The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1
Open accessAbstract
SUMMARY Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptors required to transduce niche-derived signals. We find that SPCs lacking Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity. Aberrant mTORC1 activation in Plzf −/− SPCs inhibits their response to GDNF, a growth factor critical for SPC self-renewal, via negative feedback at the level of the GDNF receptor. Plzf opposes mTORC1 activity by inducing expression of the mTORC1 inhibitor Redd1. Thus, we identify the mTORC1-Plzf functional interaction as a critical rheostat for maintenance of the spermatogonial pool, and propose a model whereby negative feedback from mTORC1 to the GDNF receptor balances SPC growth with self-renewal.
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Cites
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019
Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
Huang, J., & Manning, B. D. (2008) · Biochemical Journal · doi:10.1042/bj20080281 · Cited by 1,237 · cited 2×
“Growth factor receptors activate mTORC1 by signaling through phosphoinositide 3-kinase (PI3K)/Akt and Ras/Erk MAPK, which inhibit the TSC1/TSC2 complex (Huang and Manning, 2008); TSC1/TSC2 negatively regulates mTORC1 via its GTPase-activating protein activity toward the small G protein Rheb.”
Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682
Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40535 · Cited by 374
Self-citationEffects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal
Ryu, B.-Y., Orwig, K. E., Oatley, J. M., Avarbock, M. R., & Brinster, R. L. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0580 · Cited by 265 · cited 1×
“In addition, the decreased sensitivity of Plzf / SPCs to GDNF mimics a reduced production of niche-signals; the decline in stem cell numbers in aging mouse testis is due partly to declining niche function and GDNF production (Ryu et al., 2006; Zhang et al., 2006), thus loss of Plzf expression can represent a premature…”
Corradetti, M. N., Inoki, K., & Guan, K.-L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c400557200 · Cited by 237 · cited 1×
“, hypoxia, DNA damage) and by developmental signals and inhibits mTORC1 through regulation of TSC1/TSC2 (Brugarolas et al., 2004; Corradetti et al., 2005; Ellisen et al., 2002).”
Mitochondrial signaling, TOR, and life span
Schieke, S. M., & Finkel, T. (2006) · Biological Chemistry · doi:10.1515/bc.2006.170 · Cited by 106
Cited by
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis
Hammoud, S. S., Low, D. H. P., Yi, C., Carrell, D. T., Guccione, E., & Cairns, B. R. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.006 · Cited by 346
CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
Ventelä, S., Côme, C., Mäkelä, J.-A., Hobbs, R. M., Mannermaa, L., Kallajoki, M., Chan, E. K., Pandolfi, P. P., Toppari, J., & Westermarck, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033209 · Cited by 58
Self-citation
Metadata
- Authors
- Hobbs, R. M., Seandel, M., Falciatori, I., Rafii, S., & Pandolfi, P. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 142
- Issue
- 3
- Pages
- 468-479
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2003819643
- Cited by
- 273
- References
- 9
- FWCI
- 19.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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