Indoles from commensal bacteria extend healthspan
Open accessAbstract
Significance: Increases in human life expectancy over the next century will be accompanied by increased frailty and massive and unsustainable health care costs. Developing means to extend the time that individuals remain healthy and free of age-related infirmities, called healthspan, has therefore become a critical goal of aging research. We show that small molecules produced by the microbiota and related to indole extend healthspan in geriatric worms, flies, and mice, without attendant effects on lifespan. Indoles act via the aryl hydrocarbon receptor and cause animals to retain a youthful gene expression profile. Indoles may represent a new class of therapeutics that improve the way we age as opposed to simply extending how long we live.
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Healthy ageing correlates with increased indoles, gut bacterial tryptophan degradation products that mediate immune homeostasis via aryl hydrocarbon and IL-10 receptors.
“healthy ageing correlates with an increased presence of certain indoles, which are gut bacterial degradation products of tryptophan that mediate immune homeostasis upon binding to aryl hydrocarbon receptors and IL-10 receptors15–17”
From Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy (2023) · cites this paper as [16]
Recent animal studies have shown that metabolic byproducts of intestinal bacteria have great relevance in prolonging healthspan.
“and that the metabolic byproducts of intestinal bacteria have a great relevance in prolonging healthspan [140].”
From Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia (2019) · cites this paper as [140]
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- Authors
- Sonowal, R., Swimm, A., Sahoo, A., Luo, L., Matsunaga, Y., Wu, Z., Bhingarde, J. A., Ejzak, E. A., Ranawade, A., Qadota, H., Powell, D. N., Capaldo, C. T., Flacker, J. M., Jones, R. M., Benian, G. M., & Kalman, D.
- Affiliations
- Emory University (US)
- McMaster University (CA)
- Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322;
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-08-21
- Volume
- 114
- Issue
- 36
- Pages
- E7506-E7515
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5594673
- OpenAlex
- W2747253994
- Cited by
- 197
- References
- 70
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 28 · 2023: 15 · 2022: 30 · 2021: 23 · 2020: 30 · 2019: 12 · 2018: 18 · 2017: 2
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (2R01DK074731)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- indole, commensal bacteria, gut microbiota, healthspan, healthy aging, aging, fecundity, oogenesis, reproductive period, frailty, gene expression
- MeSH terms
- Aging, Animals, Bacteria, Drosophila melanogaster, Indoles, Longevity, Mice, Inbred BALB C, Mice, Inbred C57BL, Mutation, Reproduction, Caenorhabditis elegans, Receptors, Aryl Hydrocarbon, Caenorhabditis elegans Proteins, Mice, Transcriptome
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