Neurological Disorders and Stroke (NS-35710, NS 38658, NS-21223, R01NS021223)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
cortical neuron migration, cortical neurogenesis, radial glia, intermediate progenitor cells, ventricular zone, subventricular zone, symmetric cell division, asymmetric cell division, retrograde migration, cortical plate, cortical development
MeSH terms
Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Immunohistochemistry, Neurons, Organ Culture Techniques, Stem Cells, Patch-Clamp Techniques, Microscopy, Confocal, Rats

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