The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction
Open accessAbstract
Summary The type 2 ryanodine receptor/calcium release channel (RyR2), required for excitation-contraction coupling in the heart, is abundant in the brain. Chronic stress induces catecholamine biosynthesis and release, stimulating β-adrenergic receptors and activating cAMP signaling pathways in neurons. In a murine chronic restraint stress model neuronal RyR2 were phosphorylated by protein kinase A (PKA), oxidized and nitrosylated, resulting in depletion of the stabilizing subunit calstabin2 (FKBP12.6) from the channel complex and intracellular calcium leak. Stress-induced cognitive dysfunction, including deficits in learning and memory, and reduced long-term potentiation (LTP) at the hippocampal CA3-CA1 connection, were rescued by oral administration of S107, a novel compound developed in our laboratory that stabilizes RyR2-calstabin2 interaction, or by genetic ablation of the RyR2 PKA phosphorylation site at serine 2808. Thus, neuronal RyR2 remodeling contributes to stress-induced cognitive dysfunction. Leaky RyR2 could be a therapeutic target for treatment of stress-induced cognitive dysfunction.
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Cites
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“There was a >2-fold sustained increase in plasma corticosterone (CORT) in WT and RyR2-S2808A+/+ mice following 3 weeks of chronic restraint stress (Aguilera, 1994; Carrasco and Van de Kar, 2003; McEwen, 2004, 2007) (Figure 1B and Figure S1C available online).”
BackgroundOrganization for physiological homeostasis
Cannon, W. B. (1929) · Physiological Reviews · doi:10.1152/physrev.1929.9.3.399 · Cited by 1,844
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Neuroendocrine pharmacology of stress
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“, 1998), suggesting long-term chronic stress (Miller and McEwen, 2006; Sherin and Nemeroff, 2011).”
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“Moreover, it has been proposed that these effects could underlie neuropsychiatric disorders and PTSD (Airan et al., 2007; Mirescu and Gould, 2006).”
BackgroundRole of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder
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Regulation of pituitary ACTH secretion during chronic stress
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“There was a >2-fold sustained increase in plasma corticosterone (CORT) in WT and RyR2-S2808A mice following 3 weeks of chronic restraint stress (Aguilera, 1994; Carrasco and Van de Kar, 2003; McEwen, 2004, 2007) (Figure 1B and Figure S1C available online).”
BackgroundRyanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
Andersson, D. C., Betzenhauser, M. J., Reiken, S., Meli, A. C., Umanskaya, A., Xie, W., Shiomi, T., Zalk, R., Lacampagne, A., & Marks, A. R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.014 · Cited by 424
Cited by
Finsterwald, C., & Alberini, C. M. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.09.017 · Cited by 320
Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals
de Juan-Sanz, J., Holt, G. T., Schreiter, E. R., de Juan, F., Kim, D. S., & Ryan, T. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.010 · Cited by 267
La Rovere, R. M. L., Roest, G., Bultynck, G., & Parys, J. B. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.04.005 · Cited by 257
Lacampagne, A., Liu, X., Reiken, S., Bussiere, R., Meli, A. C., Lauritzen, I., Teich, A. F., Zalk, R., Saint, N., Arancio, O., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1733-7 · Cited by 181
Self-citationThe aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology
Paspalas, C. D., Carlyle, B. C., Leslie, S., Preuss, T. M., Crimins, J. L., Huttner, A. J., van Dyck, C. H., Rosene, D. L., Nairn, A. C., & Arnsten, A. F. T. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.005 · Cited by 140
Metadata
- Authors
- Liu, X., Betzenhauser, M. J., Reiken, S., Meli, A. C., Xie, W., Chen, B.-X., Arancio, O., & Marks, A. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 150
- Issue
- 5
- Pages
- 1055-1067
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2105092954
- Cited by
- 162
- References
- 13
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, X., Betzenhauser, M. J., Reiken, S., Meli, A. C., Xie, W., Chen, B.-X., Arancio, O., & Marks, A. R. (2012). Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction. Cell. https://doi.org/10.1016/j.cell.2012.06.052
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