The role of exercise and PGC1α in inflammation and chronic disease
Open accessAbstract
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
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Mice show greater improvements in acquisition and retention based learning in hippocampus-dependent tasks following long-term exercise rather than shorter regimes of exercise.
“Further work illustrates that mice show greater improvements in acquisition and retention based learning in hippocampus-dependent tasks following long-term exercise rather than shorter regimes of exercise (Handschin and Spiegelman, 2008; Parachikova et al., 2008; Ploeger et al., 2009).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Handschin and Spiegelman, 2008
The passage headed “Systemic effects of exercise and PGC-1α” (page unavailable in our copy) says exercise improves learning and memory, but explicitly frames that statement as clinical data. It does not report mouse performance on hippocampus-dependent acquisition or retention tasks, or compare long-term with shorter exercise regimens; the paper’s short- versus long-term comparison concerns skeletal-muscle adaptation. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThree systematic reviews concluded that exercise can improve outcomes of mobility and functional ability in frail older people.
“Three systematic reviews of home-based and group-based exercise interventions for frail older people concluded that exercise can improve outcomes of mobility and functional ability (121-123).”
From Frailty in elderly people (2013) · cites this paper as [122]
PGC-1α may play a pivotal role in organismal metabolic homeostasis as a coactivator of nuclear receptors.
“As the transcriptional co-activation of nuclear receptors involved in multiple aspects of metabolism, PGC-1α may play a pivotal role in organismal metabolic homeostasis [31].”
From PGC-1α in aging and anti-aging interventions (2009) · cites this paper as [31]
Fit younger and older adults have quicker biological stress recoveries than unfit adults.
“Previous studies have shown that fit younger and older adults have quicker biological stress recoveries than unfit adults (71–73).”
From Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter (2015) · cites this paper as [72]
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- Authors
- Handschin, C., & Spiegelman, B. M.
- Affiliations
- University of Zurich (CH)
- Harvard University (US)
- Venue
- Nature
- Published
- 2008-07-01
- Volume
- 454
- Issue
- 7203
- Pages
- 463-469
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2587487
- OpenAlex
- W2033234733
- Cited by
- 1,083
- References
- 81
- Citations by year
- 2026: 41 · 2025: 59 · 2024: 49 · 2023: 55 · 2022: 52 · 2021: 67 · 2020: 69 · 2019: 68 · 2018: 62 · 2017: 71 · 2016: 60 · 2015: 77 · 2014: 67 · 2013: 71 · 2012: 64
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK054477)
- National Center for Chronic Disease Prevention and Health Promotion
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- PGC-1α, physical activity, inflammation, chronic disease, muscle plasticity, transcriptional coactivator, muscle function, anti-inflammatory response
- MeSH terms
- Animals, Chronic Disease, Humans, Inflammation, Obesity, Transcription Factors, Exercise, Muscle, Skeletal
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