The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Cellular Decision Making and Biological Noise: From Microbes to Mammals
Open accessAbstract
Cellular decision-making is the process wherein cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell-fate decisions generate non-genetic cellular diversity, which may be critical for metazoan development as well as optimized microbial resource utilization and survival in a fluctuating, frequently stressful environment. Here we review several examples of cellular decision-making from viruses, bacteria, yeast, lower metazoans and mammals, highlighting the role of regulatory network structure and molecular noise. We propose that cellular decision-making is one of at least three key processes underlying development at various scales of biological organization.
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Synthetic biology to access and expand nature's chemical diversity
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Metadata
- Authors
- Balázsi, G., van Oudenaarden, A., & Collins, J. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 144
- Issue
- 6
- Pages
- 910-925
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2160803964
- Cited by
- 1,059
- References
- 16
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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