Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

Edlich, Frank, Banerjee, Soojay, Suzuki, Motoshi, Cleland, Megan M., Arnoult, Damien, Wang, Chunxin, Neutzner, Albert, Tjandra, Nico +1 more·2011·Cell

DOI 10.1016/j.cell.2011.02.034

Cited by (634)

Items 201–300 of 634

l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells
Ye Zhao, Qin Li Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang et al. · 2021 · Antioxidants
Bioactive lipids and the control of Bax pro-apoptotic activity
Vincent Mignard, Lisenn Lalier-Bretaudeau, François Paris, François M. Vallette · 2014 · Cell Death and Disease
Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
Michela Miani, Jenny Barthson, Máikel L. Colli, Flora Brozzi, Miriam Cnop, Decio Laks Eizirik · 2013 · Cell Death and Disease
The MUC1-C Oncoprotein Binds to the BH3 Domain of the Pro-apoptotic BAX Protein and Blocks BAX Function
Rehan Ahmad, Maroof Alam, Hasan N. Rajabi, Donald W. Kufe · 2012 · Journal of Biological Chemistry
Predisposition to Apoptosis in Hepatocellular Carcinoma: From Mechanistic Insights to Therapeutic Strategies
Jens Uwe Marquardt, Frank Edlich · 2019 · Frontiers in Oncology
Role of Mitofusins and Mitophagy in Life or Death Decisions
Mariana Joaquim, Mafalda Escobar‐Henriques · 2020 · Frontiers in Cell and Developmental Biology
Programmed cell death in plants: lessons from bacteria?
Junhui Wang, Kenneth W. Bayles · 2012 · Trends in Plant Science
Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid
Aisha Shamas‐Din, Dmitri Satsoura, O Khan, W Zhu, Brian F. Leber, Cécile Fradin, David William Andrews · 2014 · Cell Death and Disease
Allosteric sensitization of proapoptotic BAX
Jonathan R. Pritz, Franziska Wachter, Susan Lee, James Luccarelli, Thomas E. Wales, Daniel T. Cohen, Paul W. Coote, Gregory J. Heffron, John R. Engen, Walter W. Massefski et al. · 2017 · Nature Chemical Biology
Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells
Federico Lucantoni, Andreas Ulrich Lindner, Norma O’Donovan, Heiko Düßmann, Jochen H.M. Prehn · 2018 · Cell Death and Disease
Ensemble Properties of Bax Determine Its Function
Adeline Y. Robin, Sweta Iyer, Richard W. Birkinshaw, Jarrod John Sandow, Ahmad Z. Wardak, Cindy S. Luo, Melissa X. Shi, Andrew Ian Webb, Peter E. Czabotar, Ruth M. Kluck et al. · 2018 · Structure
Mitochondrial origins of fractional control in regulated cell death
LETÍCIA VITÓRIA DA SILVA SANTOS, ROBERT M. VOGEL, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo A. Stolovitzky, Pablo Meyer · 2019 · Nature Communications
Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death
Mitchell L. de Snoo, Erik Loewen Friesen, Yu Tong Zhang, Rebecca Earnshaw, Geneviève Dorval, Minesh Kapadia, Darren M. O’Hara, Victoria Agapova, Hien Chau, Ornella Pellerito et al. · 2019 · Cell Death and Disease
ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
Silvia Cristofanon, Simone Fulda · 2012 · Cell Death and Disease
Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways
Aisha Siddiqi, Syed Kazim Hasan, Sana Nafees, Summya Rashid, Bano Saidullah, Sarwat Sultana · 2015 · Experimental and Molecular Pathology
Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling
Tim Sen Wang, Isabelle Coppens, Anna Saorin, Nathan Ryan Brady, Anne Hamacher‐Brady · 2020 · Developmental Cell
The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function
Davia Blake, Kristen W. Lynch · 2021 · Immunological Reviews
Synergistic induction of apoptosis in A549 cells by dihydroartemisinin and gemcitabine
Chubiao Zhao, Weijie Gao, Tongsheng Chen · 2013 · APOPTOSIS
Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
Sweta Iyer, Rachel T. Uren, Michael A. Dengler, Melissa X. Shi, Etsuko Uno, Jerry M. Adams, Grant Dewson, Ruth M. Kluck · 2020 · Cell Death and Disease
The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy
Jan Ježek, Katrina F. Cooper, Randy Strich · 2021 · Biology
The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells?
Kuang-Qi Chen, Banghong Wei, Shuang-Li Hao, Wan-Xi Yang · 2022 · PubMed
Overview of BCL-2 Family Proteins and Therapeutic Potentials
Jason D. Huska, Heather M. Lamb, J. Marie Hardwick · 2018 · Methods in molecular biology
BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians
Consuelo Borrás, Cristina Mas‐Bargues, Aurora Román-Domínguez, Jorge Sanz‐Ros, Lucía Gimeno-Mallench, Marta Inglés, Juan Gambini, José Viña · 2020 · International Journal of Molecular Sciences
New limits of sensitivity of site-directed spin labeling electron paramagnetic resonance for membrane proteins
Enrica Bordignon, Stephanie Bleicken · 2017 · Biochimica et Biophysica Acta (BBA) - Biomembranes
BAX-Depleted Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage
Ryan Donahue, Margaret E. Maes, Joshua A. Grosser, Robert W. Nickells · 2019 · Molecular Neurobiology
Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax
Christian Bogner, Justin Kale, Justin P. Pogmore, Xiaoke Chi, Aisha Shamas‐Din, Cécile Fradin, Brian F. Leber, David William Andrews · 2020 · Molecular Cell
Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak
Collins Waguia Kontchou, Ian Edward Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich, Georg Alexander Häcker · 2022 · Cell Death and Differentiation
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis
Keke Guo, Run Liu, Rongrong Jing, Lusheng Wang, Xuenan Li, Kaini Zhang, Mengli Fu, Jiabin Ye, Zhenlin Hu, Wengang Zhao et al. · 2022 · Frontiers in Pharmacology
Stoichiometry and regulation network of Bcl-2 family complexes quantified by live-cell FRET assay
Fangfang Yang, Wenfeng Qu, Mengyan Du, Zihao Mai, Bin Wang, Yunyun Ma, Xiaoping Wang, Tongsheng Chen · 2019 · Cellular and Molecular Life Sciences
Mitochondrial Determinants of Anti-Cancer Drug-Induced Cardiotoxicity
Carmine Rocca, Ernestina Marianna De Francesco, Teresa Pasqua, Maria Concetta Granieri, Anna De Bartolo, Maria Eugenia Gallo Cantafio, Maria Grazia Muoio, Massimo Gentile, Antonino Neri, Tommaso Angelone et al. · 2022 · Biomedicines
The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond
Giovanni Monaco, Tim Vervliet, Haidar Akl, Geert Bultynck · 2012 · Cellular and Molecular Life Sciences
BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove
Xiang Li, Iris K. L. Tan, Stephen B. Ma, Colin Hockings, Tobias Kratina, Michael A. Dengler, Amber E. Alsop, Ruth M. Kluck, Grant Dewson · 2017 · Proceedings of the National Academy of Sciences
Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation and polypharmacological strategies
Bing Liu, Divesh Bhatt, Zoltán N. Oltvai, Joel S. Greenberger, İvet Bahar · 2014 · Scientific Reports
Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis
Estefanía Lucendo, Mónica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Férnández, Ismael Mingarro, Mar Orzáez · 2020 · Proceedings of the National Academy of Sciences
The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage
Qi Tian, Sheng Liu, Shoumeng Han, Wei Zhang, Xian-Yao Qin, Junhui Chen, Chengli Liu, Yujia Guo, Mingchang Li · 2022 · Neural Regeneration Research
Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival
Nicolas Rosa, Femke Speelman-Rooms, Jan B. Parys, Geert Bultynck · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicine
Bo Chen, Kang Xie, Jianzhong Zhang, Liting Yang, Hongshu Zhou, Liyang Zhang, Renjun Peng · 2023 · APOPTOSIS
Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms
Ksenia S. Egorova, А. В. Кибардин, Alexandra V. Posvyatenko, Valentine P. Ananikov · 2024 · Chemical Reviews
Loss of BAX by miR-365 Promotes Cutaneous Squamous Cell Carcinoma Progression by Suppressing Apoptosis
Liang Zhou, Ruirui Gao, Yinghui Wang, Meijuan Zhou, Zhenhua Ding · 2017 · International Journal of Molecular Sciences
Norcantharidin inhibits proliferation and promotes apoptosis via c‐Met/Akt/ mTOR pathway in human osteosarcoma cells
Liangwei Mei, Wenhua Sang, Kai Cui, Yabin Zhang, Fuchun Chen, Xiaochun Li · 2018 · Cancer Science
Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737
Thibaud T. Renault, Óscar Teijido, Florent Missire, Yogesh Tengarai Ganesan, Gisèle Velours, Hubert Arokium, Florian Beaumatin, Raul Llanos, Axel Athané, Nadine M. Camougrand et al. · 2015 · The International Journal of Biochemistry & Cell Biology
The Incomplete Puzzle of the BCL2 Proteins
Flores-Romero, Hector, García-Sáez, Ana J. · 2019 · Cells
Drp 1 is dispensable for apoptotic cytochrome c release in primed MCF 10 A and fibroblast cells but affects Bcl ‐2 antagonist‐induced respiratory changes
Pascaline Clerc, Shealinna X. Ge, Hongik Hwang, Jaylyn Waddell, Brian A. Roelofs, Mariusz Karbowski, Hiromi Sesaki, Brian M. Polster · 2013 · British Journal of Pharmacology
cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities
Stephanie Bleicken, Goetz Hofhaus, Begoña Ugarte‐Uribe, Rasmus R. Schröder, Ana J. García‐Sáez · 2016 · Cell Death and Disease
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance
Chaoyun Pan, Lingtao Jin, Xu Wang, Yuancheng Li, Jaemoo Chun, Austin C. Boese, Dan Li, Hee‐Bum Kang, Guojing Zhang, Lu Zhou et al. · 2019 · Journal of Clinical Investigation
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization
Daniel Luzon Morris, David W. Kastner, Sabrina Johnson, Marie‐Paule Strub, Yi He, Christopher K. E. Bleck, Duck‐Yeon Lee, Nico Tjandra · 2019 · Journal of Biological Chemistry
Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax
Eun Mi Kim, Jongdoo Kim, Jong Kuk Park, Sang‐Gu Hwang, Wun‐Jae Kim, Won‐Jae Lee, Sang Won Kang, Hong‐Duck Um · 2012 · Cellular Signalling
Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
Wen-jian Liu, Yibo Yin, Jingyi Sun, Sai Feng, Jin‐Kui Ma, Xiaoyan Fu, Ya‐Jun Hou, Mingfeng Yang, Bao‐liang Sun, Cundong Fan · 2018 · OncoTargets and Therapy
Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment
Jan Jezek, Kai‐Ti Chang, Amogh M. Joshi, Randy Strich · 2019 · EMBO Reports
Parkin promotes proteasomal degradation of misregulated BAX
Zeynep Cakir, Kathrin Funk, Joachim Lauterwasser, Franziska Todt, Ralf M. Zerbes, Aline Oelgeklaus, Atsushi Tanaka, Martin van der Laan, Frank Edlich · 2017 · Journal of Cell Science
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins
Zewei Ma, Dong-xiang Liu · 2017 · Acta Pharmacologica Sinica
Cellular apoptosis and necrosis as therapeutic targets for novel Eugenol Tosylate Congeners against Candida albicans
Shabir Ahmad Lone, Mohmmad Younus Wani, Pascaline Fru, Aijaz Ahmad · 2020 · Scientific Reports
An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane
Fujiao Lv, Fei Qi, Zhi Zhang, Maorong Wen, Justin Kale, Alessandro Piai, Lingyu Du, Shuqing Wang, Liujuan Zhou, Yaqing Yang et al. · 2021 · The EMBO Journal
The interactions between CdSe quantum dots and yeast Saccharomyces cerevisiae: Adhesion of quantum dots to the cell surface and the protection effect of ZnS shell
Jie Mei, Liyun Yang, Lu Lai, Ziqiang Xu, Can Wang, Jie Zhao, Jian-Cheng Jin, Feng‐Lei Jiang, Yi Liu · 2014 · Chemosphere
Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate
Marta N. Bogdał, Beata Hat, Marek Kochańczyk, Tomasz Lipniacki · 2013 · BMC Systems Biology
From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine
Maximilian L. Würstle, Elisabeth Zink, Jochen H.M. Prehn, Markus Rehm · 2014 · Cell Death and Disease
Dynamic Interaction of cBid with Detergents, Liposomes and Mitochondria
Stephanie Bleicken, Ana J. García‐Sáez, Elena Conte, Enrica Bordignon · 2012 · PLoS ONE
Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting
Marjan Aghvami, Fatemeh Ebrahimi, Mohammad Hadi Zarei, Ahmad Salimi, Razieh Pourahmad Jaktaji, Jalal Pourahmad · 2018 · Europe PMC (PubMed Central)
Bcl‑2 family: Novel insight into individualized therapy for ovarian cancer (Review)
Jing Yuan, Hua Lan, Xiao‐Yan Jiang, Da Xing Zeng, Songshu Xiao · 2020 · International Journal of Molecular Medicine
Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases
Shu-Yuan Zhang, Juan Zhao, Zhen-Zhen Quan, Hui Li, H. Qing · 2022 · Frontiers in Neuroscience
Comparison of Membrane Insertion Pathways of the Apoptotic Regulator Bcl-xL and the Diphtheria Toxin Translocation Domain
Mauricio Vargas‐Uribe, Mykola V. Rodnin, Alexey S. Ladokhin · 2013 · Biochemistry
Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective
Valentina Sora, Elena Papaleo · 2022 · Frontiers in Molecular Biosciences
Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease
Bharti Yadav, Sharanjot Kaur, Anuradha Yadav, Harkomal Verma, Swastitapa Kar, Binit Kumar Sahu, Kumari Riya Pati, Bibekanada Sarkar, Monisha Dhiman, Anil Kumar Mantha · 2024 · Journal of Biochemical and Molecular Toxicology
Astragalus membranaceus and Panax notoginseng, the Novel Renoprotective Compound, Synergistically Protect against Podocyte Injury in Streptozotocin-Induced Diabetic Rats
Ruonan Zhai, Guihua Jian, Teng Chen, Ling Xie, Rui Xue, Chongting Gao, Niansong Wang, Youhua Xu, Dingkun Gui · 2019 · Journal of Diabetes Research
Bcl-xL inhibits PINK1/Parkin-dependent mitophagy by preventing mitochondrial Parkin accumulation
Yu Si, Mengyan Du, Ao Yin, Zihao Mai, Yong Wang, Mengxin Zhao, Xiaoping Wang, Tongsheng Chen · 2020 · The International Journal of Biochemistry & Cell Biology
Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease
Veronika Kotrasová, Barbora Keresztesová, Gabriela Ondrovičová, Jacob Bauer, Henrieta Havalová, Vladimír Pevala, Eva Kutějová, Nina Kunová · 2021 · Life
Catechin from green tea had the potential to decrease the chlorpyrifos induced oxidative stress in larval zebrafish (Danio rerio)
Yun Fu Zhao, Chanlin Fang, Cuiyuan Jin, Zhiwei Bao, Guiling Yang, Yuanxiang Jin · 2021 · Pesticide Biochemistry and Physiology
Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: A small-angle neutron scattering and fluorescence study
Dmitri Satsoura, Norbert Kučerka, Sanjeevan Shivakumar, Jeremy Pencer, Corrie Griffiths, Brian F. Leber, David William Andrews, John Katsaras, Cécile Fradin · 2011 · Biochimica et Biophysica Acta (BBA) - Biomembranes
The Role of Bcl-xL in Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia on Human Colon Cancer
Xinxin Song, Seog-Young Kim, Yong Jun Lee · 2012 · Molecular Cancer Research
Identification of Bax-Interacting Proteins in Oligodendrocyte Progenitors during Glutamate Excitotoxicity and Perinatal Hypoxia–Ischemia
Sopio Simonishvili, Mohit Raja Jain, Hong Li, Steven W. Levison, Teresa L. Wood · 2013 · ASN NEURO
Tannic Acid Induces the Mitochondrial Pathway of Apoptosis and S Phase Arrest in Porcine Intestinal IPEC-J2 Cells
Ji Wang, Haisi Xiao, Yuanyuan Zhu, Shuiping Liu, Zhihang Yuan, Jing Wu, Lixin Wen · 2019 · Toxins
Free Radical Medicine and Biology
Kusal Kanti Das, Swastika N. Das, Mallanagoud S. Biradar, Varaprasad Bobbarala, S. Subba Tata · 2019 · IntechOpen eBooks
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer
Nasim Ebrahimi, Sahar Parkhideh, Setare Samizade, Alireza Nasr Esfahani, Sahar Samsami, Elnaz Yazdani, Samaneh Adelian, Siavash Rahimian Chaleshtori, Kamal Shahamiri, Amirhossein Ahmadi et al. · 2022 · Cytokine & Growth Factor Reviews
Subcellular Preconditioning of Stem Cells: Mito-Cx43 Gene Targeting is Cytoprotective Via Shift of Mitochondrial Bak and Bcl-xL Balance
Gang Lü, Shujia Jiang, Muhammad Ashraf, Khawaja Husnain Haider · 2012 · Regenerative Medicine
Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members
Lidia Villanova, Silvia Careccia, Ruggero D. Maria, Micol Eleonora Fiori · 2018 · International Journal of Molecular Sciences
Norcantharidin Inhibits SK-N-SH Neuroblastoma Cell Growth by Induction of Autophagy and Apoptosis
Zeping Han, Baoxia Li, Juanjuan Wang, Xiangqiang Zhang, Zhenhua Li, Liting Dai, Mingrong Cao, Jianwei Jiang · 2016 · Technology in Cancer Research & Treatment
Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis
Margaret E. Maes, Cassandra L. Schlamp, Robert W. Nickells · 2017 · PLoS ONE
A lipid perspective on regulated cell death
Hector Flores‐Romero, Uris Ros, Ana J. García‐Sáez · 2019 · International review of cytology
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation
G. Sekar, Adedolapo M. Ojoawo, Tudor Moldoveanu · 2022 · Biochemical Society Transactions
Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation
Raed Shalaby, Arzoo Diwan, Hector Flores‐Romero, Vanessa Hertlein, Ana J. García‐Sáez · 2022 · Cell Death and Differentiation
Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.
Mohammad Reza Abedini, Nafiseh Erfanian, Habibollah Nazem, Sara Jamali, Reyhane Hoshyar · 2016 · PubMed Central
Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML
Frank Reichenbach, Cornelius Jakob Wiedenmann, Enrico Schalk, Diana Becker, Kathrin Funk, Peter Scholz-Kreisel, Franziska Todt, Denise Wolleschak, Konstanze Döhner, Jens Uwe Marquardt et al. · 2017 · Clinical Cancer Research
The apoptotic pore on mitochondria: are we breaking through or still stuck?
Christoph Borner, David William Andrews · 2014 · Cell Death and Differentiation
BH3 Mimetics in Hematologic Malignancies
Pavel Klener, Dana Sovilj, Nicol Renešová, Ladislav Anděra · 2021 · International Journal of Molecular Sciences
The molecular mosaic of regulated cell death in the cardiovascular system
Matthew D. Martens, Jason M. Karch, Joseph W. Gordon · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Treatment With Anticancer Agents Induces Dysregulation of Specific Wnt Signaling Pathways in Human Ovarian Luteinized Granulosa Cells In Vitro
Ana Maria Sanchez, Veronica Giorgione, Paola Viganò, Enrico Papaleo, Massimo Candiani, Giorgia Mangili, Paola Panina‐Bordignon · 2013 · Toxicological Sciences
Altered mitochondrial apoptotic pathway in placentas from undernourished rat gestations
Louiza Belkacemi, Mina Desai, D. Michael Nelson, Michael Glenn Ross · 2011 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol
King, Louise E., Rodriguez-Enriquez, Ricardo, Pedley, Robert, Mellor, Charlotte E. L., Wang, Pengbo, Zindy, Egor, White, Michael R. H., Brennan, Keith, Gilmore, Andrew P. · 2022 · Cell Death & Differentiation
Activation of mitochondria-mediated apoptotic pathway in tri-ortho-cresyl phosphate-induced delayed neuropathy
Chaoshuang Zou, Ruirui Kou, Yuan Gao, Keqin Xie, Fuyong Song · 2013 · Neurochemistry International
Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells In Vitro
Marianne El Khoury, Tony Haykal, Mohammad Hassan Hodroj, Sonia Abou Najem, Rita Sarkis, Robin I. Taleb, Sandra E. Rizk · 2020 · Cancers
Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers
Daniel Luzon Morris, Sabrina Johnson, Christopher K. E. Bleck, Duck‐Yeon Lee, Nico Tjandra · 2020 · Journal of Biological Chemistry
Pharmacological Targeting of Executioner Proteins: Controlling Life and Death
Justin P. Pogmore, David Uehling, David William Andrews · 2021 · Journal of Medicinal Chemistry
Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy
Mahmoud Izadi, Tayyiba Akbar Ali, Ehsan Pourkarimi · 2021 · International Journal of Molecular Sciences
Protective effect of Aplysin on hepatic injury in ethanol-treated rats
Na Ge, Hui Liang, Ying Liu, Aiguo Ma, Lei Han · 2013 · Food and Chemical Toxicology
Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance
Fumihiko Nakao, Kiyoko Setoguchi, Yuichiro Semba, Takuji Yamauchi, Jumpei Nogami, Kensuke Sasaki, Hiroshi Imanaga, Tatsuya Terasaki, Manaka Miyazaki, Shigeki Hirabayashi et al. · 2023 · Leukemia
Excitotoxicity and Oxidative Stress in Acute Stroke
Ramón Rama, Julio César García · 2016 · InTech eBooks
The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA
Alina Muenchow, Sandra Weller, Clemens Hinterleitner, Elke Malenke, Stefanie Bugl, Stefan Wirths, Martin Müller, Klaus Schulze‐Osthoff, Walter E. Aulitzky, Hans‐Georg Kopp et al. · 2020 · Cell Death and Disease
Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes
J. P. Jose Merlin, Anine Crous, Heidi Abrahamse · 2024 · International Journal of Molecular Sciences
Pharmacological effects, molecular mechanisms and strategies to improve bioavailability of curcumin in the treatment of neurodegenerative diseases
Gang Wang, Xueyuan Zhou, Xiaoyan Pang, Ke Ma, Lü Li, Yuexin Song, Dongxia Hou, Xiaohua Wang · 2025 · Frontiers in Pharmacology
Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance
Annika Hantusch, Kushal Kumar Das, Ana J. García‐Sáez, Thomas Brunner, Markus Rehm · 2018 · Cell Death and Disease