Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Taipale, Mikko, Krykbaeva, Irina, Koeva, Martina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan·2012·Cell
DOI 10.1016/j.cell.2012.06.047

Cited by (879)

Items 701–800 of 879

  1. Antifungal Resistance in Candida albicans
    Sima Sadat Seyedjavadi, Farahnaz Hatami, Zahra Jahanshiri · 2024 · IntechOpen eBooks
  2. Allosteric Inhibitors of Hsp70: Drugging the Second Chaperone of Tumorigenesis
    Sharan R. Srinivasan, Hao Shao, Xiaokai Li, Jason E. Gestwicki · 2015 · Topics in medicinal chemistry
  3. Relative Specificity: All Substrates Are Not Created Equal
    Yan Zeng · 2014 · Genomics Proteomics & Bioinformatics
  4. Oxygen-independent, CDK4/CDK6-dependent degradation of hypoxia-inducible factor-1α takes cancers’ breath away
    Len Neckers · 2022 · Oncotarget
  5. Predictive value of CDC37 gene expression for targeted therapy in metastatic colorectal cancer
    Hiroyuki Arai, Yan Yang, Yasmine Baca, Joshua Millstein, Tadamichi Denda, Fang‐Shu Ou, Federico Innocenti, Hiroyuki Takeda, Yohei Kubota, Ayako Doi et al. · 2024 · European Journal of Cancer
  6. Huntingtin protein–protein interactions: From biology to therapeutic targets
    Eduardo Silva Ramos, Todd M. Greco, Ileana M. Cristea, Erich E. Wanker · 2024 · Elsevier eBooks
  7. A fluorescence‐based sensor for calibrated measurement of protein kinase stability in live cells
    Joseph West Paul, Serena Muratcioğlu, John Kuriyan · 2024 · Protein Science
  8. Cell biology: A key driver of therapeutic innovation
    Oliver D. Hantschel, Giulio Superti‐Furga · 2012 · The Journal of Cell Biology
  9. Acting on Folding Effectors to Improve Recombinant Protein Yields and Functional Quality
    Ario de Marco · 2017 · Methods in molecular biology
  10. The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
    Bertal Huseyin Aktas, Berin Upcin, Erik Henke, Manju Padmasekar, Xuebin Qin, Süleyman Ergün · 2019 · Stem Cells International
  11. A role for epigenetic adaption in evolution
    Ichiro Yahara · 2019 · Genes to Cells
  12. Cytosolic Heat Shock Protein 90 in Plant Hormone and Environmental Stress Response
    Kenji Yamada, Etsuko Watanabe · 2019 · Heat shock proteins
  13. Deciphering Network Crosstalk: The Current Status and Potential of miRNA Regulatory Networks on the HSP40 Molecular Chaperone Network
    Lion Budrass, Richard P. Fahlman, Sue‐Ann Mok · 2021 · Frontiers in Genetics
  14. Probing Single Chaperone Substrates
    Florian Wruck, Mario J. Avellaneda, Mohsin M. Naqvi, Eline J. Koers, Katharina Till, L. Gross, Fatemeh Moayed, A. Roland, Laurens W.H.J. Heling, Alireza Mashaghi et al. · 2023 · Royal Society of Chemistry eBooks
  15. Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target
    Ranu Pal, Dongwei Hui, Heather Menchen, Huiping Zhao, Olivier Mozziconacci, Heather Wilkins, Brian S. J. Blagg, Christian Schöneich, Russell Howard Swerdlow, Mary Lou Michaelis et al. · 2023 · Frontiers in Aging Neuroscience
  16. Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones
    Natasha Marie-Eraine Boel, Adrienne Lesley Edkins · 2018 · Springer eBooks
  17. Targeting the Hsp90/Aha1 Complex for the Treatment of Tauopathies
    Lindsey B. Shelton · 2018 · Digital Commons - University of South Florida (University of South Florida)
  18. PROactively TACkling CDK4/6 therapy resistance
    Signe Caksa, Andrew E. Aplin · 2021 · Nature Cancer
  19. The pharmacogenomic assessment of molecular epithelial-mesenchymal transition signatures reveals drug susceptibilities in cancer cell lines
    Alexander J. Ohnmacht, Göksu Avar, Marisa K. Schübel, Thomas J. O’Neill, Daniel Krappmann, Michael P. Menden · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Survivin Mediates Mitotic Onset in HeLa Cells Through Activation of the Cdk1-Cdc25B Axis
    Pedro M. Canovas · 2024 · Research Square
  21. The HSP90–CDC37 Chaperone System Orchestrates RAF1 Kinase Activation Through a Pre-Dimerization Mechanism
    Gonzalo Aizpurua, Pablo Mesa, Laura de la Puente Ovejero, J. Rafael Ciges-Tomas, Lucia Lomba-Riego, Carmen G. Lechuga, Eduardo Zarzuela, Marta Isasa, Leander van der Hoeven, Jesper.V. Olsen et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  22. An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions
    Priyanka Madhu, Caroline Benz, Leandro Simonetti, Matthew J. Winters, Mythili S. Subbanna, Johanna Kliche, Lidia Gomez-Lucas, Hazem M. Kotb, Izabella Krystkowiak, Dmitri Segal et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Bacterial Production of CDKL5 Catalytic Domain: Insights in Aggregation, Internal Translation and Phosphorylation Patterns
    Andrea Colarusso, Concetta Lauro, Luisa Canè, Flora Cozzolino, Maria Luisa Tutino · 2024 · International Journal of Molecular Sciences
  24. HSP 90 Is Required for Meiotic Resumption and Spindle Formation in Porcine Oocytes
    Jae-Min Sim, Hyeon-Ji Song, Song‐Hee Lee, Xiaohan Li, Cheng‐Lin Zhan, Qin‐Yue Lu, Ji-Dam Kim, Gyu-Hyun Lee, Xiang‐Shun Cui · 2025 · Reproduction in Domestic Animals
  25. Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1
    Desmond Prah Amoah, Rebecca Mercier, Gnin Alyousef, Jill L. Johnson, Paul LaPointe · 2025 · Protein Science
  26. Heat shock protein modulates cell expansion via ROS homeostasis
    Shulin Ren, Haiyan Wang, Yuling Jiao, Ying Wang · 2026 · New Phytologist
  27. Heat shock protein 90 as a vital signalling hub in Schistosoma mansoni : a master regulator of stem cell proliferation, development and survival
    Nancy Adamma Aguoru, Ruth Suzanne Kirk, Anthony John Walker · 2026 · Open Biology
  28. An isotype-specific phosphorylation of Hsp90 rewires co-chaperone regulations
    Tisya Banerjee, Elisabetta Moroni, Maximilian Riedl, Giorgio Colombo, Johannes Büchner · 2026 · Journal of Biological Chemistry
  29. Identification of nucleotide binding sites and repurposing of potential FDA-approved inhibitors against human HOP
    Gagandeep Singh, Tapan Kumar Chaudhuri · 2025 · Discover Chemistry.
  30. Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific
    Adelina Rabenius, Intisar Salim, Hilmar Lindstrom, Anastasiya Pak, Serhat Aktay, Anniina Vihervaara · 2026 · Cell Stress and Chaperones
  31. RAF1 as a standalone therapeutic target in KRAS-driven lung adenocarcinoma: No added efficacy from co-targeting ARAF, EGFR, or DDR1
    Laura de la Puente Ovejero, Ana Fernández-Rodríguez, Sarah Francoz, Gonzalo Aizpurua, Lucia Lomba-Riego, Matthias Drosten, Carmen Guerra, Mónica Musteanu, Mariano Barbacid, Sara García‐Alonso · 2026 · PLoS ONE
  32. Functional interplay between heat shock protein 90 (HSP90) and heat shock factors (HSFs)
    Abir Chakraborty, Lea Sistonen, Pia Roos‐Mattjus · 2026 · Cell Stress and Chaperones
  33. Redox-Encoded Proteostasis: Heat Shock Proteins as Integrators of Stress Adaptation and Therapeutic Targets
    Kangmiao Guo, Xingyao Li, Qiwei Liang, Chaolei Chen, Jiaqi Lin, Tiancheng Zhan, Chengpeng Sun, Ning Kang, Feng Xian Qiu, Qiang Zhang · 2026 · Antioxidants and Redox Signaling
  34. Protein Homeostasis Screen Identifies CK2 Inhibition as a Driver of CARD9 Depletion
    Aya M. Kelly, Leidy C. Merselis, Benjamin Causton, Olivia K. Calder, Hoson Chao, Margaret M. Prack, Laurel B. Stine, Yuka Amako, Tao Wang, Ali E. Yesilkanal et al. · 2026 · ACS Chemical Biology
  35. Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting
    Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shaogang Wang, Qi‐Dong Xia, Mengyao Xu · 2026 · MedComm
  36. Molecular Origins of Brain and Body Geometry
    Antonio Lima-de-Faria · 2014 · Springer eBooks
  37. Übereinstimmende Muster in Chaperon‐Interaktionen mit einem nativen Klientenprotein
    Lichun He, Sebastian Hiller · 2018 · Angewandte Chemie
  38. Exploring Genome-Wide Analysis of Heat Shock Proteins (HSPs) in Small Millets as Potential Candidates for Development of Multistress Tolerant Crop Plants
    Sharmistha Barthakur, Nandita Bharadwaj · 2022 · Springer eBooks
  39. Hsp70/Hsp90 Organizing Protein (HOP) Maintains CRAF Kinase Activity and Regulates MAPK Signaling by Enhancing Hsp90-CRAF Association
    Nilanjan Gayen, Sahana Mitra, Somesh Roy, Atin Kumar Mandal · 2026 · Molecular and Cellular Biology
  40. Ubiquitin-Derived Fragment as a Peptide Linker for the Efficient Cleavage of a Target Protein from a Degron
    Yuki Utsugi, Ken Nishimura, Satoshi Yamanaka, Kohei Nishino, Hidetaka Kosako, Tatsuya Sawasaki, Hideyuki Shigemori, Thomas J. Wandless, Yusaku Miyamae · 2024 · ACS Chemical Biology
  41. Profiling the Misfolded Proteome in Human Disease
    Vivian C. Onwudiwe, Joseph C. Genereux · 2024 · Israel Journal of Chemistry
  42. Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation
    Lixiao Zhang, Wei Liu, Zhen Zheng, Qiuyue Zhang, Yanyi He, Jinying Gu, Danni Wang, Huangliang Shu, Jia Yu, Jianfeng Liu et al. · 2024 · Angewandte Chemie
  43. Mechanisms and applications of mitochondrial chaperone inhibitors
    Gianna Mochi, Mark R. Woodford · 2025 · Transactions of the Royal Society of South Africa
  44. Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them
    Yan Zhong, Shi Li, Zhuo Xu, Jing Gao, Qingyu Ma, Tianqi Gao, Junying Tang, Muya Xiong, Yechun Xu, Huixiong Dai et al. · 2025 · Communications Biology
  45. HSP90 inhibition reverses resistance to TRAIL-induced apoptosis in non-small cell lung cancer cells
    Kaamar Azijli, Geng Xu, Rita Siino, Emilia Di Giovanni, Suravanan Yuvaraj Pillai, Sjors M. Kas, Antonio Giampiero Russo, Elisa Giovannetti, Steven de Jong, Godefridus J. Peters et al. · 2025 · Academia oncology.
  46. Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection
    Sehee Yun, Seoyeon Kim, Seong-Gyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee · 2025 · Advanced Science
  47. Self-Assembly: The Primary Source of Coherence
    Antonio Lima-de-Faria · 2014 · Springer eBooks
  48. Corticosteroid Receptors, Their Chaperones and Cochaperones: How Do They Modulate Adipogenesis?
    Judith Toneatto, Nancy L. Charó, Agostina Naselli, Melina Muñoz-Bernart, Antonella Lombardi, Graciela Piwien‐Pilipuk · 2014 · Nuclear Receptor Research
  49. The VHL short variant involves in protein quality control
    Yanbin Liu, Haixia Yang, Feifei Zuo, Liang Chen · 2016 · Gene
  50. Mechanisms of Protein Homeostasis Regulation in Cancer Development
    Filip Trčka, Petr Müller, Bořivoj Vojtěšek · 2016 · Klinicka onkologie
  51. Role of HSP90 Inhibitors in the Treatment of Cancer
    Geraldine O’Sullivan Coyne, Cecilia Monge, Alice P. Chen · 2019 · Heat shock proteins
  52. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products
    Yue Hu, Xiao J. Zhang, Xiao T. Yang, Ying Ying Tang, Lin Yu Hu, Dong Zhu · 2019 · Heat shock proteins
  53. Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90
    Lukas Schmauder, Eva Absmeier, Alexander Bepperling, Katalin Barkovits, Katrin Marcus, Klaus Richter · 2021 · Scientific Reports
  54. HSP90: A potential drug target in inflammatory skin diseases
    Anne Hald Rittig, Anne Bregnhøj, Claus Johansen, Lars Iversen · 2023 · JEADV Clinical Practice
  55. Refolding activity of bacterial Hsp90 in vivo reveals ancient chaperoning function
    Tania Morán Luengo, Toveann Ahlnäs, Anna T. Hoekstra, Celia R. Berkers, Matthias P. Mayer, Stefan Rüdiger · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Functional Genomic and Chemical Biology Analysis of Echinocandin Resistance in Candida albicans
    Tavia Caplan · 2018 · TSpace (University of Toronto)
  57. Vaccinia virus requires heat-shock proteins for genome replication and virion assembly
    Harriet G. W. Mok · 2019 · UCL Discovery (University College London)
  58. Activation and Stabilization of the Caspase-8 Survivalsome is Indispensable for Functional Toll-like Receptor 4 Dependent Signaling in Septic Neutrophils
    Sahil Gupta · 2020 · TSpace (University of Toronto)
  59. N-phosphonacetyl-L-aspartate enhances type I interferon anti-viral responses through activation of non-canonical NOD2 signaling
    András K. Ponti, Megan T. Zangara, Christine M. O’Connor, Erin E. Johnson, Christine McDonald · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  60. Hsp90-dependent triage of the glucocorticoid receptor via the CHIP E3 ubiquitin ligase
    Cynthia M. Chio, Feng Wang, Chari M. Noddings, David A. Agard · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Targeting Ectopic Hsp90 in Breast Cancer
    Jared James Barrott · 2014
  62. Targeting the Protein Quality Control (PQC) Machinery
    Pierfausto Seneci · 2015 · Elsevier eBooks
  63. Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
    Anniina Vihervaara · 2014 · Doria (University of Helsinki)
  64. Better with BACON
    Amy L. Donner · 2012 · Nature Chemical Biology
  65. Chaperones as thermodynamic sensors
    Harrison Charlotte · 2013 · Nature Reviews Drug Discovery
  66. Erythropoietin Stimulation of Mitochondrial Protein Content - A Potential Mechanism through Direct Binding of Erythropoietin Receptor and AMP-Activated Protein Kinase
    Michael N. Pham · 2014 · UA Campus Repository (The University of Arizona)
  67. Radioactive iodine labeling of monoclonal antibody against Hsp90α and its use in diagnostic imaging in prostate cancer xenograft model.
    Sun Hw, Wang Rf, Peng Yan, Zhang Cl, P Hao, Hui Ma, X-Q Chen · 2015 · PubMed
  68. Exploiting the Dependency of Cancer Cells on Molecular Chaperones
    Swee Y. Sharp, Jennifer E. Howes, Paul Workman · 2013 · Royal Society of Chemistry eBooks
  69. Targeting the Protein Quality Control (PQC) Machinery
    Pierfausto Seneci · 2015 · Elsevier eBooks
  70. The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed Lineage Kinase 3 and Mixed Lineage Kinase 4 Beta
    Natalya A. Blessing · 2015 · OhioLink ETD Center (Ohio Library and Information Network)
  71. Allosteric Modulators of Heat Shock Protein 90 (HSP90)
    Yen Chin Koay, Shelli R. McAlpine · 2016 · Royal Society of Chemistry eBooks
  72. Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
    Hong Wang · 2017
  73. The Effects of Withaferin A on Normal and Malignant Immune Cells
    Sara Samir Alhakeem, Mary Kathryn McKenna, Karine Z. Oben, Beth W. Gachuki, Sunil K. Noothi, Natarajan Muthusamy, Vivek M. Rangnekar, Ramesh C. Gupta, Subbarao Bondada · 2017 · Springer eBooks
  74. Determining the Mechanisms of Resistance to Drug Combinations and their Fitness Effects in Candida albicans
    Jessica A. Hill · 2014 · TSpace (University of Toronto)
  75. Determining mechanisms of sensitivity and resistance to HSP90 inhibition in non-small cell lung cancer
    Edward W. P. Law · 2016 · Figshare
  76. Development of versatile genetic tools to study a DYRK family kinase in Caenorhabditis elegans
    Yuemeng Wang · 2015
  77. Conformational Fluctuations of Biomolecules Studied Using Molecular Dynamics and Enhanced Sampling
    Geoffrey Gray · 2018 · Digital Commons - University of South Florida (University of South Florida)
  78. The impact of proteostasis imbalance on proteome solubility
    Xiaojing Sui · 2019 · Minerva Access (University of Melbourne)
  79. Heat Shock Protein 90 Inhibitors in Lung Cancer Therapy
    Suman Chatterjee, Timothy Francis Burns · 2019 · Heat shock proteins
  80. The Biosynthesis and Folding of Oily Peptide Chains
    Kai Li, Shi‐Qing Cai · 2019 · Springer eBooks
  81. Role of Hsp90 Interacting Molecular Chaperones on Tau and Aß Processing in Alzheimer’s Disease
    Liam Gracia, Gabriella Lora, Umesh K. Jinwal · 2019 · Heat shock proteins
  82. The adaptive potential of the middle domain of yeast Hsp90
    Pamela A. Cote-Hammarlof, Inês Fragata, Julia M. Flynn, David Mavor, Konstantin B. Zeldovich, Claudia Bank, Daniel N. A. Bolon · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  83. HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease
    Mario D. Galigniana · 2019 · Heat shock proteins
  84. Identifying vital genes of breast cancer through synergy network by part mutual information
    Xiaobo Yang, Binghui Guo, Zhilong Mi, Ziqiao Yin, Jiahui Li, Zhiming Zheng · 2020 · International Journal of Modern Physics C
  85. Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone system
    Rachel E. Lackie, Abdul R. Razzaq, Sali M.K. Farhan, Gilli Moshitzky, Flávio H. Beraldo, Marilene Hohmuth Lopes, Andrzej Maciejewski, Robert Gros, Jue Fan, Wing‐Yiu Choy et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  86. Regulation of Argonaute Proteins and Small RNA Pathways in Caenorhabditis elegans by CHORD Domain Protein-1 (CHP-1)
    Vivian Hei-Wan Cheung · 2015 · TSpace (University of Toronto)
  87. The role of the coding sequence in regulating human mRNA stability
    Ashrut Narula · 2018 · TSpace (University of Toronto)
  88. Protein Folding in Vivo
    Florian Georgescauld, F. Ulrich Hartl · 2015 · Encyclopedia of Life Sciences
  89. Como implicar a los bancos en la proteccion de los intereses del exportador
    Fernando Peña Osorio · 2000 · El Exportador
  90. Способность цитофлавина влиять на антиоксидантную систему защиты организма
    Olga A. Goroshko, О. А. Чеча, Е. Ю. Демченкова · 2011 · Биомедицина
  91. O-1-206 CD155/PVRを標的とした大腸癌に対する分子標的治療の基礎的検討(大腸 研究1,一般演題(口演),第63回日本消化器外科学会総会)
    徳之 河野, 隆 神垣, 康雄 今井, 眞一 安田, 大介 黒田, 孝博 藤盛, 嘉和 黒田 · 2008 · 日本消化器外科学会雑誌
  92. Faculty Opinions recommendation of A methylated lysine is a switch point for conformational communication in the chaperone Hsp90.
    Mehdi Mollapour · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  93. Design, synthesis, and evaluation of novel 3,4‐isoxazolediamide derivatives for the combination treatment of azole‐resistant candidiasis
    Lei Liu, Yixiang Sun, Zixuan Gao, Wenbo Yin, Hong Jiang, Tianxiao Wu, Yin Sun, Qiaohua Qin, Dongmei Zhao, Maosheng Cheng · 2022 · Archiv der Pharmazie
  94. Relative specificity as an important consideration in the big data era
    Xiaoxiao Zhang, Yan Zeng · 2022 · Frontiers in Genetics
  95. Stability of Steroid Hormone Receptors
    Zachary J. Gale-Day, Jason E. Gestwicki · 2022 · Wiley eBooks
  96. Data from Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription
    Lixia Liu, Yaotang Deng, Zhenming Zheng, Zihao Deng, Jinxin Zhang, Jieyou Li, Manfeng Liang, Xueqiong Zhou, Wenchong Tan, Hongjun Yang et al. · 2023
  97. Reviewer #2 (Public Review): Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
    Nathanael A. Caveney, Naotaka Tsutsumi, Garcia K Christopher · 2023 · eLife
  98. eLife Assessment: Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
    Mohamed Trebak · 2023 · eLife
  99. Reviewer #1 (Public Review): Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
    Nathanael A. Caveney, Naotaka Tsutsumi, Garcia K Christopher · 2023 · eLife
  100. Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
    Nathanael A. Caveney, Naotaka Tsutsumi, K. Christopher García · 2023 · eLife