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Cited by 317

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling

Open access
Speese, Sean D., Ashley, James, Jokhi, Vahbiz, Nunnari, John, Barria, Romina, Li, Yihang, Ataman, Bulent, Koon, Alex, Chang, Young-Tae, Li, Qian, Moore, Melissa J., Budnik, Vivian·2012·Cell
DOI 10.1016/j.cell.2012.03.032
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Abstract

SUMMARY We report a novel mechanism of ribonucleoprotein (RNP) nucleocytoplasmic export by nuclear envelope budding. During development of Drosophila synapses, a fragment of the Wnt-1 receptor, DFrizzled2, is imported into postsynaptic nuclei where it forms prominent foci. We now show these foci to be composed of large RNP granules harboring synaptic protein transcripts. These RNPs exit the nucleus via a budding mechanism akin to nuclear egress of Herpes-type viruses, a process previously thought to be exclusive to these viruses. During this mechanism, RNP granules bud into the space between the inner and the outer nuclear membranes (the perinuclear space), in a manner dependent on Lamin C, a nuclear protein linked to muscular dystrophies. Like herpes virus nuclear egress, this process requires protein kinase C, which is known to disrupt the lamin through phosphorylation. We suggest that nuclear budding is an endogenous nuclear export pathway for large RNP granules.

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Metadata

Authors
Speese, S. D., Ashley, J., Jokhi, V., Nunnari, J., Barria, R., Li, Y., Ataman, B., Koon, A., Chang, Y.-T., Li, Q., Moore, M. J., & Budnik, V.
Venue
Cell
Publisher
Elsevier BV
Published
2012-05
Volume
149
Issue
4
Pages
832-846
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2012.03.032
OpenAlex
W2070989134
Cited by
317
References
68
FWCI
15.22
Type
journal article
Language
en
Open access
bronze

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