Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development
Open accessAbstract
The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible implications in tissue morphogenesis. Many recent studies show that future advances in the field of mitotic spindle orientation will arise from combinations of physical perturbation and modeling with classical genetics and developmental biology approaches.
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The different cell cycle characteristics of daughter cells are reminiscent of asymmetric cell fate in Drosophila and mammals.
“a feature that is reminiscent of asymmetric cell fate in Drosophila and mammals [72].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [72]
Cites
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
Farhadifar, R., Röper, J.-C., Aigouy, B., Eaton, S., & Jülicher, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.049 · Cited by 1,254 · see citing works
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013 · see citing works
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998 · see citing works
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830 · see citing works
The extracellular matrix guides the orientation of the cell division axis
Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J., & Bornens, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1307 · Cited by 780 · see citing works
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766 · see citing works
Munro, E., Nance, J., & Priess, J. R. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.001 · Cited by 746 · see citing works
Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila
Aigouy, B., Farhadifar, R., Staple, D. B., Sagner, A., Röper, J.-C., Jülicher, F., & Eaton, S. (2010) · Cell · doi:10.1016/j.cell.2010.07.042 · Cited by 692 · see citing works
The organization and cell-lineage of the ascidian egg
CONKLIN, E. G. (1905) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5962/bhl.title.4801 · Cited by 631 · see citing works
Conservation of the Notch signalling pathway in mammalian neurogenesis
de la Pompa, J. L., Wakeham, A. C., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., et al. (1997) · Development · doi:10.1242/dev.124.6.1139 · Cited by 624 · see citing works
A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly
Merdes, A., Ramyar, K. X., Vechio, J. D., & Cleveland, D. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81365-3 · Cited by 570 · see citing works
Asymmetric cell division: recent developments and their implications for tumour biology
Knoblich, J. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3010 · Cited by 568 · see citing works
Principles of planar polarity in animal development
Goodrich, L. V., & Strutt, D. I. (2011) · Development · doi:10.1242/dev.054080 · Cited by 568 · see citing works
Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division
Yamashita, Y. M., Mahowald, A. P., Perlin, J. R., & Fuller, M. T. (2007) · Science · doi:10.1126/science.1134910 · Cited by 561 · see citing works
Defective planar cell polarity in polycystic kidney disease
Fischer, E. A., Legué, E., Doyen, A., Nato, F., Nicolas, J.-F., Torres, V. E., Yaniv, M., & Pontoglio, M. (2005) · Nature Genetics · doi:10.1038/ng1701 · Cited by 534 · see citing works
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
Saburi, S., Hester, I., Fischer, E. A., Pontoglio, M., Eremina, V., Gessler, M., Quaggin, S., Harrison, R. V., Mount, R. J., & McNeill, H. (2008) · Nature Genetics · doi:10.1038/ng.179 · Cited by 517 · see citing works
Grill, S. W., Gönczy, P., Stelzer, E. H. K., & Hyman, A. A. (2001) · Nature · doi:10.1038/35054572 · Cited by 511 · see citing works
A new subtype of progenitor cell in the mouse embryonic neocortex
Wang, X., Tsai, J.-W., LaMonica, B., & Kriegstein, A. R. (2011) · Nature Neuroscience · doi:10.1038/nn.2807 · Cited by 507 · see citing works
Uemura, T., Younger-Shepherd, S., Ackerman, L. D., Jan, L. Y., & Jan, Y. N. (1989) · Cell · doi:10.1016/0092-8674(89)90849-0 · Cited by 505 · see citing works
Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
Shinin, V., Gayraud-Morel, B., Gomès, D., & Tajbakhsh, S. (2006) · Nature Cell Biology · doi:10.1038/ncb1425 · Cited by 504 · see citing works
Konno, D., Shioi, G., Shitamukai, A., Mori, A., Kiyonari, H., Miyata, T., & Matsuzaki, F. (2007) · Nature Cell Biology · doi:10.1038/ncb1673 · Cited by 502 · see citing works
Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows
Mayer, M., Depken, M., Bois, J. S., Jülicher, F., & Grill, S. W. (2010) · Nature · doi:10.1038/nature09376 · Cited by 496 · see citing works
Mechanisms of asymmetric cell division: flies and worms pave the way
Gönczy, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2388 · Cited by 487 · see citing works
Asymmetric centrosome inheritance maintains neural progenitors in the neocortex
Wang, X., Tsai, J., Imai, J. H., Lian, W.-N., Vallee, R. B., & Shi, S. (2009) · Nature · doi:10.1038/nature08435 · Cited by 477 · see citing works
Spindle orientation during asymmetric cell division
Siller, K. H., & Doe, C. Q. (2009) · Nature Cell Biology · doi:10.1038/ncb0409-365 · Cited by 474 · see citing works
Shitamukai, A., Konno, D., & Matsuzaki, F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4773-10.2011 · Cited by 450 · see citing works
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Caussinus, E., & González, C. (2005) · Nature Genetics · doi:10.1038/ng1632 · Cited by 445 · see citing works
The emergence of geometric order in proliferating metazoan epithelia
Gibson, M. C., Patel, A. B., Nagpal, R., & Perrimon, N. (2006) · Nature · doi:10.1038/nature05014 · Cited by 435 · see citing works
Kosodo, Y., Röper, K., Haubensak, W. E., Marzesco, A., Corbeil, D., & Huttner, W. Β. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600223 · Cited by 435 · see citing works
Etemad-Moghadam, B., Guo, S., & Kemphues, K. J. (1995) · Cell · doi:10.1016/0092-8674(95)90187-6 · Cited by 427 · see citing works
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
Fish, J. L., Kosodo, Y., Enard, W., Pääbo, S., & Huttner, W. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604066103 · Cited by 421 · see citing works
Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation
Gong, Y., Mo, C., & Fraser, S. E. (2004) · Nature · doi:10.1038/nature02796 · Cited by 420 · see citing works
Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence
Chell, J. M., & Brand, A. H. (2010) · Cell · doi:10.1016/j.cell.2010.12.007 · Cited by 416 · see citing works
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
Noctor, S. C., Martínez‐Cerdeño, V., & Kriegstein, A. R. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21669 · Cited by 415 · see citing works
Experimental and theoretical study of mitotic spindle orientation
Théry, M., Jiménez-Dalmaroni, A., Racine, V., Bornens, M., & Jülicher, F. (2007) · Nature · doi:10.1038/nature05786 · Cited by 406 · see citing works
Asymmetric cell divisions promote Notch-dependent epidermal differentiation
Williams, S. E., Beronja, S., Pasolli, H. A., & Fuchs, E. (2011) · Nature · doi:10.1038/nature09793 · Cited by 406 · see citing works
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
Sousa‐Nunes, R., Yee, L. L., & Gould, A. P. (2011) · Nature · doi:10.1038/nature09867 · Cited by 406 · see citing works
Planar cell polarity signalling couples cell division and morphogenesis during neurulation
Ciruna, B. G., Jenny, A., Lee, D. W., Mlodzik, M., & Schier, A. F. (2006) · Nature · doi:10.1038/nature04375 · Cited by 400 · see citing works
Role of inscuteable in orienting asymmetric cell divisions in Drosophila
Kraut, R. S., Chia, W. N., Jan, L. Y., Jan, Y. N., & Knoblich, J. A. (1996) · Nature · doi:10.1038/383050a0 · Cited by 394 · see citing works
Influence of Cell Geometry on Division-Plane Positioning
Minc, N., Burgess, D. R., & Chang, F. (2011) · Cell · doi:10.1016/j.cell.2011.01.016 · Cited by 381 · see citing works
Yu, F., Morin, X., Cai, Y., Yang, X., & Chia, W. N. (2000) · Cell · doi:10.1016/s0092-8674(00)80676-5 · Cited by 370 · see citing works
Self-citationMammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins
Du, Q., & Macara, I. G. (2004) · Cell · doi:10.1016/j.cell.2004.10.028 · Cited by 370 · see citing works
The Distribution of Active Force Generators Controls Mitotic Spindle Position
Grill, S. W., Howard, J., Schäffer, E., Stelzer, E. H. K., & Hyman, A. A. (2003) · Science · doi:10.1126/science.1086560 · Cited by 362 · see citing works
The 3Ms of central spindle assembly: microtubules, motors and MAPs
Glotzer, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2609 · Cited by 360 · see citing works
Mitotic Spindle Regulation by Nde1 Controls Cerebral Cortical Size
Feng, Y., & Walsh, C. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.023 · Cited by 353 · see citing works
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein.
Toba, S., Watanabe, T. M., Yamaguchi-Okimoto, L., Toyoshima, Y., & Higuchi, H. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0508511103 · Cited by 339 · see citing works
Schaefer, M., Shevchenko, A., Shevchenko, A., & Knoblich, J. A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00401-2 · Cited by 337 · see citing works
The Orientation of Cell Divisions Determines the Shape of Drosophila Organs
Baena-López, L. A., Baonza, A., & Garcı́a-Bellido, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.062 · Cited by 332 · see citing works
Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
Ikeshima‐Kataoka, H., Skeath, J. B., Nabeshima, Y., Doe, C. Q., & Matsuzaki, F. (1997) · Nature · doi:10.1038/37641 · Cited by 331 · see citing works
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts
Siller, K. H., Cabernard, C., & Doe, C. Q. (2006) · Nature Cell Biology · doi:10.1038/ncb1412 · Cited by 315 · see citing works
The Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division
Bowman, S., Neumüller, R. A., Novatchkova, M., Du, Q., & Knoblich, J. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.05.005 · Cited by 303 · see citing works
Théry, M., & Bornens, M. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.001 · Cited by 296 · see citing works
Mechanics and remodelling of cell packings in epithelia
Staple, D. B., Farhadifar, R., Röper, J. C., Aigouy, B., Eaton, S., & Jülicher, F. (2010) · The European Physical Journal E · doi:10.1140/epje/i2010-10677-0 · Cited by 294 · see citing works
Rebollo, E., Sampaio, P., Januschke, J., Llamazares, S., Varmark, H., & González, C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.01.021 · Cited by 291 · see citing works
Kaltschmidt, J. A., Davidson, C. M., Brown, N. H., & Brand, A. H. (1999) · Nature Cell Biology · doi:10.1038/71323 · Cited by 288 · see citing works
Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis
Godin, J. D., Colombo, K., Molina-Calavita, M., Keryer, G., Zala, D., Charrin, B. C., Dietrich, P., Volvert, M.-L., Guillemot, F., Dragatsis, I., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.027 · Cited by 287 · see citing works
Self-citationTranslation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos
Colombo, K., Grill, S. W., Kimple, R. J., Willard, F. S., Siderovski, D. P., & Gönczy, P. (2003) · Science · doi:10.1126/science.1084146 · Cited by 285 · see citing works
Force production by disassembling microtubules
Grishchuk, E. L., Molodtsov, M. I., Ataullakhanov, F. I., & McIntosh, J. R. (2005) · Nature · doi:10.1038/nature04132 · Cited by 284 · see citing works
Yingling, J., Youn, Y. H., Darling, D. L., Toyo‐oka, K., Pramparo, T., Hirotsune, S., & Wynshaw-Boris, A. J. (2008) · Cell · doi:10.1016/j.cell.2008.01.026 · Cited by 271 · see citing works
Gho, M., Bellaı̈che, Y., & Schweisguth, F. (1999) · Development · doi:10.1242/dev.126.16.3573 · Cited by 270 · see citing works
Self-citationA mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization
Du, Q., Stukenberg, P. T., & Macara, I. G. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-1069 · Cited by 262 · see citing works
Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization
Izumi, Y., Ohta, N., Hisata, K., Raabe, T., & Matsuzaki, F. (2006) · Nature Cell Biology · doi:10.1038/ncb1409 · Cited by 259 · see citing works
Microtubule-Induced Pins/Gαi Cortical Polarity in Drosophila Neuroblasts
Siegrist, S. E., & Doe, C. Q. (2005) · Cell · doi:10.1016/j.cell.2005.09.043 · Cited by 255 · see citing works
A role for a novel centrosome cycle in asymmetric cell division
Rusan, N. M., & Peifer, M. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612140 · Cited by 255 · see citing works
Spindle Positioning by Cortical Pulling Forces
Grill, S. W., & Hyman, A. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.014 · Cited by 252 · see citing works
Bellaı̈che, Y., Gho, M., Kaltschmidt, J. A., Brand, A. H., & Schweisguth, F. (2000) · Nature Cell Biology · doi:10.1038/35050558 · Cited by 252 · see citing works
Self-citationMorphogen Control of Wing Growth through the Fat Signaling Pathway
Rogulja, D., Rauskolb, C., & Irvine, K. D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.06.003 · Cited by 251 · see citing works
Busson, S., Dujardin, D., Moreau, A., Dompierre, J., & Mey, J. D. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70208-8 · Cited by 247 · see citing works
Morin, X., Jaouen, F., & Durbec, P. L. (2007) · Nature Neuroscience · doi:10.1038/nn1984 · Cited by 245 · see citing works
Self-citationFour-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains
Ishikawa, H., Takeuchi, H., Haltiwanger, R. S., & Irvine, K. D. (2008) · Science · doi:10.1126/science.1158159 · Cited by 243 · see citing works
Coupling of cortical dynein and Gα proteins mediates spindle positioning in Caenorhabditis elegans
Nguyen‐Ngoc, T., Afshar, K., & Gönczy, P. (2007) · Nature Cell Biology · doi:10.1038/ncb1649 · Cited by 239 · see citing works
Gotta, M., Yan, D., Peterson, Y. K., Lanier, S. M., & Ahringer, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00371-3 · Cited by 239 · see citing works
Yu, J. Q., Carroll, T. J., Rajagopal, J., Kobayashi, A., Ren, Q., & McMahon, A. P. (2008) · Development · doi:10.1242/dev.022087 · Cited by 238 · see citing works
Concha, M. L., & Adams, R. J. (1998) · Development · doi:10.1242/dev.125.6.983 · Cited by 237 · see citing works
Srayko, M., Kaya-Çopur, A., Stamford, J., & Hyman, A. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.003 · Cited by 233 · see citing works
A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C. elegansPreprint
Srinivasan, D. G., Fisk, R. M., Xu, H., & van den Heuvel, S. (2003) · Genes & Development · doi:10.1101/gad.1081203 · Cited by 231 · see citing works
Gho, M., & Schweisguth, F. (1998) · Nature · doi:10.1038/30265 · Cited by 230 · see citing works
Orchestrating size and shape during morphogenesis
Lecuit, T., & LeGoff, L. (2007) · Nature · doi:10.1038/nature06304 · Cited by 230 · see citing works
Par3 Controls Epithelial Spindle Orientation by aPKC-Mediated Phosphorylation of Apical Pins
Hao, Y., Du, Q., Chen, X., et al. (2010) · Current Biology · doi:10.1016/j.cub.2010.09.032 · Cited by 229 · see citing works
Cortical Microtubule Contacts Position the Spindle in C. elegans Embryos
Kozlowski, C., Srayko, M., & Nédélec, F. (2007) · Cell · doi:10.1016/j.cell.2007.03.027 · Cited by 228 · see citing works
Bellaı̈che, Y., Radovic, A., Woods, D. F., Hough, C. D., Parmentier, M., O’Kane, C. J., Bryant, P. J., & Schweisguth, F. (2001) · Cell · doi:10.1016/s0092-8674(01)00444-5 · Cited by 228 · see citing works
Self-citationMao, Y., Rauskolb, C., Cho, E., Hu, W.-L., Hayter, H., Minihan, G., Katz, F. N., & Irvine, K. D. (2006) · Development · doi:10.1242/dev.02427 · Cited by 221 · see citing works
A Model for Cleavage Plane Determination in Early Amphibian and Fish Embryos
Wühr, M., Tan, E. S., Parker, S. K., et al. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.024 · Cited by 218 · see citing works
A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis
Tawk, M., Araya, C., Lyons, D. A., Reugels, A. M., Girdler, G. C., Bayley, P. R., Hyde, D. R., Tada, M., & Clarke, J. D. W. (2007) · Nature · doi:10.1038/nature05722 · Cited by 217 · see citing works
Planar polarization of the atypical myosin Dachs orients cell divisions in DrosophilaPreprint
Mao, Y., Tournier, A., Bates, P. A., et al. (2011) · Genes & Development · doi:10.1101/gad.610511 · Cited by 217 · see citing works
Reinsch, S. S., & Karsenti, E. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.6.1509 · Cited by 215 · see citing works
Johnston, C. A., Hirono, K., Prehoda, K. E., & Doe, C. Q. (2009) · Cell · doi:10.1016/j.cell.2009.07.041 · Cited by 212 · see citing works
Dujardin, D., & Vallee, R. B. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(01)00292-7 · Cited by 204 · see citing works
Drosophila neuroblasts retain the daughter centrosome
Januschke, J., Llamazares, S., Reina, J., & González, C. (2011) · Nature Communications · doi:10.1038/ncomms1245 · Cited by 196 · see citing works
RIC-8 Is Required for GPR-1/2-Dependent Gα Function during Asymmetric Division of C. elegans Embryos
Afshar, K., Willard, F. S., Colombo, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.026 · Cited by 191 · see citing works
Control of the Mitotic Cleavage Plane by Local Epithelial Topology
Gibson, W. T., Veldhuis, J. H., RUBINSTEIN, B. Y., Cartwright, H. N., Perrimon, N., Brodland, G. W., Nagpal, R., & Gibson, M. C. (2011) · Cell · doi:10.1016/j.cell.2010.12.035 · Cited by 188 · see citing works
The Fat and Warts signaling pathways: new insights into their regulation,mechanism and conservation
Reddy, B. V. V. G., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.020974 · Cited by 187 · see citing works
LGN regulates mitotic spindle orientation during epithelial morphogenesis
Zheng, Z., Zhu, H., Wan, Q., Liu, J., Xiao, Z., Siderovski, D. P., & Du, Q. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200910021 · Cited by 179 · see citing works
Pécréaux, J., Röper, J.-C., Kruse, K., Jülicher, F., Hyman, A. A., Grill, S. W., & Howard, J. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.030 · Cited by 174 · see citing works
Yu, F., Kuo, C. T., & Jan, Y. N. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.016 · Cited by 173 · see citing works
Theory of Mitotic Spindle Oscillations
Grill, S. W., Kruse, K., & Jülicher, F. (2005) · Physical Review Letters · doi:10.1103/physrevlett.94.108104 · Cited by 169 · see citing works
WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud
Gros, J., Hu, J. K., Vinegoni, C., Feruglio, P. F., Weissleder, R., & Tabin, C. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.09.063 · Cited by 168 · see citing works
Conduit, P. T., & Raff, J. W. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.055 · Cited by 164 · see citing works
Mechanisms of elongation in embryogenesis
Keller, R. E. (2006) · Development · doi:10.1242/dev.02406 · Cited by 164 · see citing works
Cabernard, C., & Doe, C. Q. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.009 · Cited by 161 · see citing works
NuMA after 30 years: the matrix revisited
Radulescu, A. E., & Cleveland, D. W. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.003 · Cited by 160 · see citing works
Mechanisms of procentriole formation
Strnad, P., & Gönczy, P. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.06.004 · Cited by 159 · see citing works
Peyre, E., Jaouen, F., Saadaoui, M., Haren, L., Merdes, A., Durbec, P. L., & Morin, X. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201101039 · Cited by 157 · see citing works
Self-citationRobust control of mitotic spindle orientation in the developing epidermis
Poulson, N. D., & Lechler, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201008001 · Cited by 154 · see citing works
Manil-Ségalen, M., Johnston, C. A., Martin, C. A., Dumortier, J. G., Prehoda, K. E., David, N. B., Doe, C. Q., & Bellaı̈che, Y. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.004 · Cited by 149 · see citing works
Self-citationModulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed
Simon, M. A., Xu, A., Ishikawa, H., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.016 · Cited by 146 · see citing works
David, N. B., Martin, C. A., Manil-Ségalen, M., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1319 · Cited by 143 · see citing works
Kimura, A., & Onami, S. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.007 · Cited by 137 · see citing works
Kinetochore–microtubule interactions: steps towards bi‐orientation
Tanaka, T. U. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.294 · Cited by 135 · see citing works
Siller, K. H., Serr, M., Steward, R., Hays, T. S., & Doe, C. Q. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-04-0338 · Cited by 131 · see citing works
Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins
Hampoelz, B., Hoeller, O., Bowman, S., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1318 · Cited by 130 · see citing works
Wang, H., Ng, K. H., Qian, H., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1317 · Cited by 129 · see citing works
Mammalian Inscuteable Regulates Spindle Orientation and Cell Fate in the Developing Retina
Žigman, M., Cayouette, M., Charalambous, C., Schleiffer, A., Hoeller, O., Dunican, D. J., McCudden, C. R., Firnberg, N., Barres, B. A., Siderovski, D. P., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.030 · Cited by 128 · see citing works
Oriented cell motility and division underlie early limb bud morphogenesis
Wyngaarden, L. A., Vogeli, K. M., Ciruna, B. G., et al. (2010) · Development · doi:10.1242/dev.046987 · Cited by 126 · see citing works
Exploring the effects of mechanical feedback on epithelial topology
Aegerter‐Wilmsen, T., Smith, A. C., Christen, A. J., et al. (2010) · Development · doi:10.1242/dev.041731 · Cited by 122 · see citing works
Couwenbergs, C., Labbé, J., Goulding, M. Q., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200707085 · Cited by 120 · see citing works
Regulating neural proliferation in the Drosophila CNS
Sousa‐Nunes, R., Cheng, L. Y., & Gould, A. P. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.12.005 · Cited by 114 · see citing works
Bellaı̈che, Y., Massiani-Beaudoin, O., Stüttem, I., & Schweisguth, F. (2003) · Development · doi:10.1242/dev.00928 · Cited by 112 · see citing works
Self-citationHess, H. A., Röper, J.-C., Grill, S. W., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.025 · Cited by 110 · see citing works
Redemann, S., Pécréaux, J., Goehring, N. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012301 · Cited by 109 · see citing works
Das Problem der Befruchtung und der Isotropie des Eies, eine Theorie der Vererbung
Hertwig, O. (1884) · Cited by 105 · see citing works
Control of Embryonic Spindle Positioning and Gα Activity by C. elegans RIC-8
Couwenbergs, C., Spilker, A. C., & Gotta, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.059 · Cited by 105 · see citing works
Adherens junction domains are split by asymmetric division of embryonic neural stem cells
Marthiens, V., & ffrench‐Constant, C. (2009) · EMBO Reports · doi:10.1038/embor.2009.36 · Cited by 105 · see citing works
Park, D. H., & Rose, L. S. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.11.037 · Cited by 104 · see citing works
Januschke, J., & González, C. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200905024 · Cited by 101 · see citing works
Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts
Siller, K. H., & Doe, C. Q. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.018 · Cited by 98 · see citing works
Stereotypical Cell Division Orientation Controls Neural Rod Midline Formation in Zebrafish
Quesada-Hernández, E., Caneparo, L., Kaufmann, S., Winkler, S., Liebling, M., Fraser, S. E., & Heisenberg, C. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.009 · Cited by 97 · see citing works
Severson, A. F., & Bowerman, B. A. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210171 · Cited by 95 · see citing works
PAR Proteins Regulate Microtubule Dynamics at the Cell Cortex in C. elegans
Labbé, J.-C., Maddox, P. S., Salmon, E. D., & Goldstein, B. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00251-3 · Cited by 95 · see citing works
Speicher, S. A., Fischer, A., Knoblich, J. A., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.072 · Cited by 94 · see citing works
Asymmetric localization and function of cell-fate determinants: a fly’s view
Bardin, A. J., Borgne, R. L., & Schweisguth, F. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.12.002 · Cited by 90 · see citing works
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells
Gauthier-Fisher, A., Lin, D. C. C., Greeve, M. A., Kaplan, D. R., Rottapel, R. K., & Miller, F. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2339 · Cited by 90 · see citing works
Yu, F., Wang, H., Qian, H., et al. (2005) · Genes & Development · doi:10.1101/gad.1295505 · Cited by 89 · see citing works
The glial cell undergoes apoptosis in the microchaete lineage ofDrosophila
Fichelson, P., & Gho, M. (2002) · Development · doi:10.1242/dev.00198 · Cited by 84 · see citing works
Panbianco, C., Weinkove, D., Zanin, E., Jones, D., Divecha, N., Gotta, M., & Ahringer, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.06.002 · Cited by 79 · see citing works
Antagonistic Growth Regulation by Dpp and Fat Drives Uniform Cell Proliferation
Schwank, G., Tauriello, G., Yagi, R., Kranz, E., Koumoutsakos, P., & Basler, K. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.11.007 · Cited by 74 · see citing works
Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions
Žigman, M., Trinh, L. A., Fraser, S. E., & Moens, C. B. (2011) · Current Biology · doi:10.1016/j.cub.2010.12.005 · Cited by 71 · see citing works
Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex
O'Rourke, S. M., Christensen, S. N., & Bowerman, B. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2128 · Cited by 65 · see citing works
Determination of the Cleavage Plane in EarlyC. elegansEmbryos
Galli, M., & van den Heuvel, S. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090523 · Cited by 61 · see citing works
Jones, P. H., & Simons, B. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2292 · Cited by 57 · see citing works
Rebollo, E., Roldán, M., & González, C. (2009) · Development · doi:10.1242/dev.041822 · Cited by 52 · see citing works
Krueger, L. E., Wu, J.-C., Tsou, M.-F. B., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201001115 · Cited by 49 · see citing works
Growth and division—not a one-way road
Goranov, A. I., & Amon, A. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.06.004 · Cited by 40 · see citing works
Goulding, M. B., Canman, J. C., Senning, E. N., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703159 · Cited by 40 · see citing works
Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border inC. elegansembryos
Zhang, H., Skop, A. R., & White, J. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.015966 · Cited by 34 · see citing works
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Development and dynamics of cell polarity at a glance
Campanale, J. P., Sun, T. Y., & Montell, D. J. (2017) · Journal of Cell Science · doi:10.1242/jcs.188599 · Cited by 198 · see citing works
Epithelial junctions maintain tissue architecture by directing planar spindle orientation
Nakajima, Y.-I., Meyer, E. J., Kroesen, A., McKinney, S. A., & Gibson, M. C. (2013) · Nature · doi:10.1038/nature12335 · Cited by 204 · see citing works
Evolution of eumetazoan nervous systems: insights from cnidarians
Kelava, I., Rentzsch, F., & Technau, U. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0065 · Cited by 84 · see citing works
Godde, N. J., Sheridan, J. M., Smith, L. K., Pearson, H. B., Britt, K. L., Galea, R. C., Yates, L. L., Visvader, J. E., & Humbert, P. O. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004323 · Cited by 60 · see citing works
Asymmetric cell division during T cell development controls downstream fate
Pham, K., Shimoni, R., Charnley, M., Ludford-Menting, M. J., Hawkins, E. D., Ramsbottom, K., Oliaro, J., Izon, D., Ting, S. B., Reynolds, J., et al. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201502053 · Cited by 39 · see citing works
- Authors
- Morin, X., & Bellaïche, Y.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Morin, Xavier
- ORCID
- Morin, Xavier
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 21
- Issue
- 1
- Pages
- 102-119
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2008814168
- Cited by
- 423
- References
- 146
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 20 · 2023: 15 · 2022: 18 · 2021: 28 · 2020: 30 · 2019: 33 · 2018: 29 · 2017: 41 · 2016: 37 · 2015: 33 · 2014: 41 · 2013: 44 · 2012: 31
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- mitotic spindle orientation, asymmetric cell division, symmetric cell division, cell fate determination, tissue morphogenesis, tissue structure, animal development
- MeSH terms
- Animals, Cell Division, Cells, Spindle Apparatus, Developmental Biology, Cell Lineage
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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