The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity
Open accessAbstract
Summary Insulin resistance, tissue inflammation and adipose tissue dysfunction are features of obesity/Type 2 diabetes. Accordingly, we generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knock-out (AKO) mice to investigate the function of NCoR in adipocyte biology and glucose/insulin homeostasis. Despite increased obesity, glucose tolerance was improved in AKO mice, and euglycemic clamp studies demonstrated enhanced insulin sensitivity in liver, muscle and fat. Adipose tissue macrophage infiltration and inflammation were also decreased. PPARγ response genes were upregulated in adipose tissue from AKO mice and CDK5-mediated PPARγ ser-273 phosphorylation was reduced, creating a constitutively active PPARγ state. This identifies a novel function of NCoR as an adaptor protein which enhances the ability of CDK5 to associate with and phosphorylate PPARγ. The dominant function of adipocyte NCoR is to transrepress PPARγ and promote PPARγ ser-273 phosphorylation, such that NCoR deletion leads to adipogenesis, reduced inflammation, and enhanced systemic insulin sensitivity, phenocopying the TZD treated state.
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A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
Oh, D. Y., Walenta, E., Akiyama, T. E., Lagakos, W. S., Lackey, D., Pessentheiner, A. R., Sasik, R., Hah, N., Chi, T. J., Cox, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3614 · Cited by 391
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Metadata
- Authors
- Li, P., Fan, W., Xu, J., Lu, M., Yamamoto, H., Auwerx, J., Sears, D. D., Talukdar, S., Oh, D., Chen, A., Bandyopadhyay, G., Scadeng, M., Ofrecio, J. M., Nalbandian, S., & Olefsky, J. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 147
- Issue
- 4
- Pages
- 815-826
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2123774383
- Cited by
- 266
- References
- 14
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, P., Fan, W., Xu, J., Lu, M., Yamamoto, H., Auwerx, J., Sears, D. D., Talukdar, S., Oh, D., Chen, A., Bandyopadhyay, G., Scadeng, M., Ofrecio, J. M., Nalbandian, S., & Olefsky, J. M. (2011). Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity. Cell. https://doi.org/10.1016/j.cell.2011.09.050
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