The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance
Open accessAbstract
SUMMARY Reproductive cessation is perhaps the earliest aging phenotypes humans experience. Similarly, C. elegans’ reproduction ceases in mid-adulthood. Although somatic aging has been studied in both worms and humans, mechanisms regulating reproductive aging are not yet understood. Here we show that TGF-β Sma/Mab and Insulin/IGF-1 signaling regulate C. elegans reproductive aging by modulating multiple aspects of the reproductive process, including embryo integrity, oocyte fertilizability, chromosome segregation fidelity, DNA damage resistance, and oocyte and germline morphology. TGF-β activity regulates reproductive span and germline/oocyte quality non-cell-autonomously, and is temporally and transcriptionally separable from its regulation of growth. Chromosome segregation, cell cycle, and DNA damage response genes are upregulated in TGF-β mutant oocytes, decline in aged mammalian oocytes, and are critical for oocyte quality maintenance. Our data suggest that C. elegans and humans share many aspects of reproductive aging, including the correlation between reproductive aging and declining oocyte quality, and mechanisms determining oocyte quality.
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Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Functionally significant insulin-like growth factor I receptor mutations in centenarians
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Genetic variation in LIN28B is associated with the timing of puberty
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Cited by
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Self-citationAging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish
Reichwald, K., Petzold, A., Koch, P., Downie, B. R., Hartmann, N., Pietsch, S., Baumgart, M., Chalopin, D., Felder, M., Bens, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.071 · Cited by 323
Indoles from commensal bacteria extend healthspan
Sonowal, R., Swimm, A., Sahoo, A., Luo, L., Matsunaga, Y., Wu, Z., Bhingarde, J. A., Ejzak, E. A., Ranawade, A., Qadota, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706464114 · Cited by 197
DNA damage in aging, the stem cell perspective
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“elegans DDR gene expression Altered with age in oocytes Luo et al. (2010)”
Background
Metadata
- Authors
- Luo, S., Kleemann, G. A., Ashraf, J. M., Shaw, W. M., & Murphy, C. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 143
- Issue
- 2
- Pages
- 299-312
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2055937273
- Cited by
- 283
- References
- 6
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luo, S., Kleemann, G. A., Ashraf, J. M., Shaw, W. M., & Murphy, C. T. (2010). TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance. Cell. https://doi.org/10.1016/j.cell.2010.09.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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