Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Taipale, Mikko, Krykbaeva, Irina, Koeva, Martina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan·2012·Cell

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Items 201–300 of 879

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    Michelle D. Leach, Leah E. Cowen · 2013 · PLoS Pathogens
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  3. Hsp90 Promotes Kinase Evolution
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  4. Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis
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  5. Functions of the Hsp90 chaperone system: lifting client proteins to new heights.
    Julia M. Eckl, Klaus Richter · 2013 · Europe PMC (PubMed Central)
  6. Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses
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  8. Drosophila Spag Is the Homolog of RNA Polymerase II-associated Protein 3 (RPAP3) and Recruits the Heat Shock Proteins 70 and 90 (Hsp70 and Hsp90) during the Assembly of Cellular Machineries
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  14. Hsp90: From Cellular to Organismal Proteostasis
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  18. Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease
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  19. Hsp90 provides a platform for kinase dephosphorylation by PP5
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    Brian Foo, Brittany Williamson, Jason C. Young, Gergely L. Lukács, Alvin Shrier · 2015 · The Journal of Physiology
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  28. Human Hsp90 cochaperones: perspectives on tissue-specific expression and identification of cochaperones with similar in vivo functions
    Marissa E. Dean, Jill L. Johnson · 2020 · Cell Stress and Chaperones
  29. Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate
    Nuri Sung, Jungsoon Lee, Ji‐Hyun Kim, Changsoo Chang, A. Joachimiak, Sukyeong Lee, Francis Tsai · 2016 · Proceedings of the National Academy of Sciences
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  33. Protein Homeostasis at the Plasma Membrane
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  34. HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
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    Yunbin Xu, Fei Liu, Juan Liu, Dandan Wang, Yan Yan, Sen-Lin Ji, Jie Zan, Jiyong Zhou · 2016 · Scientific Reports
  47. Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex
    Xing Liu, D. J. Main, Yijie Ma, Bin He · 2018 · Journal of Virology
  48. Recent advances toward the development of Hsp90 C-terminal inhibitors
    Eva Amatya, Brian S. J. Blagg · 2022 · Bioorganic & Medicinal Chemistry Letters
  49. Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ
    Rie Sonamoto, Isao Kii, Yuka Koike, Yuto Sumida, Tomoe Kato‐Sumida, Yukiko Okuno, Takamitsu Hosoya, Masatoshi Hagiwara · 2015 · Scientific Reports
  50. The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation
    Xin‐an Lu, Xiaofeng Wang, Wei Zhuo, Lin Jia, Yushan Jiang, Yan Fu, Yongzhang Luo · 2013 · Biochemical Journal
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    Alina Röhl, Franziska Tippel, Evelyn Bender, Andreas B Schmid, Klaus Richter, Tobias Madl, Johannes Büchner · 2014 · EMBO Reports
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    Xinliu Li, Nicole Robbins, Teresa R. O’Meara, Leah E. Cowen · 2016 · Molecular Microbiology
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