The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
Open accessAbstract
Omega-3 fatty acids (omega-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor. Stimulation of GPR120 with omega-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown. Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without omega-3 FA supplementation. The omega-3 FA treatment inhibited inflammation and enhanced systemic insulin sensitivity in WT mice, but was without effect in GPR120 knockout mice. In conclusion, GPR120 is a functional omega-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.
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“The anti-inflammatory effects of omega-3 fatty acids seems to be mediated by binding to the G-protein–coupled receptor 120 and inhibition of NLRP3 inflammasome activity (53,54).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [53]
In the citing paper
“in macrophages and adipocytes the G-protein coupled receptor GPR120 is an omega-3 sensitive receptor that exhibits anti-inflammatory properties through the suppression of TNF-activation [141]”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [141]
In the citing paper
“GPR120 expression is negligible in skeletal muscle and would therefore not explain the changes induced by omega-3 PUFAs in tissue culture models [141]”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [141]
In the citing paper
“In summary, the n-3 PUFAs EPA and DHA can reduce inflammation via their incorporation into membrane phospholipids, where they inhibit the production of pro-inflammatory eicosanoids, reducing of activation of immune cells and the associated release of pro-inflammatory cytokines [71,97,98].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [98]
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Citations
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InfluentialSelf-citationLumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 956 · cited 8×
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InfluentialDefining high-fat-diet rat models: Metabolic and molecular effects of different fat types
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Self-citationMuscle-specific Pparg deletion causes insulin resistance
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Self-citationTAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway
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InfluentialRoles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions.
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Polyunsaturated fatty acids and inflammation
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InfluentialIdentification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB Pathways
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The regulation of adipogenesis through GPR120
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“GPR120 is also expressed in enteroendocrine L cells with negligible expression in muscle (Figure S4C available online), hepatocytes or other cell types (Hirasawa et al., 2005; Gotoh et al., 2007).”
InfluentialNeschen, S., Morino, K., Dong, J., Wang-Fischer, Y., Cline, G. W., Romanelli, A. J., Rossbacher, J. C., Moore, I. K., Regittnig, W., Muñoz, D. S., et al. (2007) · Diabetes · doi:10.2337/db06-1206 · Cited by 236 · cited 1×
“After 15 weeks on HFD, WT and GPR120 KO mice were switched to an isocaloric HFD-containing 27% menhaden fish oil replacement (wt/wt; menhaden fish oil: 16% EPA (C20:5n3), 9%, DHA (C22:6n3), Research Diet) (Jucker et al., 1999; Neschen et al., 2007) and fed for 5 weeks.”
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G Alpha-q/11 Protein Plays a Key Role in Insulin-Induced Glucose Transport in 3T3-L1 Adipocytes
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“…Gaq/11 knockdown not only inhibited DHA andGW9508 stimulated glucose transport, but it also attenuated insulin stimulatory effects, and the latter is fully consistent with previous publication (Imamura et al., 1999) showing the role of Gaq/11 in insulin signaling to glucose transport in adipocytes.”
InfluentialSelf-citationTerrillon, S., Barberis, C., & Bouvier, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305322101 · Cited by 158
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Self-citationFan, W., Imamura, T., Sonoda, N., Sears, D. D., Patsouris, D., Kim, J. J., & Olefsky, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808915200 · Cited by 133
Self-citationJucker, B. M., Cline, G. W., Barucci, N., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.1.134 · Cited by 119 · cited 3×
“After 15 weeks on HFD, WT and GPR120 KO mice were switched to an isocaloric HFD-containing 27% menhaden fish oil replacement (wt/wt; menhaden fish oil: 16% EPA (C20:5n3), 9%, DHA (C22:6n3), Research Diet) (Jucker et al., 1999; Neschen et al., 2007) and fed for 5 weeks.”
InfluentialBone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance
Lesniewski, L. A., Hosch, S. E., Neels, J. G., de Luca, C., Pashmforoush, M., Lumeng, C. N.-K., Chiang, S.-H., Scadeng, M., Saltiel, A. R., & Olefsky, J. M. (2007) · Nature Medicine · doi:10.1038/nm1550 · Cited by 114
Self-citationYoshizaki, T., Imamura, T., Babendure, J. L., Lu, J.-C., Sonoda, N., & Olefsky, J. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02298-06 · Cited by 112
Self-citationPatsouris, D., Neels, J. G., Fan, W., Li, P., Nguyen, M. T., & Olefsky, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041665 · Cited by 80
Self-citationCen, B., Xiong, Y., Ma, L., & Pei, G. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.758 · Cited by 75 · cited 1×
“Primer sequences are shown in Table S1. putative b-arrestin2 binding motifs [(S/T)X4-5(S/T); Cen et al., 2001], but whether b-arrestins play any role in GPR120 function was unknown.”
Polozova, A., & Salem, N. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0039-y · Cited by 60 · cited 1×
“In conclusion, GPR120 is a functional u-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.”
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“Since GPR120 is a Gaq/11coupled receptor, it stimulates both PKC and MAP kinase, and both of these biologic effects are detected by the SRE-driven reporter system (Oh et al., 2005).”
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Metadata
- Authors
- Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M.
- Affiliations
- University of California San Diego (US)
- Shiga University of Medical Science (JP)
- Corresponding author
- Olefsky, Jerrold M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 5
- Pages
- 687-698
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2956412
- OpenAlex
- W2131094572
- Cited by
- 2,428
- References
- 49
- Citations by year
- 2026: 97 · 2025: 134 · 2024: 123 · 2023: 129 · 2022: 134 · 2021: 180 · 2020: 172 · 2019: 157 · 2018: 158 · 2017: 181 · 2016: 197 · 2015: 177 · 2014: 165 · 2013: 162 · 2012: 143
- FWCI
- 127.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIDDK DK033651, DK 074868, DK063491, U54 HD 012303-25)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- GPR120, docosahexaenoic acid, eicosapentaenoic acid, anti-inflammatory activity, insulin sensitivity, insulin resistance, macrophage inflammation, obesity, high-fat diet, G protein-coupled receptors, RAW 264.7 macrophages
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Dietary Fats, Humans, Hypoglycemic Agents, Insulin Resistance, Macrophages, Obesity, Fatty Acids, Omega-3, Mice, Knockout, Dietary Supplements, 3T3-L1 Cells, Receptors, G-Protein-Coupled, Mice
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