The Drosophila blood-brain barrier: development and function of a glial endothelium
Open accessAbstract
The efficacy of neuronal function requires a well-balanced extracellular ion homeostasis and a steady supply with nutrients and metabolites. Therefore, all organisms equipped with a complex nervous system developed a so-called blood-brain barrier, protecting it from an uncontrolled entry of solutes, metabolites or pathogens. In higher vertebrates, this diffusion barrier is established by polarized endothelial cells that form extensive tight junctions, whereas in lower vertebrates and invertebrates the blood-brain barrier is exclusively formed by glial cells. Here, we review the development and function of the glial blood-brain barrier of Drosophila melanogaster. In the Drosophila nervous system, at least seven morphologically distinct glial cell classes can be distinguished. Two of these glial classes form the blood-brain barrier. Perineurial glial cells participate in nutrient uptake and establish a first diffusion barrier. The subperineurial glial (SPG) cells form septate junctions, which block paracellular diffusion and thus seal the nervous system from the hemolymph. We summarize the molecular basis of septate junction formation and address the different transport systems expressed by the blood-brain barrier forming glial cells.
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Drosophila has an evolutionarily conserved blood-brain barrier (BBB).
“Although Drosophila has an evolutionarily conserved blood-brain barrier (BBB), treatment with both cpds suppressed mitochondrial aggregates of larval dopaminergic neurons caused by PINK1 inactivation, suggesting that these drugs go through at least the Drosophila BBB (Figures 5C–5E) (Davis et al., 2019, Hindle et al., 2017, Limmer et al., 2014, Mayer et al., 2009, Zhang et al., 2018).”
From A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling (2020) · cites this paper as Limmer et al., 2014
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Flagged first, then by citations
Research works printed but not linked: 1
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Liu, L., MacKenzie, K. R., Putluri, N., Maletić-Savatić, M., & Bellen, H. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.024 · Cited by 556 · see citing works
A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord
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Coupled sensing of hunger and thirst signals balances sugar and water consumption
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Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila
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A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling
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- Authors
- Limmer, S., Weiler, A., Volkenhoff, A., Babatz, F., & Klämbt, C.
- Affiliations
- University of Münster (DE)
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-11-14
- Volume
- 8
- Pages
- 365-365
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4231875
- OpenAlex
- W2002425839
- Cited by
- 214
- References
- 179
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 20 · 2023: 25 · 2022: 22 · 2021: 26 · 2020: 23 · 2019: 16 · 2018: 25 · 2017: 14 · 2016: 7 · 2015: 8
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 1009)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- blood-brain barrier, Drosophila melanogaster, septate junctions, tight junctions, nutrient uptake, ion homeostasis, hemolymph, glial development, solute transport
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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