The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
Local Translation of Extranuclear Lamin B Promotes Axon Maintenance
Open accessAbstract
Local protein synthesis plays a key role in regulating stimulus-induced responses in dendrites and axons. Recent genome-wide studies have revealed that thousands of different transcripts reside in these distal neuronal compartments, but identifying those with functionally significant roles presents a challenge. We performed an unbiased screen to look for stimulus-induced, protein synthesis-dependent changes in the proteome of Xenopus retinal ganglion cell (RGC) axons. The intermediate filament protein lamin B2 (LB2), normally associated with the nuclear membrane, was identified as an unexpected major target. Axonal ribosome immunoprecipitation confirmed translation of lb2 mRNA in vivo. Inhibition of lb2 mRNA translation in axons in vivo does not affect guidance but causes axonal degeneration. Axonal LB2 associates with mitochondria, and LB2-deficient axons exhibit mitochondrial dysfunction and defects in axonal transport. Our results thus suggest that axonally synthesized lamin B plays a crucial role in axon maintenance by promoting mitochondrial function.
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“Indeed, translation of nuclear-encoded mitochondrial mRNAs commonly follows homeoprotein capture by dopaminergic neurons or retinal ganglion cell growth cones (Alvarez-Fischer et al., 2011; Stettler et al., 2012; Yoon et al., 2012).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Yoon et al., 2012
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1 retracted
RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Nikolaev, A., McLaughlin, T., O’Leary, D. D. M., & Tessier-Lavigne, M. (2009) · Nature · doi:10.1038/nature07767 · Cited by 992
RetractedMitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Normal Table of Xenopus Laevis (Daudin)
Nieuwkoop, P. D., & Faber, J. (1958) · Copeia · doi:10.2307/1439568 · Cited by 4,542
Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy
Wallace, D. C., Singh, G., Lott, M. T., Hodge, J. A., Schurr, T. G., Lezza, A. M. S., Elsas, L. J., & Nikoskelainen, E. K. (1988) · Science · doi:10.1126/science.3201231 · Cited by 2,440
Computational Method to Predict Mitochondrially Imported Proteins and their Targeting Sequences
Claros, M. G., & Vincens, P. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00779.x · Cited by 1,650
Protein detection using proximity-dependent DNA ligation assays
Fredriksson, S., Gullberg, M. T., Jarvius, J., Olsson, C., Pietras, K., Gustafsdottir, S., Östman, A., & Landegren, U. D. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-473 · Cited by 1,518
Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy
Sullivan, T. L., Escalante‐Alcalde, D., Bhatt, H., Anver, M. R., BHAT, N. K., Nagashima, K., Stewart, C. L., & Burke, B. E. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.913 · Cited by 1,197
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Mitochondrial fragmentation in neurodegeneration.
Knott, A. B., Perkins, G., Schwarzenbacher, R., & Bossy-Wetzel, E. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2417 · Cited by 1,002
Mitochondrial dysfunction as a cause of optic neuropathies
Carelli, V., Ross‐Cisneros, F. N., & Sadun, A. A. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2003.10.003 · Cited by 852
Campbell, D. S., & Holt, C. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00551-7 · Cited by 815
Self-citationA Lethal Defect of Mitochondrial and Peroxisomal Fission
Waterham, H. R., Koster, J., van Roermund, C. W. T., Mooyer, P. A. W., Wanders, R. J. A., & Leonard, J. V. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa064436 · Cited by 749
Diagnosis, natural history, and management of Charcot–Marie–Tooth disease
Pareyson, D., & Marchesi, C. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70110-3 · Cited by 622
Dynamic visualization of local protein synthesis in hippocampal neurons
Aakalu, G., Smith, W. B., Nguyen, N., Jiang, C., & Schuman, E. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00295-1 · Cited by 611
Morpholino Oligos: Making Sense of Antisense?
Heasman, J. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0565 · Cited by 533
Human laminopathies: nuclei gone genetically awry
Capell, B. C., & Collins, F. S. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1906 · Cited by 525
A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System
Sasaki, S., Shionoya, A., Ishida, M., Gambello, M. J., Yingling, J., Wynshaw-Boris, A. J., & Hirotsune, S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00146-x · Cited by 508
Krohne, G., & Benavente, R. (1986) · Experimental Cell Research · doi:10.1016/0014-4827(86)90421-0 · Cited by 483
Asymmetrical β-actin mRNA translation in growth cones mediates attractive turning to netrin-1
Leung, K.-M., van Horck, F. P., Lin, A. C., Allison, R., Standart, N., & Holt, C. E. (2006) · Nature Neuroscience · doi:10.1038/nn1775 · Cited by 478
Self-citationDahl, K. N., Kahn, S. M., Wilson, K. L., & Discher, D. E. (2004) · Journal of Cell Science · doi:10.1242/jcs.01357 · Cited by 440
Local translation of RhoA regulates growth cone collapse
Wu, K. Y., Hengst, U., Cox, L. J., Macosko, E. Z., Jeromin, A., Urquhart, E. R., & Jaffrey, S. R. (2005) · Nature · doi:10.1038/nature03885 · Cited by 423
Lamin B1 is required for mouse development and nuclear integrity
Vergnes, L., Péterfy, M., Bergo, M. O., Young, S. G., & Reue, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401424101 · Cited by 391
Axonal Protein Synthesis Provides a Mechanism for Localized Regulation at an Intermediate Target
Brittis, P. A., Lü, Q., & Flanagan, J. G. (2002) · Cell · doi:10.1016/s0092-8674(02)00813-9 · Cited by 381
Dechat, T., Adam, S. A., Taimen, P., Shimi, T., & Goldman, R. D. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000547 · Cited by 379
Gumy, L. F., Yeo, G. S. H., Tung, Y. L., Zivraj, K. H., Willis, D. E., Coppola, G., Lam, B., Twiss, J. L., Holt, C. E., & Fawcett, J. W. (2010) · RNA · doi:10.1261/rna.2386111 · Cited by 367
Self-citationYao, J., Sasaki, Y., Wen, Z., Bassell, G. J., & Zheng, J. Q. (2006) · Nature Neuroscience · doi:10.1038/nn1773 · Cited by 345
Dieterich, D. C., Lee, J. J., Link, A. J., Graumann, J., Tirrell, D. A., & Schuman, E. M. (2007) · Nature Protocols · doi:10.1038/nprot.2007.52 · Cited by 342
Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons
Taylor, A. M., Berchtold, N. C., Perreau, V. M., Tu, C. H., Jeon, N. L., & Cotman, C. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6130-08.2009 · Cited by 328
Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs
Zivraj, K. H., Tung, Y. C. L., Piper, M., Gumy, L., Fawcett, J. W., Yeo, G. S. H., & Holt, C. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1800-10.2010 · Cited by 315
Self-citationHarris, W. A., Holt, C. E., & Bonhoeffer, F. (1987) · Development · doi:10.1242/dev.101.1.123 · Cited by 303
Self-citationLamins: building blocks or regulators of gene expression?
Hutchison, C. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm950 · Cited by 292
Yoon, Y., Yoon, D., Lim, I. K., Yoon, S., Chung, H., Rojo, M., Malka, F., Jou, M., Martinou, J., & Yoon, G. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20753 · Cited by 275
Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival
Cox, L. J., Hengst, U., Gurskaya, N. G., Lukyanov, K. A., & Jaffrey, S. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1677 · Cited by 273
Signaling Mechanisms Underlying Slit2-Induced Collapse of Xenopus Retinal Growth Cones
Piper, M., Anderson, R. B., Dwivedy, A., Weinl, C., van Horck, F., Leung, K.-M., Cogill, E., & Holt, C. E. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.008 · Cited by 272
Self-citationAlteration of nuclear lamin organization inhibits RNA polymerase II–dependent transcription
Spann, T. P., Goldman, A. E., Wang, C., Huang, S., & Goldman, R. D. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112047 · Cited by 272
Lilley, K. S., Razzaq, A., & Dupree, P. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(01)00275-7 · Cited by 269
The transcription factor Engrailed-2 guides retinal axons
Brunet, I., Weinl, C., Piper, M., Trembleau, A., Volovitch, M., Harris, W. A., Prochiantz, A., & Holt, C. E. (2005) · Nature · doi:10.1038/nature04110 · Cited by 264
Self-citationNavigational errors made by growth cones without filopodia in the embryonic xenopus brain
Chien, C.-B., Rosenthal, D. E., Harris, W. A., & Holt, C. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90181-p · Cited by 261
Self-citationPolarization and orientation of retinal ganglion cells in vivo
Zolessi, F. R., Poggi, L., Wilkinson, C. J., Chien, C.-B., & Harris, W. A. (2006) · Neural Development · doi:10.1186/1749-8104-1-2 · Cited by 237
Holtz, D., Tanaka, R. A., Hartwig, J. H., & McKeon, F. (1989) · Cell · doi:10.1016/0092-8674(89)90753-8 · Cited by 228
Mitochondrial dysfunction in amyotrophic lateral sclerosis
Shi, P., Gál, J., Kwinter, D. M., Liu, X., & Zhu, H. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.012 · Cited by 213
Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm.
Loewinger, L., & McKeon, F. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03073.x · Cited by 209
Mann, F., Ray, S., Harris, W. A., & Holt, C. E. (2002) · Neuron · doi:10.1016/s0896-6273(02)00786-9 · Cited by 206
Self-citationE3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN
Drinjákovic, J., Jung, H., Campbell, D. S., Strochlic, L., Dwivedy, A., & Holt, C. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.017 · Cited by 204
Self-citationAxonal elongation triggered by stimulus-induced local translation of a polarity complex protein
Hengst, U., Deglincerti, A., Kim, H. J., Jeon, N. L., & Jaffrey, S. R. (2009) · Nature Cell Biology · doi:10.1038/ncb1916 · Cited by 190
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons
Andreassi, C., Zimmermann, C., Mitter, R., Fusco, S., Vita, S. D., Saiardi, A., & Riccio, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2486 · Cited by 186
Identification of acis-Acting Dendritic Targeting Element in MAP2 mRNAs
Blichenberg, A., Schwanke, B., Rehbein, M., Garner, C. C., Richter, D., & Kindler, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08818.1999 · Cited by 171
Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency
Coffinier, C., Chang, S. Y., Nobumori, C., Tu, Y., Farber, E., Toth, J. I., Fong, L. G., & Young, S. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908790107 · Cited by 167
Patterson, K. D., Molofsky, A. B., Robinson, C. M., Acosta, S., Cater, C., & Fischer, J. A. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0374 · Cited by 164
Axonal degeneration in multiple sclerosis: The mitochondrial hypothesis
Su, K., Banker, G. A., BOURDETTE, D. N., & Forte, M. A. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0060-3 · Cited by 157
Mitochondrial Disorders: Clinical and Genetic Features
Simon, D. K., & Johns, D. R. (1999) · Annual Review of Medicine · doi:10.1146/annurev.med.50.1.111 · Cited by 151
Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults
Alvarez-Fischer, D., Fuchs, J., Castagner, F., Stettler, O., Massiani-Beaudoin, O., Moya, K. L., Bouillot, C., Oertel, W. H., Lombès, A., Faigle, W., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2916 · Cited by 150
The lamin CxxM motif promotes nuclear membrane growth
Schild-Prüfert, K., Vogel, A., & Krohne, G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01532 · Cited by 121
A Systematic Characterization of Mitochondrial Proteome from Human T Leukemia Cells
Rezaul, K., Wu, L., Mayya, V., Hwang, S., & Han, D. C. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400115-mcp200 · Cited by 120
Does timing of axon outgrowth influence initial retinotectal topography in Xenopus?
Holt, C. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-04-01130.1984 · Cited by 118
Self-citationExtracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo
Wizenmann, A., Brunet, I., Lam, J. S. Y., Sonnier, L., Beurdeley, M., Zarbalis, K. S., Weisenhorn, D. M. V., Weinl, C., Dwivedy, A., Joliot, A., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.018 · Cited by 117
Self-citationRequirement for Nudel and dynein for assembly of the lamin B spindle matrix
Ma, L., Tsai, M.-Y., Wang, S., Lu, B., Chen, R., Yates, J. R., Zhu, X., & Zheng, Y. (2009) · Nature Cell Biology · doi:10.1038/ncb1832 · Cited by 113
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein
Liang, Y., Yu, W., Li, Y., Yang, Z., Yan, X., Huang, Q., & Zhu, X. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308058 · Cited by 112
Ikegami, K., & Koike, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.057 · Cited by 105
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons
Nguyen, M. D., Shu, T., Sanada, K., Larivière, R., Tseng, H.-C., Park, S. K., Julien, J., & Tsai, L. (2004) · Nature Cell Biology · doi:10.1038/ncb1139 · Cited by 96
Electroporation of cDNA/Morpholinos to targeted areas of embryonic CNS in Xenopus
Falk, J., Drinjákovic, J., Leung, K.-M., Dwivedy, A., Regan, A. G., Piper, M., & Holt, C. E. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-107 · Cited by 93
Self-citationRegulation of voltage- and ligand-gated currents in rat hippocampal progenitor cellsin vitro
Sah, D. W. Y., Ray, J., & Gage, F. H. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199701)32:1 · Cited by 89
Local synthesis of nuclear‐encoded mitochondrial proteins in the presynaptic nerve terminal
Gioio, A. E., Eyman, M., Zhang, H., Lavina, Z. S., Giuditta, A., & Kaplan, B. B. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1096 · Cited by 85
Taylor, S. W., Warnock, D. E., Glenn, G. M., Zhang, B., Fahy, E., Gaucher, S. P., Capaldi, R., Gibson, B. W., & Ghosh, S. S. (2002) · Journal of Proteome Research · doi:10.1021/pr025533g · Cited by 82
Regulation of axonal trafficking of cytochrome c oxidase IV mRNA
Aschrafi, A., Natera-Naranjo, O., Gioio, A. E., & Kaplan, B. B. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.01.009 · Cited by 72
Casasoli, M., Spadoni, S., Lilley, K. S., Cervone, F., Lorenzo, G. D., & Mattei, B. (2008) · PROTEOMICS · doi:10.1002/pmic.200700523 · Cited by 65
Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants
Busch, A., Kiel, T., Heupel, W.-M., Wehnert, M. S., & Hubner, S. E. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.05.003 · Cited by 60
The Cytoplasmic Domain of Xenopus NF-Protocadherin Interacts with TAF1/Set
Heggem, M. A., & Bradley, R. S. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00036-4 · Cited by 47
Mitochondrial Swelling Impairs the Transport of Organelles in Cerebellar Granule Neurons
Kaasik, A., Safiulina, D., Choubey, V., Kuum, M., Zharkovsky, A., & Veksler, V. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702295200 · Cited by 46
Nudel Promotes Axonal Lysosome Clearance and Endo‐lysosome Formation via Dynein‐Mediated Transport
Zhang, Q., Wang, F., Cao, J., Shen, Y., Huang, Q., Bao, L., & Zhu, X. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00945.x · Cited by 35
Jing, X., & Malicki, J. J. (2009) · Development · doi:10.1242/dev.037739 · Cited by 24
Toesca, A. (1992) · Cell Biology International Reports · doi:10.1016/s0309-1651(06)80110-4 · Cited by 5
Flagged first, then by citations
1 of the 74 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
- Campbell, D.S., and Holt, C.E. (2001). Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32, 1013–1026. · DOI
- Chien, C.B., Rosenthal, D.E., Harris, W.A., and Holt, C.E. (1993). Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain. Neuron 11, 237–251. · DOI
- Drinjakovic, J., Jung, H., Campbell, D.S., Strochlic, L., Dwivedy, A., and Holt, C.E. (2010). E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 65, 341–357. · DOI
- Falk, J., Drinjakovic, J., Leung, K.M., Dwivedy, A., Regan, A.G., Piper, M., and Holt, C.E. (2007). Electroporation of cDNA/morpholinos to targeted areas of embryonic CNS in Xenopus. BMC Dev. Biol. 7, 107. · DOI
- Heiman, M., Schaefer, A., Gong, S., Peterson, J.D., Day, M., Ramsey, K.E., Suárez-Fariñas, M., Schwarz, C., Stephan, D.A., Surmeier, D.J., et al. (2008). A translational profiling approach for the molecular characterization of CNS cell types. Cell 135, 738–748. · DOI · Paper page
- Holt, C.E. (1984). Does timing of axon outgrowth influence initial retinotectal topography in Xenopus? J. Neurosci. 4, 1130–1152. · DOI
- Piper, M., Anderson, R., Dwivedy, A., Weinl, C., van Horck, F., Leung, K.M., Cogill, E., and Holt, C. (2006). Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron 49, 215–228. · DOI
- Zolessi, F.R., Poggi, L., Wilkinson, C.J., Chien, C.B., and Harris, W.A. (2006). Polarization and orientation of retinal ganglion cells in vivo. Neural Dev. 1, 2. · DOI
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Metadata
- Authors
- Yoon, B. C., Jung, H., Dwivedy, A., O'Hare, C. M., Zivraj, K. H., & Holt, C. E.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Holt, Christine E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 148
- Issue
- 4
- Pages
- 752-764
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3314965
- OpenAlex
- W2089419574
- Cited by
- 263
- References
- 74
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 22 · 2021: 17 · 2020: 24 · 2019: 17 · 2018: 21 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 21 · 2013: 26 · 2012: 19
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Wellcome Trust (085314/Z/08/Z, 085314)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- lamin B2, axon maintenance, local protein synthesis, axonal translation, retinal ganglion cells, axonal degeneration, mitochondrial dysfunction, axonal transport, intermediate filaments, Xenopus, axon guidance
- MeSH terms
- Animals, Axons, Axonal Transport, Embryo, Nonmammalian, Mitochondria, Retinal Ganglion Cells, Protein Biosynthesis, Xenopus laevis, Lamin Type B
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