Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

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Items 201–300 of 914

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8. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold
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9. New developments in AMPK and mTORC1 cross-talk
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11. Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
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12. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
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13. Rheb and Rags come together at the lysosome to activate mTORC1
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15. Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling
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16. Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling
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18. Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
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21. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
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28. Modulation of mTOR signaling as a strategy for the treatment of Pompe disease
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29. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
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35. Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade
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36. Regulation of metabolic health by essential dietary amino acids
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37. mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus
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38. AMP-activated protein kinase – not just an energy sensor
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39. Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino acid-dependent mTORC1 hyperactivation by recruiting GATOR1
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40. An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation
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41. The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia
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42. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway
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43. Plant target of rapamycin signaling network: Complexes, conservations, and specificities
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44. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth
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45. mTORC1 senses stresses: Coupling stress to proteostasis
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46. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
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47. Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy
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50. Molecular Architecture and Function of the SEA Complex, a Modulator of the TORC1 Pathway*
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51. Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin
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52. Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling
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56. Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling
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57. Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19
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58. Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2
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59. The Architecture of the Rag GTPase Signaling Network
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60. Drug discovery targeting the mTOR pathway
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61. A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
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62. The post‐translational regulation of transcription factor EB (TFEB) in health and disease
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63. Liver Autophagy in Anorexia Nervosa and Acute Liver Injury
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64. Structural basis for the assembly of the Ragulator-Rag GTPase complex
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66. Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity
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67. The Target of Rapamycin and Mechanisms of Cell Growth
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68. GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids
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69. Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
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71. SEA you later alli-GATOR – a dynamic regulator of the TORC1 stress response pathway
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74. Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9
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75. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
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76. MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation
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77. Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling
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95. Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
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100. Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances
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