The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling
Open accessAbstract
SUMMARY Transforming growth factor beta (TGF-β) signaling, mediated through the transcription factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here we report that Smad3 co-occupies the genome with cell-type-specific master transcription factors. Thus, Smad3 occupies the genome with Oct4 in embryonic stem (ES) cells, Myod1 in myotubes, and PU.1 in pro-B cells. We find that these master transcription factors are required for Smad3 occupancy and that TGF-β signaling largely affects the genes bound by the master transcription factors. Furthermore, we show that induction of Myod1 in non-muscle cells is sufficient to re-direct Smad3 to Myod1 sites. We conclude that cell-type-specific master transcription factors determine the genes bound by Smad2/3 and are thus responsible for orchestrating the cell-type-specific effects of TGF-β signaling.
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Cites
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Histone modifications at human enhancers reflect global cell-type-specific gene expression
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“…and regulate gene expression (Ptashne, 1988), and master transcription factors are required for establishment, maintenance, and even reprogramming of cell identity (Takahashi and Yamanaka, 2006; Feng et al., 2008; Lassar et al., 1986; Seale et al., 2008; Zhou et al., 2008; Graf and Enver, 2009).”
Mediator and cohesin connect gene expression and chromatin architecture
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Self-citationRegulation of B lymphocyte and macrophage development by graded expression of PU.1
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PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells
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Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
Super-enhancers in the control of cell identity and disease
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Self-citationTransforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
Transcription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227
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Metadata
- Authors
- Mullen, A. C., Orlando, D. A., Newman, J. J., Lovén, J., Kumar, R. M., Bilodeau, S., Reddy, J., Guenther, M. G., DeKoter, R. P., & Young, R. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 147
- Issue
- 3
- Pages
- 565-576
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2144578935
- Cited by
- 570
- References
- 10
- FWCI
- 19.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mullen, A. C., Orlando, D. A., Newman, J. J., Lovén, J., Kumar, R. M., Bilodeau, S., Reddy, J., Guenther, M. G., DeKoter, R. P., & Young, R. A. (2011). Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling. Cell. https://doi.org/10.1016/j.cell.2011.08.050
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
