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Cited by 294

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

Open access
Matos, Joao, Blanco, Miguel G., Maslen, Sarah, Skehel, J. Mark, West, Stephen C.·2011·Cell
DOI 10.1016/j.cell.2011.08.032
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Abstract

SUMMARY The efficient and timely resolution of DNA recombination intermediates is essential for bipolar chromosome segregation. Here, we show that the specialized chromosome segregation patterns of meiosis and mitosis, which require the coordination of recombination with cell-cycle progression, are achieved by regulating the timing of activation of two crossover-promoting endonucleases. In yeast meiosis, Mus81-Mms4 and Yen1 are controlled by phosphorylation events that lead to their sequential activation. Mus81-Mms4 is hyperactivated by Cdc5-mediated phosphorylation in meiosis I, generating the crossovers necessary for chromosome segregation. Yen1 is also tightly regulated and is activated in meiosis II to resolve persistent Holliday junctions. In yeast and human mitotic cells, a similar regulatory network restrains these nuclease activities until mitosis, biasing the outcome of recombination toward non-crossover products while also ensuring the elimination of any persistent joint molecules. Mitotic regulation thereby facilitates chromosome segregation while limiting the potential for loss of heterozygosity and sister-chromatid exchanges.

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Metadata

Authors
Matos, J., Blanco, M. G., Maslen, S., Skehel, J. M., & West, S. C.
Venue
Cell
Publisher
Elsevier BV
Published
2011-09
Volume
147
Issue
1
Pages
158-172
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2011.08.032
OpenAlex
W2103972950
Cited by
294
References
45
FWCI
11.05
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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