Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

Lian, Christine Guo, Xu, Yufei, Ceol, Craig, Wu, Feizhen, Larson, Allison, Dresser, Karen, Xu, Wenqi, Tan, Li +23 more·2012·Cell

DOI 10.1016/j.cell.2012.07.033

Cited by (811)

Items 101–200 of 811

Global DNA 5‐Hydroxymethylcytosine and 5‐Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma
Jiao Liu, Jinhua Jiang, Jiezhen Mo, Dan Liu, Dan Cao, Hailin Wang, Yufei He, Hongyang Wang · 2018 · Hepatology
Genetics of metastasis: melanoma and other cancers
Noel Turner, Olivia R. Ware, Marcus Bosenberg · 2018 · Clinical & Experimental Metastasis
Non‐canonical Bases in the Genome: The Regulatory Information Layer in DNA
Thomas Carell, Matthias Q. Kurz, Markus Müller, Martin Rossa, Fabio Spada · 2017 · Angewandte Chemie International Edition
Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer
Diego Camuzi, Ísis Salviano Soares de Amorim, Luís Felipe Ribeiro Pinto, Leonardo Oliveira Trivilin, André Luiz Mencalha, Sheila Coelho Soares‐Lima · 2019 · Cells
Nanopores Discriminate among Five C5-Cytosine Variants in DNA
Zachary L. Wescoe, Jacob Matthew Schreiber, Mark A. Akeson · 2014 · Journal of the American Chemical Society
Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma
Cheng, Phil F, Shakhova, Olga, Widmer, Daniel S, Eichhoff, Ossia M, Zingg, Daniel, Frommel, Sandra C, Belloni, Benedetta, Raaijmakers, Marieke IG, Goldinger, Simone M, Santoro, Raffaella et al. · 2015 · Genome Biology
Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma
Jasper Wouters, Miguel Vizoso, Anna Martínez‐Cardús, F. Javier Carmona, Olivier Govaere, Teresa Laguna, Jesuchristopher Joseph, Peter Dynoodt, Claudia Monica Aura, Mona Foth et al. · 2017 · BMC Medicine
Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer
Douglass W. Tucker, Christopher R. Getchell, Eric T. McCarthy, Anders Öhman, Naoko Sasamoto, Shuyun Xu, Joo Yeon Ko, Mamta Gupta, Amy L. Shafrir, Jamie E. Medina et al. · 2017 · Clinical Cancer Research
Immunity drives TET1 regulation in cancer through NF-κB
Évelyne Collignon, Annalisa Canale, Clémence Al Wardi, Martin Bizet, Emilie Calonne, Sarah Dedeurwaerder, Soizic Garaud, Céline Naveaux, Whitney Jo Barham, Andrew J. Wilson et al. · 2018 · Science Advances
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
Virginia López, A. Fernández, M. Fraga · 2017 · Ageing Research Reviews
5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer
Leonie I. Kroeze, Bert A. van der Reijden, Joop H. Jansen · 2015 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
Thomas Strub, Flávia G. Ghiraldini, Saul Carcamo, Man Li, Aleksandra Wroblewska, Rajendra Singh, Matthew S. Goldberg, Dan Hasson, Zichen Wang, Stuart J. Gallagher et al. · 2018 · Nature Communications
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
Arne Klungland, Adam B. Robertson · 2016 · Free Radical Biology and Medicine
Unlocking epigenetic codes in neurogenesis
Bing Yao, Peng Jin · 2014 · Genes & Development
TET2 in Normal and Malignant Hematopoiesis
Robert L. Bowman, Ross L. Levine · 2017 · Cold Spring Harbor Perspectives in Medicine
Epigenetic reprogramming of melanoma cells by vitamin C treatment
Gustafson, Christopher B, Yang, Cuixia, Dickson, Kevin M, Shao, Hongwei, Van Booven, Derek, Harbour, J William, Liu, Zhao-Jun, Wang, Gaofeng · 2015 · Clinical Epigenetics
Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update
Leigh A. Compton, George F. Murphy, Christine Guo Lian · 2015 · Dermatopathology
DNA Methylation in Cancer: A Gene Silencing Mechanism and the Clinical Potential of Its Biomarkers
Shinichi Fukushige, Akira Horii · 2013 · The Tohoku Journal of Experimental Medicine
Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver
John P. Thomson, Jennifer M. Hunter, Harri Lempiäinen, Arne Müller, Rémi Terranova, Jonathan G. Moggs, Richard R. Meehan · 2013 · Nucleic Acids Research
Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
Qi Cui, Yang Su, Peng Ye, Erpo Tian, Guoqiang Sun, Jiehua Zhou, Guihua Sun, Xiaoxuan Liu, Chao Chen, Kiyohito Murai et al. · 2016 · Nature Communications
TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
Jian Wu, Hongzhe Li, Minmin Shi, Youwei Zhu, Yang Ma, Yiming Zhong, Cheng Xiong, Hao Chen, Chenghong Peng · 2019 · Journal of Experimental & Clinical Cancer Research
Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency
Dewei Jiang, Ying Zhang, Ronald P. Hart, Jianmin Chen, Karl Herrup, Jiali Li · 2015 · Brain
Friend or foe—IDH1 mutations in glioma 10 years on
L Eric Huang · 2019 · Carcinogenesis
DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR
Goran Micevic, Viswanathan Muthusamy, William Damsky, Nicholas Theodosakis, Xiaoni Liu, Katrina M. Meeth, Emily Wingrove, Manjula Santhanakrishnan, Marcus Bosenberg · 2016 · Cell Reports
Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine
Monica Yun Liu, Hedieh Torabifard, Daniel J. Crawford, Jamie E. DeNizio, Xing-Jun Cao, Benjamin Aaron Garcia, Gerardo Andrés Cisneros, Rahul M. Kohli · 2016 · Nature Chemical Biology
Melanoma epigenetics: novel mechanisms, markers, and medicines
Jonathan J. Lee, Gëorge F. Murphy, Christine Guo Lian · 2014 · Laboratory Investigation
Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development
Daniel Nettersheim, Lukas Carl Heukamp, Florian Fronhoffs, Marc J Grewe, Natalie Haas, Anke Waha, Friedemann U. Honecker, Andreas Waha, Glen Kristiansen, Hubert Schorle · 2013 · PLoS ONE
Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
Jiangjiang Li, Ya He, Zheqiong Tan, Jingchen Lu, Liling Li, Xin Song, Feng Shi, Longlong Xie, Shuo You, Xiangjian Luo et al. · 2018 · Theranostics
Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate
Kevin M. Dickson, Christopher B. Gustafson, Juan I. Young, Stephan L. Zuchner, Gaofeng Wang · 2013 · Biochemical and Biophysical Research Communications
Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer
Yang Liu, San-Jian Yu, Hong Qi, Yu Yang, Zhi‐Ming Shao · 2015 · PLoS ONE
Cancer Epigenetics: New Therapies and New Challenges
Eleftheria ChR. Hatzimichael, Tim Crook · 2013 · Journal of Drug Delivery
Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease
Udita Chandola, R. Das, Binay Panda · 2014 · Briefings in Functional Genomics
Cancer: pathological nuclear reprogramming?
Colin R. Goding, Duanqing Pei, Xin Lü · 2014 · Nature reviews. Cancer
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
Jie Lan, Nicholas Rajan, Martin Bizet, Audrey Penning, Nitesh Kumar Singh, Diana Guallar, Emilie Calonne, Andrea Li Greci, Elise Bonvin, Rachel Deplus et al. · 2020 · Nature Communications
Modulation of Ten-Eleven Translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) Expression, α-Ketoglutarate (α-KG), and DNA Hydroxymethylation Levels by Interleukin-1β in Primary Human Chondrocytes
Abdul Haseeb, Mohammad Shahidul Makki, Tariq M. Haqqi · 2014 · Journal of Biological Chemistry
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis
Emily Ferguson Mason, Jason L. Hornick · 2013 · Modern Pathology
Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer
Peng Ding, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He et al. · 2018 · Clinical Epigenetics
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer
Santiago Uribe‐Lewis, Rory Stark, Thomas D. Carroll, Mark Dunning, Martin Bachman, Yoko Ito, Lovorka Stojic, Silvia Halim, Sarah L. Vowler, Andy G. Lynch et al. · 2015 · Genome biology
Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma
Xiaomei Gao, Yuan‐Yuan Sheng, Jing Liang Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun et al. · 2018 · Journal of Experimental & Clinical Cancer Research
Versatile Electroanalytical Bioplatforms for Simultaneous Determination of Cancer-Related DNA 5-Methyl- and 5-Hydroxymethyl-Cytosines at Global and Gene-Specific Levels in Human Serum and Tissues
Eloy Povedano, Víctor Ruiz‐Valdepeñas Montiel, Alejandro Valverde, Fernando Navarro-Villoslada, Paloma Yáñez‐Sedeño, Marı́a Pedrero, Ana Montero‐Calle, Rodrigo Barderas, Alberto Peláez‐García, Marta Mendiola et al. · 2018 · ACS Sensors
Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis
Antonella Carella, Juan Ramón Tejedor, María G. García, Rocío G. Urdinguio, Gustavo F. Bayón, Marta Sierra, Virginia López, Estela G. Toraño, Pablo Santamarina‐Ojeda, Raúl F. Pérez et al. · 2019 · International Journal of Cancer
Hypoxia and Oxygen-Sensing Signaling in Gene Regulation and Cancer Progression
Guang Yang, Rachel Shi, Qing Hua Zhang · 2020 · International Journal of Molecular Sciences
Roles and Regulations of TET Enzymes in Solid Tumors
Julie K. Bray, Meelad M. Dawlaty, Amit K. Verma, Anirban Maitra · 2021 · Trends in cancer
The protective role of DOT1L in UV-induced melanomagenesis
Bo Zhu, Shuyang Chen, Hongshen Wang, Chengqian Yin, Changpeng Han, Cong Peng, Zhaoqian Liu, Lixin Wan, Xiaoyang Zhang, Jie Zhang et al. · 2018 · Nature Communications
Portraits of TET-mediated DNA hydroxymethylation in cancer
Jana Jeschke, Évelyne Collignon, François Fuks · 2016 · Current Opinion in Genetics & Development
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment
Xingyi Pan, Lei Zheng · 2020 · Cellular and Molecular Immunology
Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma
Thilo Gambichler, Michael S. Sand, Marina Skrygan · 2013 · Melanoma Research
TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells
Zhongxue Ye, Jie Li, Xi Han, Huilian Hou, He Chen, Xia Zheng, Jiaojiao Lu, Lijie Wang, Wei Chen, Xu Li et al. · 2016 · Journal of Experimental & Clinical Cancer Research
Global DNA Methylation Patterns in Human Gliomas and Their Interplay with Other Epigenetic Modifications
Michał J. Dąbrowski, Bartosz Wojtaś · 2019 · International Journal of Molecular Sciences
Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer
John P. Thomson, Raffaele Ottaviano, Elif B. Unterberger, Harri Lempiäinen, Arne Müller, Rémi Terranova, Robert Scott Illingworth, Shaun Webb, Alastair R. W. Kerr, Marcus J. Lyall et al. · 2016 · Cancer Research
The TET enzymes
Peppi Koivunen, Tuomas Laukka · 2017 · Cellular and Molecular Life Sciences
Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation
Sevinci Pop, Ana‐Maria Enciu, Isabela Ţârcomnicu, Elvira Gille, Cristiana Tănase · 2019 · Phytochemistry Reviews
Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation
Brateil Badal, Alexander Solovyov, Serena Di Cecilia, Joseph Minhow Chan, Li‐Wei Chang, Ramiz Iqbal, Iraz T. Aydin, Geena Susan Rajan, Chen Chen, Franco Abbate et al. · 2017 · JCI Insight
Systematic Characterization of Autophagy in Gestational Diabetes Mellitus
Lulu Ji, Zhiguo Chen, Yating Xu, Guoping Xiong, Rui Liu, Chao Wu, Hanyang Hu, Lin Wang · 2017 · Endocrinology
Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways
Sanchari Bhattacharyya, Kith Pradhan, Nathaniel R. Campbell, Jozef Mazdo, Aparna Vasantkumar, Shahina Bano Maqbool, Tushar Damodar Bhagat, Sonal Gupta, Masako Suzuki, Yiting Yu et al. · 2017 · Genome Research
MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET–SOCS1–MMP9 signaling axis
Qing Chen, Dan Yin, Yong Zhang, Lei Yu, Xuedong Li, Zheng‐Jun Zhou, Shao‐Lai Zhou, Dongmei Gao, Jie Hu, Cheng S. Jin et al. · 2017 · Cell Death and Disease
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
Mayinuer Maitituoheti, Emily Zhi-Yun Keung, Ming Tang, Yan Liang, Hunain Alam, Guangchun Han, Anand Kamal Singh, Ayush T. Raman, Christopher J. Terranova, Sharmistha Sarkar et al. · 2020 · Cell Reports
Racial differences in genome-wide methylation profiling and gene expression in breast tissues from healthy women
Min‐Ae Song, Theodore M. Brasky, Cătălin Marian, Daniel Y. Weng, Cenny Taslim, Ramona Dumitrescu, Adana A. M. Llanos, Jo L. Freudenheim, Peter G. Shields · 2015 · Epigenetics
TET Family of Dioxygenases: Crucial Roles and Underlying Mechanisms
Duo Li, Bin Guo, Haijing Wu, Lina Tan, Qianjin Lu · 2015 · Cytogenetic and Genome Research
Epigenetic profiles as defined signatures of xenobiotic exposure
John P. Thomson, Jonathan G. Moggs, C. Roland Wolf, Richard R. Meehan · 2013 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation
Bo-Kuan Wu, Charles Brenner · 2014 · Cell Reports
Subcellular compartmentation of ascorbate and its variation in disease states
Gábor Bánhegyi, Angelo Benedetti, Éva Margittai, Paola Marcolongo, Rosella Fulceri, Csilla Emese Németh, András Szarka · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
TET3‐mediated DNA oxidation promotes ATR‐dependent DNA damage response
Dewei Jiang, Shu H. Wei, Fei Chen, Ying Zhang, Jiali Li · 2017 · EMBO Reports
DNA methylation/hydroxymethylation in melanoma
Siqi Fu, Haijing Wu, Huiming Zhang, Christine Guo Lian, Qianjin Lu · 2017 · Oncotarget
Oncogenic CDK13 mutations impede nuclear RNA surveillance
Megan L. Insco, Brian J. Abraham, Sara J. Dubbury, Ines H. Kaltheuner, Sofia Dust, Constance Wu, Kevin Y. Chen, David Liu, Stanislav Bellaousov, Anna M. Cox et al. · 2023 · Science
Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8
Yiqun Jiang, B Yan, W Lai, Yujiang Geno Shi, Di Xiao, J Jia, S Liu, Hongde Li, Jinping Lu, Z Li et al. · 2015 · Oncogene
Advances in the DNA methylation hydroxylase TET1
Wenzheng Liu, Guanhua Wu, Fei Xiong, Yongjun Chen · 2021 · Biomarker Research
A novel cancer-germline transcript carrying pro-metastatic miR-105 andTET-targeting miR-767 induced by DNA hypomethylation in tumors
Axelle E. Loriot, Aurélie Van Tongelen, Jordi Blanco, Simon Klaessens, Julie Cannuyer, Nicolas van Baren, Anabelle Decottignies, Charles De Smet · 2014 · Epigenetics
Compendium of aberrant DNA methylation and histone modifications in cancer
Naoko Hattori, Toshikazu Ushijima · 2014 · Biochemical and Biophysical Research Communications
Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma
Sahar Olsadat Sajadian, Sabrina Ehnert, Haghighat Vakilian, Eirini Koutsouraki, Georg Damm, Daniel Seehofer, Wolfgang Erwin Thasler, Steven Dooley, Hossein Baharvand, Bence Sipos et al. · 2015 · Clinical Epigenetics
Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function
Maxim Ivanov, Mart Kals, Marina Kacevska, Isabel Barragán, Kie Kasuga, Anders Rane, Andres Metspalu, Lili A. Milani, Magnus Ingelman‐Sundberg · 2013 · Genome biology
Oxygen regulation of TET enzymes
Rugilė Matulevičiūtė, Pedro P. Cunha, Randall S. Johnson, Iosifina P. Foskolou · 2021 · FEBS Journal
Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
Iva B. Zovkic, Jarrod P. Meadows, Garrett A. Kaas, J. David Sweatt · 2013 · Frontiers in Psychiatry
TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression
Yao-fei Pei, Ran N. Tao, Jianfang Li, Liping Su, Beiqin Yu, Xiongyan Wu, Min Yan, Qinlong Gu, Zhenggang Zhu, Bingya Liu · 2016 · Oncotarget
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer
Yong Yu, Jingjing Qi, Jieyi Xiong, Liping Jiang, Di Cui, Junlin He, Ping Chen, Lianjie Li, Chenjie Wu, Tonghui Ma et al. · 2019 · Theranostics
Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation
Rinho Kim, Karyn L. Sheaffer, Inchan Choi, Kyoung‐Jae Won, Klaus H. Kaestner · 2016 · Genes & Development
TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis
Min Deng, Ruixin Zhang, Zhengxi He, Qinwei Qiu, Xihong Lu, Jiang Yin, Hao Liu, Xiaoting Jia, Zhimin He · 2017 · Cancer Research
Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes
Shih-Han Kao, Kou‐Juey Wu, Wen‐Hwa Lee · 2016 · Journal of Clinical Medicine
Fisetin decreases TET 1 activity and CCNY / CDK 16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell
Yibing Si, Junfeng Liu, Hongliang Shen, Chen Zhang, Yuanhao Wu, Yongyi Huang, Zhangbin Gong, Jun Xue, Te Liu · 2018 · Journal of Cellular and Molecular Medicine
TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling
Xinchao Zhang, Shuyan Li, Jing He, Yunjie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou et al. · 2022 · Cancer Research
A primary role of TET proteins in establishment and maintenance ofDe Novobivalency at CpG islands
Lingchun Kong, Li Tan, Ruitu Lyu, Zhennan Shi, Lijun Xiong, Feizhen Wu, Kimberlie Rabidou, Michael Smith, Celestine He, Lei Zhang et al. · 2016 · Nucleic Acids Research
Genome‐wide promoter methylation analysis identifies epigenetic silencing of MAPK 13 in primary cutaneous melanoma
Linda Y. Gao, Marjon A. Smit, Joost J. van den Oord, Jelle J. Goeman, Els M.E. Verdegaal, Sjoerd H. van der Burg, Marguerite Stas, Samuel Beck, Nelleke A. Gruis, Cornelis P. Tensen et al. · 2013 · Pigment Cell & Melanoma Research
Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMESin human hepatocellular carcinoma
Fei Gao, Yudong Xia, Junwen Wang, Zhilong Lin, Ying Ou, Xing Liu, Weilong Liu, Boping Zhou, Huijuan Luo, Baojin Zhou et al. · 2014 · Genome biology
Rethinking the biology of metastatic melanoma: a holistic approach
Hendrik HLD Vandyck, Lisa Maria Hillen, Francesca Maria Bosisio, Joost van den Oord, Axel zur Hausen, Veronique J.L. Winnepenninckx · 2021 · Cancer and Metastasis Reviews
Perspectives of International Human Epigenome Consortium
Jae‐Bum Bae · 2013 · Genomics & Informatics
Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype
Kuo‐Wang Tsai, Guancheng Li, Chien‐Hsun Chen, Ming-Hsin Yeh, Jer‐Shyung Huang, Hui‐Hwa Tseng, Ting‐Ying Fu, Huei‐Han Liou, Hung‐Wei Pan, Shengfeng Huang et al. · 2015 · Breast Cancer Research and Treatment
Epigenetics and Oncology
Padmaja Mummaneni, Stacy Shifflett Shord · 2014 · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
The Application of Genome-Wide 5-Hydroxymethylcytosine Studies in Cancer Research
John P. Thomson, Richard R. Meehan · 2016 · Epigenomics
Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors
Allison R. Larson, Karen Dresser, Qian Zhan, Cecilia M. Lezcano, Bruce A. Woda, Benafsha Yosufi, John F. Thompson, Richard A. Scolyer, Martín C. Mihm, Yujiang Geno Shi et al. · 2014 · Modern Pathology
5-Hydroxymethylcytosine Profiling as an Indicator of Cellular State
Alexander Laird, John P. Thomson, David James Harrison, Richard R. Meehan · 2013 · Epigenomics
TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma
Asuka Murata, Yoshifumi Baba, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Kazuto Harada, Junji Kurashige, Shiro Iwagami, Yasuo Sakamoto, Yuji Miyamoto et al. · 2015 · Oncotarget
TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer
Christopher G. Chapman, Christopher J. Mariani, Feng Wu, Katherine R. Meckel, Fatma Ayaloglu Butun, Alice Chuang, Jozef Madžo, Marc B. Bissonnette, John H. Kwon, Lucy A. Godley · 2015 · Scientific Reports
Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas
Jonathan J. Lee, Lynette Marie Sholl, Neal Ian Lindeman, Scott R. Granter, Alvaro C. Laga, Priyanka Shivdasani, Gary Chin, Jason J. Luke, Patrick Alexander Ott, Frank Stephen Hodi et al. · 2015 · Clinical Epigenetics
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability
Jiantao Jia, Ying Shi, Ling Chen, Weiwei Lai, Bin Yan, Yiqun Jiang, Desheng Xiao, Sichuan Xi, Ya Cao, Shuang Liu et al. · 2017 · Theranostics
Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression
Francesco Mannavola, Stella D’Oronzo, Mauro Cives, Luigia Stefania Stucci, Girolamo Ranieri, Franco Silvestris, Marco Tucci · 2019 · International Journal of Molecular Sciences
Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation
Martin Lauss, Rizwan Haq, Helena Cirenajwis, Bengt Phung, Katja Harbst, Johan Staaf, Frida Rosengren, Karolina Holm, Mattias Aine, Karin Jirström et al. · 2015 · Journal of Investigative Dermatology
Mechanisms of Base Substitution Mutagenesis in Cancer Genomes
A. Bacolla, D. Cooper, Karen M. Vasquez · 2014 · Genes
Aberrant gene-specific DNA methylation signature analysis in cervical cancer
Samatha Bhat, Shama Prasada Kabekkodu, Vinay Koshy Varghese, Sanjiban Chakrabarty, Sandeep P. Mallya, Harish Rotti, Deeksha Pandey, Pralhad Kushtagi, Kapaettu Satyamoorthy · 2017 · Tumor Biology
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
Lorenzo Rinaldi, Alexandra Avgustinova, Mercè Martı́n, Debayan Datta, Guiomar Solanas, Neus Prats, Salvador Aznar Benitah · 2017 · eLife
5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease
Chaoran Dong, Jiemei Chen, Jilin Zheng, Yiming Liang, Yu Tao, Yupeng Liu, Feng Gao, Jie Long, Hangyu Chen, Qianhui Zhu et al. · 2020 · Clinical Epigenetics