The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence
Open accessAbstract
The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control.
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Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
PTEN negatively regulates neural stem cell self-renewal by modulating G 0 -G 1 cell cycle entry
Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., & Wu, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509939103 · Cited by 306
Cited by
Drosophila neuroblasts: a model for stem cell biology
Homem, C. C. F., & Knoblich, J. A. (2012) · Development · doi:10.1242/dev.080515 · Cited by 476
Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development
Morin, X., & Bellaïche, Y. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.012 · Cited by 423
Drosophila Central Nervous System Glia
Freeman, M. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020552 · Cited by 309
The Drosophila blood-brain barrier: development and function of a glial endothelium
Limmer, S., Weiler, A., Volkenhoff, A., Babatz, F., & Klämbt, C. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00365 · Cited by 214
Truman, J. W., & Riddiford, L. M. (2023) · GENETICS · doi:10.1093/genetics/iyac184 · Cited by 60
Metadata
- Authors
- Chell, J. M., & Brand, A. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 143
- Issue
- 7
- Pages
- 1161-1173
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2061428578
- Cited by
- 412
- References
- 2
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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