The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway

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Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone.

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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

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Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif

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Autophagy and Cell Death

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Identification of the circadian transcriptome in adult mouse skeletal muscle

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Nutrient Sensing, Metabolism, and Cell Growth Control

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Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1

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Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb

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ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

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Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

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Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

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Amino Acid Signaling in TOR Activation

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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

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RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

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Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells

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A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

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Genome-wide screen of promoter methylation identifies novel markers in melanomaPreprint

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RTP801 Is Elevated in Parkinson Brain Substantia Nigral Neurons and Mediates Death in Cellular Models of Parkinson's Disease by a Mechanism Involving Mammalian Target of Rapamycin Inactivation

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Human Muscle Gene Expression following Resistance Exercise and Blood Flow Restriction

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Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

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Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

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DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

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The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1

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Control of Translation Initiation through Integration of Signals Generated by Hormones, Nutrients, and Exercise*

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Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

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Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

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Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History

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Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

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Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis

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Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis

Kimball, S. R., Do, A. N. D., Kutzler, L., Cavener, D. R., & Jefferson, L. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706643200 · Cited by 106 · see citing works

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

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Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes

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Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

Estep, P. W., Warner, J. B., & Bulyk, M. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005242 · Cited by 93 · see citing works

Early Relapse in ALL Is Identified by Time to Leukemia in NOD/SCID Mice and Is Characterized by a Gene Signature Involving Survival Pathways

Meyer, L. H., Eckhoff, S. M., Queudeville, M., Kraus, J. M., Giordan, M., Stursberg, J., Zangrando, A., Vendramini, E., Möricke, A., Zimmermann, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.11.014 · Cited by 93 · see citing works

The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis

Russo, E., Citraro, R., Constanti, A., & Sarro, G. D. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8314-5 · Cited by 94 · see citing works

Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle

Moberg, M., Apró, W., & Blomstrand, E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00353.2011 · Cited by 90 · see citing works

Transcriptome Analysis of Wnt3a-Treated Triple-Negative Breast Cancer Cells

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Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells

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Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

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Evaluation of the siRNA PF-04523655 versus Ranibizumab for the Treatment of Neovascular Age-related Macular Degeneration (MONET Study)

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Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia

Wolff, N. C., Vega-Rubín-de-Celis, S., Xie, X., Castrillón, D. H., Kabbani, W., & Brugarolas, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01393-10 · Cited by 81 · see citing works

Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress

King, F. W., Fong, S., Griffin, C. A., Shoemaker, M., Staub, R., Zhang, Y., Cohen, I. V., & Shtivelman, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007283 · Cited by 81 · see citing works

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

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REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss

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Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response

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Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines

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Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice

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Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury

Howard, E. E., Pasiakos, S. M., Fussell, M. A., & Rodriguez, N. R. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa015 · Cited by 73 · see citing works

Is REDD1 a metabolic double agent? Lessons from physiology and pathology

Britto, F. A., Dumas, K., Giorgetti‐Peraldi, S., Ollendorff, V., & Favier, F. B. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2020 · Cited by 70 · see citing works

Paligenosis: Cellular Remodeling During Tissue Repair

Brown, J. W., Cho, C. J., & Mills, J. C. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061121-035954 · Cited by 71 · see citing works

Che‐1‐induced inhibition of mTOR pathway enables stress‐induced autophagy

Desantis, A., Bruno, T., Catena, V., Nicola, F. D., Goeman, F., Iezzi, S., Sorino, C., Ponzoni, M., Bossi, G., Federico, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201489920 · Cited by 71 · see citing works

Redox Stress and the Contributions of BH3-Only Proteins to Infarction

Webster, K. A., Graham, R. M., Thompson, J. W., Spiga, M., Frazier, D. P., Wilson, A., & Bishopric, N. H. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1667 · Cited by 71 · see citing works

Smooth Muscle–like Cells in Pulmonary Lymphangioleiomyomatosis

Krymskaya, V. P. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200705-061vs · Cited by 68 · see citing works

14-3-3 Proteins are Regulators of Autophagy

Pozuelo-Rubio, M. (2012) · Cells · doi:10.3390/cells1040754 · Cited by 67 · see citing works

Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells

Yun, S.-M., Woo, S. H., Oh, S. T., Hong, S.-E., Choe, T., Ye, S., Kim, E., Seong, M. K., Kim, H., Noh, W. C., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.11.016 · Cited by 67 · see citing works

REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch

Miyazaki, M., & Esser, K. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00464.2008 · Cited by 66 · see citing works

Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein

Lin, L., Stringfield, T. M., Shi, X., & Chen, Y. (2005) · Biochemical Journal · doi:10.1042/bj20050553 · Cited by 67 · see citing works

Hypoxia decreases macrophage glycolysis and M1 percentage by targeting microRNA‐30c and mTOR in human gastric cancer

Yun, Z., Yulin, T., Wang, Y., Wei, D., Yin, C., Xu, J.-H., Jiang, R., & Xu, X. (2019) · Cancer Science · doi:10.1111/cas.14110 · Cited by 65 · see citing works

Exploiting mTOR Signaling: A Novel Translatable Treatment Strategy for Traumatic Optic Neuropathy?

Morgan-Warren, P. J., Berry, M., Ahmed, Z., Scott, R. A. H., & Logan, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12803 · Cited by 64 · see citing works

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury

Morquette, B., Morquette, P., Agostinone, J., Feinstein, E., McKinney, R. A., Kolta, A., & Di Polo, A. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.149 · Cited by 60 · see citing works

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress

Simonson, B., Subramanya, V., Chan, M. C., Zhang, A., Franchino, H. A., Ottaviano, F. G., Mishra, M. K., Knight, A. C., Hunt, D., Ghiran, I. C., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aaf5967 · Cited by 61 · see citing works

Drugs in Phase II clinical trials for the treatment of age-related macular degeneration

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RTP801/REDD1 Regulates the Timing of Cortical Neurogenesis and Neuron Migration

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p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling through Two Independent Parallel Pathways in the Presence of DNA Damage

Cam, M., Bid, H. K., Xiao, L., Zambetti, G. P., Houghton, P. J., & Çam, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.530303 · Cited by 58 · see citing works

Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy

Álvarez-García, Ó., Olmer, M., Akagi, R., Akasaki, Y., Fisch, K. M., Shen, T., Su, A. I., & Lotz, M. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.04.015 · Cited by 57 · see citing works

RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

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Nutrient-Induced Stimulation of Protein Synthesis in Mouse Skeletal Muscle Is Limited by the mTORC1 Repressor REDD1

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Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

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RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

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Regulation of the Mechanistic Target of Rapamycin by Cellular Stress.

Magnuson, B. (2013) · Deep Blue (University of Michigan)

Transcriptional regulation of the stress response by mTOR

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TOR Signaling

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