Cited by 751Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchChild Abuse and Trauma

Post-traumatic stress disorder: the neurobiological impact of psychological trauma

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Sherin, Jonathan E., Nemeroff, Charles B.·2011·Dialogues in Clinical Neuroscience

Abstract

The classic fight-or-flight response to perceived threat is a reflexive nervous phenomenon thai has obvious survival advantages in evolutionary terms. However, the systems that organize the constellation of reflexive survival behaviors following exposure to perceived threat can under some circumstances become dysregulated in the process. Chronic dysregulation of these systems can lead to functional impairment in certain individuals who become "psychologically traumatized" and suffer from post-traumatic stress disorder (PTSD), A body of data accumulated over several decades has demonstrated neurobiological abnormalities in PTSD patients. Some of these findings offer insight into the pathophysiology of PTSD as well as the biological vulnerability of certain populations to develop PTSD, Several pathological features found in PTSD patients overlap with features found in patients with traumatic brain injury paralleling the shared signs and symptoms of these clinical syndromes.

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Authors
Sherin, J. E., & Nemeroff, C. B.
Affiliations
University of Miami (US)
Corresponding author
Sherin, Jonathan E.
Venue
Dialogues in Clinical Neuroscience
Published
2011-09-30
Volume
13
Issue
3
Pages
263-278
ISSN
  • 1294-8322 (ISSN-L)
  • 1958-5969
OpenAlex
W1548863913
Cited by
750
References
95
Citations by year
2026: 56 · 2025: 76 · 2024: 86 · 2023: 67 · 2022: 55 · 2021: 71 · 2020: 38 · 2019: 54 · 2018: 59 · 2017: 54 · 2016: 40 · 2015: 43 · 2014: 30 · 2013: 15 · 2012: 6
FWCI
17.61
Type
journal article
Language
en
Open access
Locations
  • Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
post-traumatic stress disorder, psychological trauma, fight-or-flight response, threat perception, biological vulnerability, pathophysiology, traumatic brain injury
MeSH terms
Endocrine System, Humans, Hypothalamo-Hypophyseal System, Neurobiology, Neurochemistry, Risk Factors, Stress Disorders, Post-Traumatic, Stress, Psychological

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