Cited by 423Microtubule and mitosis dynamicsDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development

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Morin, Xavier, Bellaïche, Yohanns·2011·Developmental Cell

Abstract

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible implications in tissue morphogenesis. Many recent studies show that future advances in the field of mitotic spindle orientation will arise from combinations of physical perturbation and modeling with classical genetics and developmental biology approaches.

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Crossref · 10.1016/j.devcel.2011.06.012

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  • The different cell cycle characteristics of daughter cells are reminiscent of asymmetric cell fate in Drosophila and mammals.

    “a feature that is reminiscent of asymmetric cell fate in Drosophila and mammals [72].”

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Authors
Morin, X., & Bellaïche, Y.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Morin, Xavier
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2011-07
Volume
21
Issue
1
Pages
102-119
ISSN
1534-5807 (ISSN-L)
OpenAlex
W2008814168
Cited by
423
References
146
Citations by year
2026: 5 · 2025: 13 · 2024: 20 · 2023: 15 · 2022: 18 · 2021: 28 · 2020: 30 · 2019: 33 · 2018: 29 · 2017: 41 · 2016: 37 · 2015: 33 · 2014: 41 · 2013: 44 · 2012: 31
FWCI
3.30
Type
journal article
Language
en
Open access
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
mitotic spindle orientation, asymmetric cell division, symmetric cell division, cell fate determination, tissue morphogenesis, tissue structure, animal development
MeSH terms
Animals, Cell Division, Cells, Spindle Apparatus, Developmental Biology, Cell Lineage

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