DNA damage in aging, the stem cell perspective
Open accessAbstract
DNA damage is one of the most consistent cellular process proposed to contribute to aging. The maintenance of genomic and epigenomic integrity is critical for proper function of cells and tissues throughout life, and this homeostasis is under constant strain from both extrinsic and intrinsic insults. Considering the relationship between lifespan and genotoxic burden, it is plausible that the longest-lived cellular populations would face an accumulation of DNA damage over time. Tissue-specific stem cells are multipotent populations residing in localized niches and are responsible for maintaining all lineages of their resident tissue/system throughout life. However, many of these stem cells are impacted by genotoxic stress. Several factors may dictate the specific stem cell population response to DNA damage, including the niche location, life history, and fate decisions after damage accrual. This leads to differential handling of DNA damage in different stem cell compartments. Given the importance of adult stem cells in preserving normal tissue function during an individual's lifetime, DNA damage sensitivity and accumulation in these compartments could have crucial implications for aging. Despite this, more support for direct functional effects driven by accumulated DNA damage in adult stem cell compartments is needed. This review will present current evidence for the accumulation and potential influence of DNA damage in adult tissue-specific stem cells and propose inquiry directions that could benefit individual healthspan.
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DNA damage and DDR activation markers occur in many stem cell types across tissues and species during normal and pathological ageing, indicating that stem cells can accumulate DNA damage and activate the DDR.
“DNA damage and markers of DDR activation have been observed in various stem cell types in different tissues and species, during normal and pathological ageing121,122, suggesting that stem cells are not immune to DNA damage accumulation and DDR activation123.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [122]
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Self-citationNfatc1 orchestrates aging in hair follicle stem cells
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“To the contrary, more recent evidence has shown increased levels of DNA damage in satellite cells isolated from aged mice (Liu et al. 2018; Sinha et al. 2014) (Table 1).”
ResultEffect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
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DNA damage drives accelerated bone aging via an NF- <b>κ</b> B–dependent mechanism
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“NER (Ercc1−/−/Ercc1−/Δ) Accelerated osteoporosis accompanied by progenitor senescence and accumulation of DNA damage Chen et al. (2013), Niedernhofer et al. (2006)”
BackgroundInfluentialReduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice
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“Mice with deficient nucleotide excision repair, homologous recombination, and non-homologous recombination pathways showed various aging HSC phenotypes under transplant paradigms (Nijnik et al. 2007; Prasher et al. 2005; Rossi et al. 2007).”
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“Human Mutations in progeny Increase with both parental and maternal age Risch et al. (1987), Kong et al.”
BackgroundDefining the clonal dynamics leading to mouse skin tumour initiation
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“Similarly, in humans, functional impairment of old satellite cells was associated with loss of genomic stability (Franco et al. 2018).”
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SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
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Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
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Different responses to DNA damage determine ageing differences between organs
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GelMA ‐based hydrogel biomaterial scaffold: A versatile platform for regenerative endodontics
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A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity
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Germline stem cell aging in the Drosophila ovary
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“accelerant of the aging cascade that has been reviewed in the context of stem cell aging before [33].”
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ROS-Induced DNA Damage as an Underlying Cause of Aging
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“Another approach is to increase genome maintenance by artificially promoting the DDR signaling cascade, as proposed by Gioia et al. [59], although caution should be taken because, paradoxically, chronic DDR activation can accelerate aging by inducing senescence.”
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“When the cells are exposed to radiation, it will cause base modifications and DNA breaks, and various pathways are involved in maintaining the genetic integrity (Goldstein and Kastan 2015; Barnes et al. 2019; McNeely et al. 2020).”
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“Moreover, oxidative stress induces DNA damage and telomere dysfunction is an important mechanism of cell senescence [59 – 64].”
Age-related cognitive decline in rats is sex and context dependent
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“To solve this, many cells from diverse histological origins are conserved in the DNA damage repair (DDR) pathways (7, 8).”
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DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress
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“…profile, genomic integrity, and aging is especially important in the context of human age-related diseases, as the evident age-related accrual of DNA damage [25] can result in somatic mutations in the progenitor compartment [26–29] that could contribute to clonal expansion and disease [30–33].”
Self-citationAdvances in understanding the molecular basis of clonal hematopoiesis
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Proliferation: Driver of HSC aging phenotypes?
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“In HSCs, it seems that DNA damage is an aging mechanism (McNeely et al., 2019).”
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Hematopoietic aging: Cellular, molecular, and related mechanisms
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“[2] In this review, we analyze the precise relationships between niche and HSC and aging by summarizing the causes of, markers of, and signalling pathways related to hematopoietic aging.”
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Drosophila model systems reveal intestinal stem cells as key players in aging
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From microscopic damage to macroscopic games: a dimensionality reduction of stem cell homeostasis
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“Differentiated cells can revert to a proliferative stage through ded-ifferentiation to replace lost tissue [14], [15].”
Antiinflammatory therapy as a game-changer toward antiaging
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“It was once believed that DNA damage would lead to HSC senescence [1, 4].”
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“…fi ed, including a signi fi cant decrease in the number of quiescent HSC cells (i.e., G0 phase) (17); accumulation of DNA damage and mutations in HSCs (18 – 20); a decrease in self-renewal capacity; impaired hematopoietic reconstitution; clonal proliferation; and myeloid-biased hematopoiesis (21).”
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A Multilevel Approach to the Causes of Genetic Instability in Stem Cells
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A Multilevel Approach to the Causes of Genetic Instability in Stem Cells
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- Authors
- McNeely, T., Leone, M., Yanai, H., & Beerman, I.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Beerman, Isabel
- Venue
- Human Genetics
- Published
- 2019-07-19
- Volume
- 139
- Issue
- 3
- Pages
- 309-331
- ISSN
- 0018-7348 (ISSN-L)
- 0340-6717
- 1432-1203
- PMC
- PMC6980431
- OpenAlex
- W2962795074
- Semantic Scholar
- e941bddd222e771b8a09dabfd854113fc588a2ed
- Cited by
- 52
- References
- 274
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 14 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 10
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIA / NIH Intramural Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- DNA damage, aging, adult stem cells, genotoxic stress, stem cell niche, genome stability, lifespan, healthspan, stem cell fate
- MeSH terms
- Aging, Animals, DNA Damage, Homeostasis, Humans, Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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