Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Bar-Peled, Liron, Schweitzer, Lawrence D., Zoncu, Roberto, Sabatini, David M.·2012·Cell

Cited by (914)

Items 801–900 of 914

  1. Lipid Sensing by Mammalian Target of Rapamycin
    Deepak Menon · 2017 · CUNY Academic Works (City University of New York)
  2. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
    Robert A. Saxton, Rachel L. Wolfson, Lynne Chantranupong, Timothy C. Wang, Thomas Schwartz, David M. Sabatini, Kevin E. Knockenhauer, Michael E. Pacold · 2016 · DSpace@MIT (Massachusetts Institute of Technology)
  3. Homeostatic role of acid sphingomyelinase in mtor signaling and autophagy
    Matthew J. Justice · 2016 · IUScholarWorks (Indiana University)
  4. Computer simulation of a large-scale signalling network regulating translation Initiation in the mammalian cell.
    David Ward Taylor · 2017 · Surrey Research Insight Open Access (The University of Surrey)
  5. VIRAL REGULATION OF CAP-DEPENDENT MESSENGER RNA TRANSLATION INHIBITOR 4E-BP1 DURING MITOSIS
    Celestino Velásquez · 2017 · D-Scholarship@Pitt (University of Pittsburgh)
  6. The Adaptor Protein p66SHC: Roles in Cell Signaling, Metabolism and Growth
    Mohamed A. Soliman · 2014 · TSpace (University of Toronto)
  7. The role of glutamine in the regulation of mTOR signalling in pancreatic β-cells
    Ghazi Alghanim · 2017 · Leicester Research Archive (University of Leicester)
  8. Nutrition for Strength Adaptations
    H. Zbinden, Alec M. Avey, K. Baar · 2018 · Nutrition and Enhanced Sports Performance
  9. mTOR under stress
    Alexander Martin Heberle · 2019 · University of Groningen research database (University of Groningen / Centre for Information Technology)
  10. Chronic Dietary Supplementation of Branched-Chain Amino Acids Does Not Attenuate Muscle Torque Loss in a Mouse Model of Duchenne Muscular Dystrophy
    Justin E. Sperringer · 2019 · VTechWorks (Virginia Tech)
  11. The lysosomal V-ATPase B1 subunit in renal proximal tubule is linked to nephropathic cystinosis
    Amer Jamalpoor, Albertien M. van Eerde, Marc R. Liliën, Charlotte A. G. H. van Gelder, Esther A. Zaal, Floris A. Valentijn, Roel Broekhuizen, Eva Zielhuis, Julia E. Egido, Maarten A. F. Altelaar et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Effect of Branched-Chain Alpha-Keto Acid Dehydrogenase Depletion on Myotube Protein Metabolism
    Glory Madu · 2020 · YorkSpace (York University)
  13. Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1 Oncogene
    Eugènia Almacellas, Ànna Manzano, Antonio Gentilella, Santiago Ambrosio, Caroline Mauvezin, Albert Tauler · 2019 · SSRN Electronic Journal
  14. Investigating the pathophysiology and potential therapeutic approaches for nephropathic cystinosis
    Amer Jamalpoor · 2021
  15. V-ATPase Deficiency Aggravates Hypoxia-induced Spermatogenesis Reduction by Promoting Spermatocyte Apoptosis via the JNK/c-Jun Pathway in Mice
    Jun Yin, Juan He, Fei Han, Zhi qi Gao, Fang Deng, Wei-gong Liao, Meng jie Zhang, Qiu Hu, Zhi fang Li, Gang Zhang et al. · 2021 · Research Square
  16. HBXIP contributes to radioresistance through NF-κB-mediated expression of XIAP in breast cancer
    Xiaofei Chu, Wang Zheng, Qianping Chen, Chen Wang, Saijun Fan, Chunlin Shao · 2021 · Radiation Medicine and Protection
  17. Mechanistic target of rapamycin complex 1 (mTORC1) activity occurs predominantly in the periphery of human skeletal muscle fibers, in close proximity to focal adhesion complexes, following anabolic stimuli
    Nathan W. Hodson, Michael Mazzulla, Dinesh Arun Kumbhare, Daniel R. Moore · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
    Kai‐Min Lin · 2021 · Apollo (University of Cambridge)
  19. Optimizing protein delivery to promote skeletal muscle protein synthesis
    José L. Areta · 2014 · RMIT Research Repository (RMIT University Library)
  20. Regulation of the Mechanistic Target of Rapamycin by Cellular Stress.
    Brian Magnuson · 2013 · Deep Blue (University of Michigan)
  21. Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1
    Yan Qin, Peiling Ni, Qingye Zhang, Xiao Wang, Xiaoling Du, Zixi Yin, Lingling Wang, Lihong Ye, Lingyi Chen · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Faculty Opinions recommendation of mTOR at the nexus of nutrition, growth, ageing and disease.
    Shawn M. Ferguson · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  23. Faculty Opinions recommendation of Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
    Christopher G. Proud · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  24. Rag GTPases
    Jenna L. Jewell, Kun‐Liang Guan · 2014 · Springer eBooks
  25. Amino Acids in the Treatment of Neurologic Disorders
    Adam L. Hartman · 2022
  26. The Greatwall-Endosulfine-PP2A/B55 pathway in Schizosaccharomyces pombe: regulatory mechanisms and roles in cell differentiation and ageing
    Natalia García-Blanco · 2021
  27. Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms
    Jason Workman · 2016
  28. Unravelling novel functions of the MTOR network across subcellular compartments
    Marti Cadena Sandoval · 2022
  29. Mechanisms Of Organelle Identity and Adaptation In Immune Cells
    Victoria E. B. Hipolito · 2021
  30. Amino acids stimulate the endosome-to-golgi trafficking through ragulator and small GTPase Arl5
    Bing Chen · 2018
  31. Regulation of lysosome biogenesis by phosphoinositides and phagocytosis
    Christopher Choy · 2021
  32. Impacto da via de sinalização AMPK na modulação da resposta imune antitumoral por linfócitos T CD4>sup<+>/sup< e CD8>sup<+>/sup<
    Amanda Campelo Melo Feitosa · 2020
  33. Faculty Opinions recommendation of Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
    Will Prinz · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  34. Faculty Opinions recommendation of Structural basis for the docking of mTORC1 on the lysosomal surface.
    Brett M. Collins · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  35. Mitogenic and Metabolic signals regulate mTOR complex 1 function to control GSK3β nuclear program
    Stephen James Bautista · 2021
  36. The deubiquitinase USP32 regulates non-proteolytic ubiquitination in the endosomal-lysosomal system
    Alexandra Hertel · 2021
  37. Faculty Opinions recommendation of A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability.
    Zu‐Hang Sheng, Tamar Farfel‐Becker · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  38. Mechanisms Of Organelle Identity and Adaptation In Immune Cells
    Victoria E. B. Hipolito · 2021
  39. References
    2014 · Elsevier eBooks
  40. Faculty Opinions recommendation of Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
    Shawn M. Ferguson · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  41. Faculty Opinions recommendation of Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
    Brett M. Collins · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  42. Faculty Opinions recommendation of The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex.
    David Anthony Lyons, Rafael Almeida · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  43. Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis
    Jae‐Il Park, Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn‐Sang Jung, Sohee Jun, Jie Zhang, Esther M. Lien et al. · 2022 · Research Square
  44. Homeostatic feedback between lysosomal mTORC1 and mTORC2-AKT signaling controls nutrient uptake in brown adipose tissue
    Gudrun Liebscher, Nemanja Vujić, Renate Schreiber, Markus Heine, Caroline Krebiehl, Madalina Duta-Mare, Giorgia Lamberti, Cedric H. De Smet, Michael W. Hess, Thomas Oliver Eichmann et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  45. mTORC1: Upstream and Downstream
    Yao Yao, Ken Inoki · 2022 · Elsevier eBooks
  46. Elucidating the molecular pathology of DEPDC5 mutation induced mTOR-hyperactivation associated with epilepsy and autism spectrum disorder
    Mattson Jones · 2022
  47. Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation
    Victoria E. B. Hipolito, Jacqueline A. Diaz, Kristofferson V. Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Sarić, Shannon McLaughlan, Ola Segnestam Larsson, Ivan Topisirović et al. · 2023
  48. The Lysosome Signaling Platform: Adapting With the Times
    Subothan Inpanathan, Roberto Botelho · 2023
  49. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells
    Amra Sarić, Victoria E. B. Hipolito, Jason G. Kay, Johnathan Canton, Costin N. Antonescu, Roberto Botelho · 2023
  50. Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation
    Victoria E. B. Hipolito, Jacqueline A. Diaz, Kristofferson V. Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Sarić, Shannon McLaughlan, Ola Segnestam Larsson, Ivan Topisirović et al. · 2023
  51. Lysosomal pH Gradient is Required for Lysosomal Tubulation in Macrophage Cells
    Shiraz Anwar · 2023
  52. Lysosomal pH Gradient is Required for Lysosomal Tubulation in Macrophage Cells
    Shiraz Anwar · 2023
  53. mTOR signaling and autophagy regulation
    Amruta Singh, Sujit K. Bhutia · 2023 · Elsevier eBooks
  54. Estudos das relações evolutivas e funcionais da proteina viral HBx com as subunidades do complexo Ragulator
    Jordy Alexander Larco Lasso · 2021
  55. Caracterização das isoformas e interações da proteína HBXIP/Lamtor5, uma subunidade do complexo Ragulator
    Mariana Piccoli Gonçalves · 2021
  56. The Molecular Logic of Gtr1/2 and Pib2 Dependent TORC1 Regulation in Budding Yeast
    Jacob H. Cecil, Cristina M. Padilla, Austin A. Lipinski, Paul R. Langlais, Xiangxia Luo, Andrew P. Capaldi · 2024 · eLife
  57. Metabolic control of immunopathogenesis in systemic lupus erythematosus
    András Perl · 2024 · Elsevier eBooks
  58. Vacuolar pH regulates clathrin-mediated endocytosis through TORC1 signaling during yeast replicative aging
    Kenneth Gabriel Antenor, Jaime Lee-Dadswell, Nina Grishchenko, Shaimaa Swaleh, Allie Spangaro, Mojca Mattiazzi Ušaj · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Resistance Exercise and Alcohol: Combined Effects on Physiology and Performance
    D. Levitt · 2018
  60. The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages
    Magdalena Circu, Reneau Castore, Brian Latimer, S. Shames, C. Roy, A. Dragoi, S. Ivanov · 2026 · PLoS Pathogens
  61. Developing epidermis acquires nutrients from the external milieu by mTOR-dependent macropinocytosis
    Shravani Reddy Shetty, Arnab Chakraborty, Shivali Dongre, Siddhesh S. Kamat, Mahendra S. Sonawane · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Single-cell Resolution Spatial Transcriptomics Delineates the Inflammatory Landscape of Human Dental Pulp: Regional Crosstalk and Therapeutic Implications
    Jianmao Zheng, Fengyuan Zhang, Yuanyuan Kong, Xiaobin Fu, Jiyuan Zuo, Qining Guo, Jiayi Wang, Manlin Xu, Qian Zeng, Yuejiao Zhang et al. · 2025 · Research Square
  63. Phospho-Proteomic Analysis of Interleukin-13 Signaling in Airway Cells Reveals SRC Family Kinase Involvement in Interleukin-13-Induced Inflammatory Responses
    Archana Shankar, Jaclyn W. McAlees, Michael A. Wyder, Julie M. Hargis, Harshavardhana H. Ediga, Angela Cannata, Jana Latayan, Kenneth D. Greis, Satish Kumar Madala, Ian Paul Lewkowich · 2025 · International Archives of Allergy and Immunology
  64. Additional file 2 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
    Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen et al. · 2021 · Figshare
  65. Additional file 4 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
    Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen et al. · 2021 · Figshare
  66. Additional file 3 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
    Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen et al. · 2021 · Figshare
  67. Additional file 1 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
    Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen et al. · 2021 · Figshare
  68. TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop
    Andreas A. Lamprakis, Constantinos Demetriades · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  69. Lysosomal acid lipase is essential in cholesterol-mediated mTORC1 signaling activation by maintaining a balance between cholesterol ester and free cholesterol in zebrafish
    Rui-Xin Li, Yuan Luo, Si‐Lan Han, Wenhao Zhou, Li-Qiao Chen, Fang Qiao, Wuying Chu, Meiling Zhang, Zhen-Yu Du · 2026 · Water Biology and Security
  70. Acides aminés et cancer : LAT1, un transporteur essentiel à l’activité mTORC1 et la croissance tumorale
    Yann Cormerais · 2016 · theses.fr (ABES)
  71. Lysosomal degradation of insulin granules promotes β-cell failure in type 2 diabetes
    Adrien Pasquier · 2016
  72. Regulation of Autophagy by Acetyl Coenzime A : From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics
    Federico Pietrocola · 2015 · theses.fr (ABES)
  73. Modulation de la réponse immune par IL4I1 : rôle dans les évènements précoces d’activation lymphocytaire T
    Aude Aubatin · 2016
  74. Mécanisme d’activation neuronale de mTORC1 et de son altération par le peptide amyloïde β
    Dany Khamsing · 2017 · theses.fr (ABES)
  75. Impact de l’enzyme Interleukin-4 induced gene 1 (IL4I1) sur les populations lymphocytaires T régulatrices
    Céline Cousin · 2014 · theses.fr (ABES)
  76. Implications de l’homéostasie énergétique dans la croissance, l’autophagie et la physiologie de l’intestin chez Drosophila melanogaster
    Maëlle Devilliers · 2018
  77. Caractérisation phénotypique et moléculaire des dysplasies frontonasales
    Daphné Lehalle · 2017
  78. Exploring the Role of Intercellular and Intracellular Signaling in the Sustenance of Glioblastoma Stem-like Cells
    Kathryn Jacobs · 2020 · theses.fr (ABES)
  79. Implication de la GTPase RagA dans l’activation et la polarisation de la réponse lymphocytaire T
    Mehdi Attia · 2017
  80. Réponse macrophagique aux nanomatériaux carbonés : effets de leur caractéristiques physiques et chimiques sur le transcriptome
    Sara Nahle · 2019
  81. Role of p27/Kip1 in auphagy under metabolic stress conditions
    Ada Nowosad · 2018
  82. Protéinuries génétiques causées par déficit de réabsorption tubulaire proximale
    Mathilde Bedin · 2019
  83. Overcoming drug resistance in diffuse large b-cell lymphoma by targeting cell metabolism and the alternative NF-kB pathway
    Stéphanie Nuan-Aliman · 2021 · theses.fr (ABES)
  84. Identification and functional characterization of the neuronal protein VhaAC45L in Drosophila
    Amina Dulac · 2021
  85. Regulation of the Akt/mTORC1 Pathway by HIV Transcriptional Activator Tat in B Cells
    Burkitkan Akbay · 2021 · theses.fr (ABES)
  86. Role of the mTOR-downstream effector S6K1 in tuberous sclerosis complex neurological manifestations
    Francesco Avanzi · 2023 · theses.fr (ABES)
  87. The role of GATOR1 complex, upstream regulator of mTORC1 pathway, in mitochondrial function
    Yahir A. Loissell-Baltazar · 2022 · theses.fr (ABES)
  88. Régulation de cohésine par le complexe TORC1 chez la levure Schizosaccharomyces pombe
    Dorian Besson · 2024 · theses.fr (ABES)
  89. Rôle cellulaire et développemental du transporteur lysosomal PQLC2 dans un modèle murin
    Solène Lebrun · 2023 · theses.fr (ABES)
  90. Elucidating the Vulnerability of Glioblastoma Stem-like Cells to Lysosomal Dysfunctions
    Clément Maghe · 2023 · theses.fr (ABES)
  91. Time-Course Transcriptomic Analysis of Early Host Responses to Oral SfMNPV Challenge in Spodoptera frugiperda Larval Midgut
    Lin Guo, Wenyi Jin, Yan Tong, Huixian Shi, Qin Kang, Jihong Zhang, Qian Meng, Xuan Li, Hongtuo Wang, Qilian Qin et al. · 2026 · Insects
  92. Functional characterization of the GATOR1 complex in cisplatin resistance
    Zhenrui Pan · 2024
  93. The role of the GATOR1 complex in mitochondrial function and quality control
    Hanxiao Zhang · 2025 · theses.fr (ABES)
  94. Signal sensing and transmission of amino acids in mTORC1 regulation
    Huan Zeng, Ruotong Li, Juan Li, Xiaoxiao Song, Ming-Yuan Su · 2026 · Oral Science and Homeostatic Medicine
  95. Lysosomal function and homeostasis: From cellular adaptation to disease pathogenesis
    Satoshi Minami, Maho Hamasaki · 2026 · International review of cytology
  96. HOPS is required for non-canonical mTORC1 signaling by recruiting Rags and FLCN to lysosomal membranes
    R. V. D. van der Welle, J. A. van der Beek, P. Sanza, F. Zwartkruis, N. Liv, J. Klumperman · 2026 · bioRxiv
  97. TORC1 integrates metabolic state transitions during aging
    Trishia Yi Ning Cheng, Arshia Naaz, 高铭彤, Wu Hao, Yizhong Zhang, Liang Cui, Jovian Jing Lin, Sonia Yogasundaram, Nashrul Afiq Faidzinn, Ong Yong Qing Victoria et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  98. The SLC15A4–LAMTOR1 interaction licenses endolysosomal TLR-mediated mTOR signaling and inflammatory cytokine production
    Tzu-Yuan Chiu, Peter-Rory Hall, Daniel C. Lazar, Arthur Kim, Stefano Forli, Andrew B. Ward, John Ross Teijaro, Christopher G. Parker · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  99. Cross-Disorder Pruning-Plasticity-Aging Architecture in Substance Use Disorders and Anxiety: Transcriptome-Wide Association Insights and Mechanistic Synthesis
    Ngo Cheung · 2026 · Cureus
  100. Opposing Ageing-Related Transcriptomic Profiles Distinguish Opioid Exposure Liability From Dependence Liability
    Ngo Cheung · 2026 · Cureus