The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
Open accessAbstract
Summary Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24 and miR-629. Moreover, we show that once this circuit is activated, it maintains suppression of HNF4a and sustains oncogenesis. Systemic administration of miR-124, which modulates inflammatory signaling, prevents and suppresses hepatocellular carcinogenesis by inducing tumor-specific apoptosis without toxic side-effects. As we also show that this HNF4α circuit is perturbed in human hepatocellular carcinomas, our data raise the possibility that manipulation of this microRNA feedback-inflammatory loop has therapeutic potential for treating liver cancer.
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Self-citationLNA-mediated microRNA silencing in non-human primates
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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
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Cited by
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
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IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
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Self-citationInterleukin-6 and its receptors: a highly regulated and dynamic system
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Metadata
- Authors
- Hatziapostolou, M., Polytarchou, C., Aggelidou, E., Drakaki, A., Poultsides, G. A., Jaeger, S. A., Ogata, H., Karin, M., Struhl, K., Hadzopoulou-Cladaras, M., & Iliopoulos, D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 147
- Issue
- 6
- Pages
- 1233-1247
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2123218517
- Cited by
- 445
- References
- 9
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hatziapostolou, M., Polytarchou, C., Aggelidou, E., Drakaki, A., Poultsides, G. A., Jaeger, S. A., Ogata, H., Karin, M., Struhl, K., Hadzopoulou-Cladaras, M., & Iliopoulos, D. (2011). An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis. Cell. https://doi.org/10.1016/j.cell.2011.10.043
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