Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

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Items 101–200 of 914

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4. BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon
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6. Targeting lysosomes in human disease: from basic research to clinical applications
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9. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling
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10. AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
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11. Role of amino acid transporters in amino acid sensing
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12. Structural basis for the docking of mTORC1 on the lysosomal surface
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13. Intracellular complement − the complosome − in immune cell regulation
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14. Regulation and function of V-ATPases in physiology and disease
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15. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
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16. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles
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17. Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
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18. Organelle-Specific Initiation of Autophagy
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19. Metformin extends C. elegans lifespan through lysosomal pathway
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20. T‐cell metabolism governing activation, proliferation and differentiation; a modular view
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21. The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives
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22. NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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23. The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia
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24. Eukaryotic V-ATPase: Novel structural findings and functional insights
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25. The lysosome: a crucial hub for AMPK and mTORC1 signalling.
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28. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
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29. mTOR signaling in stem and progenitor cells
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30. Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity*
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31. Regulation of autophagy by amino acids and MTOR-dependent signal transduction
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32. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
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33. Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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35. Structural Mechanism of a Rag GTPase Activation Checkpoint by the Lysosomal Folliculin Complex
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36. Lysosome: The metabolic signaling hub
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37. Covalent Targeting of the Vacuolar H+-ATPase Activates Autophagy Via mTORC1 Inhibition
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38. Regulation of Body Size and Growth Control
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39. Lysosomal Ion Channels as Decoders of Cellular Signals
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40. Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis
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41. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress
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42. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
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43. The expanding role of mTOR in cancer cell growth and proliferation
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45. Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat
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46. Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
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48. The Lysosome Signaling Platform: Adapting With the Times
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51. Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
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52. mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
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53. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
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54. Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
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56. mTORC1 pathway in DNA damage response.
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57. Architecture of human Rag GTPase heterodimers and their complex with mTORC1
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58. High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells
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59. Therapeutic Strategies Impacting Cancer Cell Glutamine Metabolism
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60. M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment
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61. Lysosomal quality control of cell fate: a novel therapeutic target for human diseases
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62. Dynamic Visualization of mTORC1 Activity in Living Cells
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63. p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth
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64. Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly
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65. The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
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66. Intersection of mTOR and STAT signaling in immunity
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67. mTOR and lysosome regulation
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68. The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1
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69. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
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70. mTOR: A Cellular Regulator Interface in Health and Disease
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71. Advances in Autophagy Regulatory Mechanisms
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72. A recollection of mTOR signaling in learning and memory
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73. Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex
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74. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
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75. Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches
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76. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells
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77. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
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78. Synchronizing transcriptional control of T cell metabolism and function
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79. Lysosomal signaling in control of degradation pathways.
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80. A Ragulator–BORC interaction controls lysosome positioning in response to amino acid availability
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81. Dynamics of mTORC1 activation in response to amino acids
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82. Lysosomal adaptation: how the lysosome responds to external cues
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83. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
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84. Lysosome Positioning Influences mTORC2 and AKT Signaling
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85. The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
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86. A lysosome-centered view of nutrient homeostasis
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87. Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway
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88. Pleiotropic Effects of mTOR and Autophagy During Development and Aging
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89. Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance
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90. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
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91. SEACing the GAP that nEGOCiates TORC1 activation
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92. Macropinocytosis, mTORC1 and cellular growth control
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93. The Lysosome at the Intersection of Cellular Growth and Destruction
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94. Amino acid management in cancer
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95. Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die
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96. Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease
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97. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1
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98. The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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99. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3
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100. Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
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