Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Taipale, Mikko, Krykbaeva, Irina, Koeva, Martina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan·2012·Cell
Cited by (879)
Items 101–200 of 879
- Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90Sophie L. Mader, Abraham López, Jannis Lawatscheck, Qi Luo, Daniel Andreas Rutz, Ana P. Gámiz‐Hernández, Michael Sattler, Johannes Büchner, Ville R. I. Kaila · 2020 · Nature Communications
- Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using MonobodiesEmma J. Petrie, Richard W. Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M. Hildebrand, Sarah E. Garnish, Katherine A. Davies, Jarrod John Sandow, André L. Samson, Xavier J. Gavin et al. · 2020 · Proceedings of the National Academy of Sciences
- Comprehensive fitness maps of Hsp90 show widespread environmental dependenceFlynn, Julia M, Rossouw, Ammeret, Cote-Hammarlof, Pamela, Fragata, Inês, Mavor, David, Hollins, Carl, Bank, Claudia, Bolon, Daniel NA · 2020 · eLife
- HSP90: Enabler of Cancer AdaptationAlex M. Jaeger, Luke J. Whitesell · 2018 · Annual Review of Cancer Biology
- Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domainsBenjamin L. Piette, Nader Alerasool, Zhen‐Yuan Lin, Jessica Lacoste, Mandy Hiu Yi Lam, Wesley Wei Qian, Stephanie Tran, Brett G. Larsen, Eric I. Campos, Jian Peng et al. · 2021 · Molecular Cell
- Discovering cellular protein‐protein interactions: Technological strategies and opportunitiesKevin Titeca, Irma H. Lemmens, Jan H. Tavernier, Sven Eyckerman · 2018 · Mass Spectrometry Reviews
- Selective inhibition of the kinase DYRK1A by targeting its folding processIsao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato‐Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka et al. · 2016 · Nature Communications
- Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapyJana Franke, Simone Eichner, Carsten Zeilinger, Andreas Kirschning · 2013 · Natural Product Reports
- Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modulesAlina Röhl, Daniela Wengler, Tobias Madl, Stephan Lagleder, Franziska Tippel, Monika Herrmann, Jelle Hendrix, Klaus Richter, Gordon Hack, Andreas B. Schmid et al. · 2015 · Nature Communications
- Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer DevelopmentRayan Naser, Abdullah Aldehaiman, Escarlet Díaz‐Galicia, Stefan T. Arold · 2018 · Cancers
- Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37Dimitra Keramisanou, Adam A. Aboalroub, Ziming Zhang, Wenjun Liu, Devon Marshall, Andrea Diviney, Randy W. Larsen, Ralf Landgraf, Ioannis Gelis · 2016 · Molecular Cell
- HSP90: a promising broad-spectrum antiviral drug targetYiliang Wang, Fujun Jin, Rongze Wang, Feng Li, Yanting Wu, Kaio Kitazato, Yifei Wang · 2017 · Archives of Virology
- Vasculogenic Mimicry in Breast Cancer: Clinical Relevance and DriversGabriela Morales-Guadarrama, Rocio Garcı́a-Becerra, Edgar Armando Méndez-Pérez, Janice García‐Quiroz, Euclides Avila, Lorenza Dı́az · 2021 · Cells
- HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of TumorigenesisZarema Albakova, Yana Mangasarova, Akhmet Albakov, Liliya Gamilevna Gorenkova · 2022 · Frontiers in Oncology
- Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionParul Mishra, Julia M. Flynn, Tyler N. Starr, Daniel N. A. Bolon · 2016 · Cell Reports
- Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome SystemZu‐Guo Zheng, Xin Zhang, Xiao-Xiao Liu, Xiuxiu Jin, Lunzhi Dai, Huimin Cheng, Dan Jing, Pyone Myat Thu, Mu Zhang, Hongyang Li et al. · 2019 · Theranostics
- Molecular mechanisms in multiple myeloma drug resistanceNicholas Nikesitch, Silvia Ling · 2015 · Journal of Clinical Pathology
- 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer’s Disease MiceYe Ji Jeong, Ga-Young Kang, Jong Kwon, Hyung‐Do Choi, Jeong‐Ki Pack, Nam Kim, Yun‐Sil Lee, Hae‐June Lee · 2015 · Current Alzheimer Research
- Fidelity of Cotranslational Protein Targeting by the Signal Recognition ParticleXin Zhang, Shu‐ou Shan · 2014 · Annual Review of Biophysics
- Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90Edgar E. Boczek, Lasse G. Reefschläger, Marco Dehling, Tobias J. Struller, Elisabeth Häusler, Andreas Seidl, Ville R. I. Kaila, Johannes Büchner · 2015 · Proceedings of the National Academy of Sciences
- Natural heat shock protein 90 inhibitors in cancer and inflammationThadeu Estevam Moreira Maramaldo Costa, Nulgumnalli Manjunathaiah Raghavendra, Carmen Penido · 2020 · European Journal of Medicinal Chemistry
- Cullin-RING Ligase 5: Functional characterization and its role in human cancersYongchao Zhao, Xiufang Xiong, Yi Sun · 2020 · Seminars in Cancer Biology
- Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating ProteinYen-Chou Kuan, Tsutomu Hashidume, Takahiro Shibata, Kôji Uchida, Makoto Shimizu, Jun Inoue, Ryuichiro Sato · 2016 · Journal of Biological Chemistry
- Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed LigandsGerolamo Vettoretti, Elisabetta Moroni, Sara Sattin, Jiahui Tao, David A. Agard, Anna Bernardi, Giorgio Colombo · 2016 · Scientific Reports
- Proteome-wide identification of HSP70/HSC70 chaperone clients in human cellsSeung Woo Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji‐Hoon Lee, Carlos Tadeu Pagani Zanini, Antony Harvey, Jon M. Huibregtse, Peter J. Mueller et al. · 2020 · PLoS Biology
- Imbalances in the Hsp90 Chaperone Machinery: Implications for TauopathiesLindsey B. Shelton, John Koren, Laura J. Blair · 2017 · Frontiers in Neuroscience
- A molecular mechanism of chaperone-client recognitionLichun He, Timothy Sharpe, Adam Mazur, Sebastian Hiller · 2016 · Science Advances
- A Bacterial Effector Mimics a Host HSP90 Client to Undermine ImmunityVictor A. Lopez, Brenden C. Park, Dominika Nowak, Anju Sreelatha, Patrycja Zembek, Jessie Fernandez, Kelly A. Servage, Marcin Gradowski, Jacek Hennig, Diana R. Tomchick et al. · 2019 · Cell
- Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancerLei Wang, Qiuyue Zhang, Qidong You · 2021 · Medicinal Research Reviews
- A central chaperone-like role for 14-3-3 proteins in human cellsDmitri Segal, Stefan Maier, Giovanni J. Mastromarco, Wesley Wei Qian, Syed Nabeel‐Shah, Hyunmin Lee, Gaelen Moore, Jessica Lacoste, Brett G. Larsen, Zhen‐Yuan Lin et al. · 2023 · Molecular Cell
- Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machineryTing Li, Hu‐Lin Jiang, Yunguang Tong, Jin‐Jian Lu · 2018 · Journal of Hematology & Oncology
- Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational RelevanceJian Zhang, Houde Li, Yu Liu, Kejia Zhao, Shiyou Wei, Eric T. Sugarman, Lunxu Liu, Gao Zhang · 2022 · Cells
- Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptorNoddings, Chari M., Johnson, Jill L., Agard, David A. · 2023 · Nature Structural & Molecular Biology
- Functional principles and regulation of molecular chaperonesVinay Dahiya, Johannes Büchner · 2018 · Advances in protein chemistry and structural biology
- Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degradersXuewei Wu, Xiaobao Yang, Yan Xiong, Ruitong Li, Takahiro Ito, Tamer A. Ahmed, Zoi Karoulia, Christos Adamopoulos, Hong Wang, Li Wang et al. · 2021 · Nature Cancer
- Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signalingLaura Mediani, Francesco Antoniani, Veronica Galli, Jonathan Vinet, Arianna Dorotea Carrà, Ilaria Bigi, Vadreenath Tripathy, Tatiana Tiago, Marco Cimino, Giuseppina Leo et al. · 2021 · EMBO Reports
- Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expressionAlejandra G. Erlejman, Mariana Lagadari, Judith Toneatto, Graciela Piwien‐Pilipuk, Mario D. Galigniana · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formationWei Huang, Min Ye, Lianru Zhang, Qun-dan Wu, Min Zhang, Jianhua Xu, Wei Zheng · 2014 · Molecular Cancer
- Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein KinasesSharadha Dayalan Naidu, Calum D. Sutherland, Ying Wen Zhang, Ana Risco, Laureano de la Vega, Christopher James Caunt, C. James Hastie, Douglas J. Lamont, Laura Torrente, Sudhir Chowdhry et al. · 2016 · Molecular and Cellular Biology
- The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegenerationKaushik Bhattacharya, Didier Picard · 2021 · Cellular and Molecular Life Sciences
- Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulationSara García‐Alonso, Pablo Mesa, Laura de la Puente Ovejero, Gonzalo Aizpurua, Carmen G. Lechuga, Eduardo Zarzuela, Clara María Santiveri, Manuel Sanclemente, Javier Muñoz, Mónica Musteanu et al. · 2022 · Molecular Cell
- Advances in the structures, mechanisms and targeting of molecular chaperonesJinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang · 2025 · Signal Transduction and Targeted Therapy
- The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retrovirusesBarbara Hummel, Erik C Hansen, Aneliya Yoveva, Fernando Aprile-Garcia, Rebecca Hussong, Ritwick Sawarkar · 2017 · Nature Structural & Molecular Biology
- Physical and functional interactome atlas of human receptor tyrosine kinasesKari Salokas, Tiina Öhman, Xiaonan Liu, Iftekhar Mahmud Chowdhury, Lisa M. Gawriyski, Salla Keskitalo, Markku T Varjosalo · 2022 · EMBO Reports
- Hsp90 chaperones PPARγ and regulates differentiation and survival of 3T3-L1 adipocytesMinh Tú Nguyễn, Péter Csermely, Csaba Sőti · 2013 · Cell Death and Differentiation
- Reversible phosphorylation of the 26S proteasomeXing Guo, Xiuliang Huang, Jinan Chen · 2017 · Protein & Cell
- Proteotoxic Stress and Cell Death in Cancer CellsClaudio Brancolini, Luca Iuliano · 2020 · Cancers
- Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregationRon Geller, Sebastian Pechmann, Ashley Acevedo, Raul Andino, Judith Frydman · 2018 · Nature Communications
- Small-Molecule Kinase DownregulatorsLyn H. Jones · 2017 · Cell chemical biology
- Targeted Protein Degradation Induced by HEMTACs Based on HSP90Zhenzhen Li, Siyue Ma, Ling Zhang, Shuxin Zhang, Zhao Ma, Lüpei Du, Minyong Li · 2022 · Journal of Medicinal Chemistry
- Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung CancerTim N. Beck, Vlad A. Korben, Alexander E. Kudinov, Rachel Georgopoulos, Nehal Solanki-Patel, Magda Andrews-Hoke, Timothy M. Kistner, David Pépin, Patricia K. Donahoe, Émmanuelle Nicolas et al. · 2016 · Cell Reports
- HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L PolymerasesLouis-Marie Bloyet, Jérémy Welsch, François Enchéry, Cyrille Mathieu, Sylvain de Breyne, Branka Horvat, Boyan Grigorov, Denis Gerlier · 2016 · Journal of Virology
- Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitorsKristin E. Beebe, Mehdi Mollapour, Bradley T. Scroggins, Chrisostomos Prodromou, Wanping Xu, Mari Tokita, Tony Taldone, Lester Pullen, Bettina K. Zierer, Min-Jung Lee et al. · 2013 · Oncotarget
- Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant GliomasAlessandro Canella, Alessandra M. Welker, Ji Young Yoo, Jihong Xu, Fazly Salleh Abas, Divya Kesanakurti, Prabakaran Nagarajan, Christine E. Beattie, Erik P. Sulman, Joseph Liu et al. · 2017 · Clinical Cancer Research
- Pervasive mislocalization of pathogenic coding variants underlying human disordersJessica Lacoste, Marzieh Haghighi, Shahan Haider, Chloe Reno, Zhen‐Yuan Lin, Dmitri Segal, Wesley Wei Qian, Xueting Xiong, Tanisha Teelucksingh, Esteban Alberto Miglietta et al. · 2024 · Cell
- Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric LigandsSara Sattin, Jiahui Tao, Gerolamo Vettoretti, Elisabetta Moroni, Marzia Pennati, Alessia Lopergolo, Laura Morelli, Antonella Bugatti, Abbey D. Zuehlke, Mike Moses et al. · 2015 · Chemistry - A European Journal
- Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitorsAlireza Azimi, Stefano Caramuta, Brinton A. Seashore-Ludlow, Johan Boström, Jonathan L. Robinson, Fredrik Edfors, Rainer Tuominen, Kristel Kemper, Oscar Krijgsman, Daniel S. Peeper et al. · 2018 · Molecular Systems Biology
- Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1Kauko, Otto, Imanishi, Susumu Y., Kulesskiy, Evgeny, Yetukuri, Laxman, Laajala, Teemu Daniel, Sharma, Mukund, Pavic, Karolina, Aakula, Anna, Rupp, Christian, Jumppanen, Mikael et al. · 2020 · Journal of Biological Chemistry
- Phenotypic lentivirus screens to identify functional single domain antibodiesFlorian Ingo Schmidt, Leo Hanke, Benjamin M. Morin, R. Camille Brewer, Vesna Brusic, Sean P. J. Whelan, Hidde L. Ploegh · 2016 · Nature Microbiology
- HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylationJasmeen Oberoi, Xavier Aran-Guiu, Emily A. Outwin, Pascale Schellenberger, Theodoros I. Roumeliotis, Jyoti Sharma Choudhary, Laurence H. Pearl · 2022 · Nature Communications
- Signaling from RAS to RAF: The Molecules and Their MechanismsHyesung Jeon, Emre Tkacik, Michael J. Eck · 2024 · Annual Review of Biochemistry
- Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer CellsMorgan Campbell Hunter, Kyle Leonard O’Hagan, Amy Kenyon, Karim Colin Hassan Dhanani, Earl Prinsloo, Adrienne Lesley Edkins · 2014 · PLoS ONE
- Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90Alexandra Rehn, Elisabetta Moroni, Bettina K. Zierer, Franziska Tippel, Giulia Morra, Christine John, Klaus Richter, Giorgio Colombo, Johannes Büchner · 2016 · Journal of Molecular Biology
- In-cell identification and measurement of RNA-protein interactionsAntoine Graindorge, Inês Pinheiro, Anna Nawrocka, Allison C. Mallory, Peter Tsvetkov, Noa Gil, Carlo Carolis, Frank Buchholz, Igor Ulitsky, Édith Heard et al. · 2019 · Nature Communications
- Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex FormationHiroshi Katoh, Toru Kubota, Yuichiro Nakatsu, Maino Tahara, Minoru Kidokoro, Makoto Takeda · 2017 · Journal of Virology
- A global view of Hsp90 functionsGabriela Chiosis, Chad A. Dickey, Jill L. Johnson · 2013 · Nature Structural & Molecular Biology
- A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 SpeciesHongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric M. Sturgill, Sarah K. Brennan, Stefan O. Ochiana, Erica M. Gomes-DaGama, Siddhartha Sen, Anna Rodina et al. · 2015 · Cell Reports
- Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone SystemStephen T. Hallett, Martyna W. Pastok, Rhodri M. L. Morgan, Anita Wittner, Katie L. I. M. Blundell, Ildikó Felletár, Stephen R. Wedge, Chrisostomos Prodromou, Martin E. M. Noble, Laurence H. Pearl et al. · 2017 · Cell Reports
- The Hsp90 isoforms from S. cerevisiae differ in structure, function and client rangeHannah Girstmair, Franziska Tippel, Abraham López, Katarzyna M. Tych, Frank Stein, Per Haberkant, Philipp W. N. Schmid, Dominic Helm, Matthias Rief, Michael Sattler et al. · 2019 · Nature Communications
- DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1Hye-Youn Kim, Youngmi Kim, Suntaek Hong · 2021 · Cell Death and Disease
- HSP105 Recruits Protein Phosphatase 2A To Dephosphorylate β-CateninNancy Yu, Michael Kakunda, Victoria C. Pham, Jennie Rebecca Lill, Pan Du, Matthew J. Wongchenko, Yibing Yan, Ron Firestein, XiaoDong Huang · 2015 · Molecular and Cellular Biology
- The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and CancerMichael W. Hance, Krystal D. Nolan, Jennifer S. Isaacs · 2014 · Cancers
- Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90–Kinase InteractionsMeining Wang, Aijun Shen, Chi Zhang, Zilan Song, Jing Ai, Hong‐Chun Liu, Li‐Ping Sun, Jian Ding, Meiyu Geng, Ao Zhang · 2016 · Journal of Medicinal Chemistry
- Widespread remodeling of proteome solubility in response to different protein homeostasis stressesXiaojing Sui, Douglas E. V. Pires, Angelique R. Ormsby, Dezerae Cox, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David Benjamin Ascher, Gavin E. Reid, Danny M. Hatters · 2020 · Proceedings of the National Academy of Sciences
- The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor ModelsNaoto Miyajima, Shinji Tsutsumi, Carole Sourbier, Kristin E. Beebe, Mehdi Mollapour, Candy Rivas, Soichiro Yoshida, Jane B. Trepel, Ying Huang, Manabu Tatokoro et al. · 2013 · Cancer Research
- TYK2: An Upstream Kinase of STATs in CancerKatharina Wöss, Natalija Simonović, Birgit Strobl, Sabine Macho‐Maschler, Mathias M. Müller · 2019 · Cancers
- Targeting the LKB1 Tumor SuppressorRui–Xun Zhao, Zhi‐Xiang Xu · 2014 · Current Drug Targets
- C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of actionDavid Bickel, Holger Gohlke · 2019 · Bioorganic & Medicinal Chemistry
- The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myelomaMichael Heider, Ruth Eichner, Jacob Stroh, Volker Morath, Anna Kuisl, Jana Zecha, Jannis Lawatscheck, Kheewoong Baek, Anne-Kathrin Garz, Martina Rudelius et al. · 2021 · Molecular Cell
- The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathwaysXubo Chen, Xueyan Zhao, Hua “Linda” Cai, Haiying Sun, Yujuan Hu, Xiang Huang, Wen Kong, Weijia Kong · 2017 · Redox Biology
- Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric networkLopez, Abraham, Dahiya, Vinay, Delhommel, Florent, Freiburger, Lee, Stehle, Ralf, Asami, Sam, Rutz, Daniel, Blair, Laura, Buchner, Johannes, Sattler, Michael · 2021 · Science Advances
- Brassinosteroid nuclear signaling recruits HSP 90 activityDespina Samakovli, Theoni Margaritopoulou, Constantinos Prassinos, Dimitra Milioni, Polydefkis Hatzopoulos · 2014 · New Phytologist
- Stabilization of integrin‐linked kinase by the Hsp90‐CHIP axis impacts cellular force generation, migration and the fibrotic responseKorana Radovanac, Jessica Morgner, Jan-Niklas Schulz, Katrin Blumbach, Cam Patterson, Tamar Geiger, Matthias Mann, Thomas Krieg, Beate Eckes, Reinhard Fässler et al. · 2013 · The EMBO Journal
- Multifaceted roles of HEAT SHOCK PROTEIN 90 molecular chaperones in plant developmentTereza Tichá, Despina Samakovli, Anna Kuchařová, Tereza Vavrdová, Jozef Šamaj · 2020 · Journal of Experimental Botany
- Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycleBiebl, Maximilian M., Lopez, Abraham, Rehn, Alexandra, Freiburger, Lee, Lawatscheck, Jannis, Blank, Birgit, Sattler, Michael, Buchner, Johannes · 2021 · Nature Communications
- Genes without prominence: a reappraisal of the foundations of biologyArto Annila, Keith F. Baverstock · 2014 · Journal of The Royal Society Interface
- Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS -Mutant MelanomaHans Eirik Haarberg, Kim H.T. Paraiso, Elizabeth R. Wood, Vito W. Rebecca, Vernon K. Sondak, John M. Koomen, Keiran S.M. Smalley · 2013 · Molecular Cancer Therapeutics
- Tyrosine kinase 2 – Surveillant of tumours and bona fide oncogeneNicole R. Leitner, Agnieszka Witalisz‐Siepracka, Birgit Strobl, Mathias M. Müller · 2015 · Cytokine
- Regulation of the Hsp90 systemSiyuan Sima, Klaus Richter · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic trapsAmir Bitran, William M. Jacobs, Xiadi Zhai, Eugene I. Shakhnovich · 2020 · Proceedings of the National Academy of Sciences
- Hsp70-mediated quality control: should I stay or should I go?Verena Kohler, Claes Andréasson · 2020 · Biological Chemistry
- Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in miceTetsuro Marunouchi, Chiharu Nishiumi, Saki Iinuma, Emi Yano, Kouichi Tanonaka · 2021 · European Journal of Pharmacology
- Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicansCaplan, Tavia, Polvi, Elizabeth J., Xie, Jinglin L., Buckhalter, Shoshana, Leach, Michelle D., Robbins, Nicole, Cowen, Leah E. · 2018 · Cell Reports
- Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted MutantsThomas L. Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick H. Yim, Candy Rivas, Sylvia V. Alarcon, Harvey Schwartz, Kofi K. Khamit-Kush et al. · 2015 · PLoS ONE
- Evaluating Melanoma Drug Response and Therapeutic Escape with Quantitative ProteomicsVito W. Rebecca, Elizabeth R. Wood, Inna Smalley, Kim H.T. Paraiso, Hans Eirik Haarberg, Yi Chen, Yun Xiang, Amod A. Sarnaik, Geoffrey Thomas Gibney, Vernon K. Sondak et al. · 2014 · Molecular & Cellular Proteomics
- Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer CellsGiusy Tornillo, Catherine N. Knowlson, Howard D. Kendrick, Joe Cooke, Hasan Mirza, Iskander Aurrekoetxea-Rodríguez, María dM Vivanco, Niamh E. Buckley, Anita E. Grigoriadis, Matthew John Smalley · 2018 · Cell Reports
- Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client InteractionsAntonella Paladino, Mark R. Woodford, Sarah J. Backe, Rebecca Sager, Priyanka Kancherla, Michael Daneshvar, Victor Z. Chen, Dimitra Bourboulia, Elham F. Ahanin, Chrisostomos Prodromou et al. · 2020 · Chemistry - A European Journal
- Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase DegradationGnana Prakasam Krishnamoorthy, Teresa Guida, Luigi Alfano, Elvira Avilla, Massimo Mattia Santoro, Francesca Carlomagno, Rosa Marina Melillo · 2013 · Journal of Biological Chemistry
- E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cellsRahul S. Samant, Paul Andrew Clarke, Paul Workman · 2014 · Proceedings of the National Academy of Sciences
- DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interactionXiangling Chen, Peng Liu, Quanren Wang, Yun Li, Fu Li, Haoyu Fu, Jianming Zhu, Zhaoqiang Chen, Weiliang Zhu, Chengying Xie et al. · 2018 · Cancer Letters