The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting
Open accessAbstract
SUMMARY The peripheral nervous system has astonishing regenerative capabilities in that cut nerves are able to reconnect and re-establish their function. Schwann cells are important players in this process, during which they dedifferentiate to a progenitor/stem cell and promote axonal regrowth. Here, we report that fibroblasts also play a key role. Upon nerve cut, ephrin-B/EphB2 signaling between fibroblasts and Schwann cells results in cell sorting, followed by directional collective cell migration of Schwann cells out of the nerve stumps to guide regrowing axons across the wound. Mechanistically, we find that cell-sorting downstream of EphB2 is mediated by the stemness factor Sox2 through N-cadherin relocalization to Schwann cell-cell contacts. In vivo, loss of EphB2 signaling impaired organized migration of Schwann cells, resulting in misdirected axonal regrowth. Our results identify a link between Ephs and Sox proteins, providing a mechanism by which progenitor cells can translate environmental cues to orchestrate the formation of new tissue.
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Self-citationRole of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury
Chen, P., Piao, X., & Bonaldo, P. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1482-4 · Cited by 520
The Success and Failure of the Schwann Cell Response to Nerve Injury
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Eph Receptor Signaling and Ephrins
Lisabeth, E. M., Falivelli, G., & Pasquale, E. B. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009159 · Cited by 425
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Metadata
- Authors
- Parrinello, S., Napoli, I., Ribeiro, S., Digby, P. W., Fedorova, M., Parkinson, D. B., Doddrell, R. D. S., Nakayama, M., Adams, R. H., & Lloyd, A. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 143
- Issue
- 1
- Pages
- 145-155
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2050935187
- Cited by
- 493
- References
- 35
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Parrinello, S., Napoli, I., Ribeiro, S., Digby, P. W., Fedorova, M., Parkinson, D. B., Doddrell, R. D. S., Nakayama, M., Adams, R. H., & Lloyd, A. C. (2010). EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting. Cell. https://doi.org/10.1016/j.cell.2010.08.039
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