Cited by 739DNA Repair MechanismsCancer-related Molecular PathwaysFungal and yeast genetics research

The control of DNA repair by the cell cycle

Hustedt, Nicole, Durocher, Daniel·2017·Nature Cell Biology

Abstract

The correct duplication and transmission of genetic material to daughter cells is the primary objective of the cell division cycle. DNA replication and chromosome segregation present both challenges and opportunities for DNA repair pathways that safeguard genetic information. As a consequence, there is a profound, two-way connection between DNA repair and cell cycle control. Here, we review how DNA repair processes, and DNA double-strand break repair in particular, are regulated during the cell cycle to optimize genomic integrity.

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Crossref · 10.1038/ncb3452

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149 of 149 references verified0 citation errors · 0 not checkable

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Authors
Hustedt, N., & Durocher, D.
Affiliations
Mount Sinai Hospital (CA)
Corresponding author
Durocher, Daniel
Venue
Nature Cell Biology
Published
2016-12-23
Volume
19
Issue
1
Pages
1-9
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2562446577
Cited by
738
References
149
Citations by year
2026: 50 · 2025: 67 · 2024: 73 · 2023: 77 · 2022: 76 · 2021: 89 · 2020: 102 · 2019: 91 · 2018: 68 · 2017: 45
FWCI
6.14
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
DNA repair, cell cycle regulation, DNA double-strand break repair, genome segregation, DNA replication, genome stability, DNA damage response
MeSH terms
Replisomes, Animals, Cell Cycle, Chromosomes, DNA-Directed DNA Polymerase, DNA Repair, Humans, Multienzyme Complexes, DNA Breaks, Double-Stranded, Homologous Recombination

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