Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

Lian, Christine Guo, Xu, Yufei, Ceol, Craig, Wu, Feizhen, Larson, Allison, Dresser, Karen, Xu, Wenqi, Tan, Li +23 more·2012·Cell

Cited by (811)

Items 601–700 of 811

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  2. Loss of 5‐hydroxymethylcytosine immunohistochemical expression is a useful diagnostic aid for distinguishing hepatocellular carcinoma in cytology fine needle aspiration specimens
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  3. A selective turn-on fluorescence strategy for the detection of 5-hydroxymethyl-2′-deoxycytidine
    Shengyong Yan, Xiaowei Xu, Pu Guo, Jianlin Hu, Changcheng Wang, Rong Huang, Xiaocheng Weng, Yuhao Du, Xiang Zhou · 2013 · RSC Advances
  4. TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
    Ziqing Yu, Lihua Zhong, Wangyang Tang, Wenfang Zhang, Ting Lin, Weifeng Zhu, Gang Chen, Jianchao Wang · 2025 · Clinical Epigenetics
  5. Ultraperformance Liquid Chromatography Tandem Mass Spectrometry Assay of DNA Cytosine Methylation Excretion from Biological Systems
    Jing Qu, Avinash Kumar, Yi‐Ming Liu, Oluwatoyin Veronica Odubanjo, Felicite Kamdem Noubissi, Yixin Hu, Hankun Hu · 2025 · ACS Omega
  6. Epigenetic dysregulation in cancers by isocitrate dehydrogenase 2 (IDH2)
    Anuraj Nayarisseri, Srinivas Bandaru, Arshiya Khan, Khushboo Sharma, Anushka Bhrdwaj, Manmeet Pal Kaur, Dipannita Ghosh, Ishita Chopra, Aravind Panicker, Abhishek Kumar et al. · 2024 · Advances in protein chemistry and structural biology
  7. Enhanced thermal stability enables human mismatch-specific thymine–DNA glycosylase to catalyse futile DNA repair
    Diana Manapkyzy, Botagoz Joldybayeva, Alexander A. Ishchenko, Bakhyt T. Matkarimov, Dmitry O. Zharkov, Sabira Taipakova, Murat K. Saparbaev · 2024 · PLoS ONE
  8. Reduction in immune cell number and loss of 5hmC are associated with lesion grade in cervical carcinogenesis
    Xiaohan Yang, Xinyue Shen, Zhujun Li, Wencai Li, Ying Liu · 2021 · 3 Biotech
  9. IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders (Review)
    Gong Ya, Shuang Wei, Yuan Wei, Yong Chen, Jian Tao Cui, Yue Yu, Xiang Lin, Hong Yan, Hui Qin, Lan Yi · 2022 · Oncology Letters
  10. 5hmC Immunohistochemistry: A Predictor of TERT Promoter Mutational Status in Follicular Thyroid Carcinoma?
    Martin Harper Hysek, L. Samuel Hellgren, Vincenzo Condello, Yiyi Xu, Catharina Larsson, Jan Zedenius, C. Christofer Juhlin · 2023 · Journal of Histochemistry & Cytochemistry
  11. 5-Methylcytosine immunohistochemistry for predicting cutaneous melanoma prognosis
    Jiraroch Meevassana, Shananya Varophas, Piyawan Prabsattru, Supitcha Kamolratanakul, Komkrit Ruangritchankul, Nakarin Kitkumthorn · 2024 · Scientific Reports
  12. TET3 downregulation and low 5-hydroxymethylcytosine are epigenetic signatures of head and neck carcinoma
    Jyoti Kanwar Shekhawat, Jyoti Sharma, Bikram Choudhury, Purvi Purohit, Praveen Sharma, Mithu Banerjee · 2024 · Molecular Biology Reports
  13. Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation
    Danielle Leavitt, Michael Wells, Phammela Abarzua, Gëorge F. Murphy, Christine Guo Lian · 2019 · Journal of Cutaneous Pathology
  14. ApcMin/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon
    Basetti Madhu, Santiago Uribe‐Lewis, Martin Bachman, Adele Murrell, John Richard Griffiths · 2020 · Scientific Reports
  15. Chromatin Memory in the Development of Human Cancers
    Yixin Yao · 2014 · Gene Technology
  16. Diagnostic implications of loss of 5-hydroxymethylcytosine for melanoma
    Christine Guo Lian, Gëorge F. Murphy · 2013 · Expert Review of Dermatology
  17. Epigenetic Modifications: Therapeutic Potential in Cancer
    Manisha Sachan, Manpreet Kaur · 2015 · Brazilian Archives of Biology and Technology
  18. Predicting and Monitoring Responses to Epigenetic Drugs
    Semira Sheikh, Mina Bekheet, Heidi Olzscha, Nicholas Barrie La Thangue · 2016 · Elsevier eBooks
  19. Epigenetics of Skin Disorders
    Shuaihantian Luo, Qianjin Lu · 2016 · Elsevier eBooks
  20. Transcriptomics and Epigenomics
    Preeti Chavan, Tejas Shah, Kalpana Joshi · 2016 · Elsevier eBooks
  21. Regulation of 5-Hydroxymethylcytosine Distribution by the TET Enzymes
    John Z. Cao, Anastasia E. Hains, Lucy A. Godley · 2019 · RNA technologies
  22. Epigenetics of Conjunctival Melanoma: Current Knowledge and Future Directions
    Kaylea M. Flick, Hakan Demirci, F. Yesim Demirci · 2024 · Cancers
  23. Epigenetic Dysregulation of 5-hydroxymethylcytosine in Well-Differentiated Pancreatic Neuroendocrine Tumors
    Aarti E. Sharma, Andrea Olivas, Megan Parilla, Lindsay Yassan, Hanlin Wang, Sharon S. Zhang, Christopher Weber, Xavier M. Keutgen, John Hart, Thomas Krausz et al. · 2021 · Applied immunohistochemistry & molecular morphology
  24. An Overview of Global, Local, and Base-Resolution Methods for the Detection of 5-Hydroxymethylcytosine in Genomic DNA
    Noa Erlitzki, Rahul M. Kohli · 2024 · Methods in molecular biology
  25. Effects of TET2-mediated methylation reconstruction on A2058 melanoma cell sensitivity to matrix stiffness in a 3D culture system
    Zhizhong Shen, Zixian Liu, Meng Li, Lu Han, Jianming Wang, Xunwei Wu, Shengbo Sang · 2024 · Experimental Cell Research
  26. PRAME Expression in Melanoma is Negatively Regulated by TET2-Mediated DNA Hydroxymethylation
    Rui Fang, Tuulia Vallius, Arianna Zhang, Devon Van Cura, Francisco Alicandri, Grant M. Fischer, Elizabeth C. Draper, Shuyun Xu, Roxanne J. Pelletier, Justina Wang et al. · 2024 · Laboratory Investigation
  27. cfDNA hydroxymethylcytosine profiling for detection metastasis and recurrence of Esophageal Squamous Cell Carcinoma
    Subinuer Kuerban, Hangyu Chen, Long Chen, Lei Zhang, Xuehui Li, Baixin Zhen, Hong Xiao, Yingzhu Chen, Haitao Zhou, Zhen Liang et al. · 2025 · World Journal of Surgical Oncology
  28. The combined diagnostic value of 5-hmC and PRAME immunohistochemistry in melanocytic neoplasms
    Yanhong Yu, Niloufar Hosseini, David W. Dodington, Kimberly Wood, Danny Ghazarian, Zaid Saeed Kamil · 2025 · Pathology - Research and Practice
  29. Epigenetic Factors: Key Regulators Targeted in Cancers
    Nicole Shu Ling Yeo-Teh, Yoshiaki Ito, Sudhakar Jha · 2018 · InTech eBooks
  30. Vitamin C: epigenetic roles and cancer
    Sushmita Mustafi, Gaofeng Wang · 2019 · Elsevier eBooks
  31. Proteomics and melanoma: a current perspective.
    Bradley D. Shields, Alan J. Tackett, Sara C. Shalin · 2016 · PubMed
  32. DNA Hydroxymethylation in the Regulation of Gene Expression in Human Solid Cancer
    Sofía Lizeth Alcaráz‐Estrada, Gabriela Leija-Montoya, Nicolás Serafín‐Higuera, Silvia Inés García, Claudia E. Millán-Testa, Mónica Sierra-Martínez, Magali Blanco-Morales, Jorge Sandoval-Basilio · 2020 · IntechOpen eBooks
  33. Ivosidenib for the treatment of relapsed or refractory acute myeloid leukemia with an IDH1 mutation
    Florence Pasquier, Claude Chahine, Christophe Marzac, Stéphane de Botton · 2020 · Expert Review of Precision Medicine and Drug Development
  34. M6A-Related Bioinformatics Analysis Reveals a New Prognostic Risk Signature in Cutaneous Malignant Melanoma
    Qingxiong Yu, Hainan Zhu, Huijing Wang, Rehanguli Aimaier, Manhon Chung, Zhichao Wang, Qingfeng Li · 2022 · Disease Markers
  35. 5‐Hydroxymethylcytosine is a useful marker to differentiate between dermatofibrosarcoma protuberans and dermatofibroma
    Yasutomo Mikoshiba, Eisaku Ogawa, Ryuhei Uchiyama, Aya Uchiyama, Hisashi Uhara, Ryuhei Okuyama · 2014 · Journal of the European Academy of Dermatology and Venereology
  36. Melanoma insights written in the DNA
    Darren J. Burgess · 2012 · Nature reviews. Cancer
  37. Epigenome-Wide Association Studies: Potential Insights into Human Disease
    Christopher G. Bell · 2013 · Springer eBooks
  38. DNA Methylation Changes in Cancer
    John P. Thomson, Richard R. Meehan · 2017 · Cancer drug discovery and develogment/Cancer drug discovery and development
  39. Defective 5-Methylcytosine Oxidation in Tumorigenesis
    Gerd P. Pfeifer, Seung‐Gi Jin · 2018 · Elsevier eBooks
  40. Aberrant epigenetic regulation of RARβ by TET2 is involved in cutaneous squamous cell carcinoma resistance to retinoic acid
    Xinyue Zhang, Cong Yan, Zhaowei Chu, Linjing Shi, Yi Zheng, Qiang Zhao, Songmei Geng, Kun Guo · 2022 · The International Journal of Biochemistry & Cell Biology
  41. Identification of Prognostic DNA Methylation Signatures in Lung Adenocarcinoma
    Pengli Wang, Gaoran Xu, Erji Gao, Yong Feng Xu, Leilei Liang, Gening Jiang, Liang Duan · 2022 · Oxidative Medicine and Cellular Longevity
  42. The Impact of The Hydroxymethyl-Cytosine Epigenetic Signature on DNA Structure And Function
    Federica Battistini, Pablo Daniel Dans, Montserrat Terrazas, Chiara Lara Castellazzi, Guillem Portella, Mireia Labrador, Núria Villegas, Isabelle Brun Heath, Carlos González, Modesto Orozco · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Low 5-hydroxymethylcytosine level is an independent predictor of high histological grade in locally advanced breast cancer
    D Prada, José Díaz‐Chávez, Omar Peña‐Curiel, M. T. T. Ramirez, E Colicino, Cynthia Mayte Villarreal-Garza, P.A. Cabrera-Galeana, Thania Castro-Belio, N Reynoso, Marco A. Andonegui et al. · 2020 · Journal of Cancer Research & Therapy
  44. Ten-eleven translocation 1 mediating DNA demethylation regulates the proliferation of chicken primordial germ cells through the activation of Wnt4/β-catenin signaling pathway
    Yinglin Lu, Ming Li, Heng Cao, Jing Zhou, Fan Li, Debing Yu, Minli Yu · 2024 · Animal Bioscience
  45. New insights into the structure and dynamics of the epigenetic modifications on DNA
    Dineshbabu Takkella, Javier Cerezo, Lara Martínez‐Fernández, Krishna Gavvala · 2025 · RSC Chemical Biology
  46. Reduced 5-hydroxymethylcytosine due to TET2 downregulation is associated with chondrosarcoma progression
    Hiroshi Furukawa, Takeshi Iwasaki, Kengo Kawaguchi, Hiroki Sonoda, Kenichi Kohashi, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda · 2025 · Scientific Reports
  47. 5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis
    Lei Zhang, Xiaotong Han, Xinran Gao, Hangyu Chen, Chunliang Shang, Long Chen, Jian Lin, Hongyan Guo · 2026 · EBioMedicine
  48. Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid
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  49. Chemical oxidation-free site-specific 5-hydroxymethylcytosine assay
    Lin Sun, Jingli Yan, Yi-Lin Liu, Ruipeng Wang, Yongqiang Cheng · 2021 · Sensors and Actuators B Chemical
  50. Understanding the Crosstalk Between Epigenetics and Immunometabolism to Combat Cancer
    Anuradha Seth, Susanta Kar · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
  51. Hydroxymethylation and Epigenetic Drugs: New Insights into the Diagnosis and Treatment in Epigenetics of Hepatocellular Carcinoma
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  52. Evaluation of tubulin β-3 and 5 hydroxy-methyl cytosine as diagnostic and prognostic markers in malignant melanoma
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  53. 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as potential diagnostic markers for breast cancer
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  54. Loss of ten-eleven translocation 2 (TET2) facilitates aggressive behaviour in cutaneous melanoma by inducing peroxisome proliferator-activated receptor-γ coactivator 1α expression and oxidative phosphorylation
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  55. Epigenetic Primer for Diagnostic Applications: A window into Personalized Medicine
    Beth A. McNally, Mark W. Linder, Roland Valdes · 2014 · Personalized Medicine
  56. Oxidized form of 5-methylcytosine - 5-hydroxymethylcytosine: a new insight into the biological significance in the mammalian genome
    Olga A. Efimova, Anna Andreyevna Pendina, Andrei V. Tikhonov, Tatyana Vladimirovna Kuznetzova, Vladislav Sergeyevich Baranov · 2014 · Ecological genetics
  57. Active DNA Demethylation in Development, Human Disease, and Cancer
    Rossella Tricarico, Alfonso Bellacosa · 2016 · Springer eBooks
  58. Introduction to Epigenetics
    Yu Liu, Qianjin Lu · 2015 · Elsevier eBooks
  59. Pathology and Molecular Pathology of Melanoma
    Amrita Goyal, Lyn McDivitt Duncan · 2016 · Springer eBooks
  60. Recent advancement toward significant association between disordered transcripts and virus-infected diseases: a survey
    Sagnik Sen, Ujjwal Maulik · 2018 · Briefings in Functional Genomics
  61. The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia
    Linlin Cao, Hangqi Liu, Zhihong Yue, Lin Pei, Hui Wang, Mei Jia · 2019 · Hematology
  62. Loss of Methylation Modification Marks the Presence of Psoriasis
    Brian C. Capell, John T. Seykora · 2020 · Journal of Investigative Dermatology
  63. Epigenetic Regulation in Melanoma
    Michelle Dang, Leonard Ira Zon · 2019 · Springer eBooks
  64. Methylation analysis highlights novel prognostic criteria in human‐metastasized melanoma
    Weiyang Cai, Xiaoxia Ding, Jingjing Li, Zhiming Li · 2019 · Journal of Cellular Biochemistry
  65. (Epi)genetic profiling of cutaneous melanoma: diagnostic, prognostic, and biological relevance
    Karin van den Hurk · 2015
  66. Analysis study and imaging on stepwise multi-photon activation fluorescence of melanin
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  67. Can Histone Proteins Promote the Growth of Melanoma?
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  68. The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single Cell Resolution
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  69. Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells
    Maki Ohya, Koh Nakazawa, Hiroyuki Kanno · 2018 · Pathology
  70. Decrease of 5-hydroxymethylcytosine in hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study
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  71. Nuclear-localized metabolic enzymes: emerging key players in tumor epigenetic regulation
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  72. In silico mapping of non-canonical DNA structures across the human ribosomal DNA locus
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  74. Insights from Genetic Models of Melanoma in Fish
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  80. 5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin
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  83. TET2 Is Downregulated in Early Esophageal Squamous Cell Carcinoma and Promotes Esophageal Squamous Cell Malignant Behaviors
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  86. Computational Analysis of Epigenetic Modifications in Melanoma
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  90. Distinct pattern of epigenetic DNA modification in leukocytes from patients with colorectal carcinoma and individuals with precancerous conditions, benign adenoma and inflammatory bowel disease – a link to oxidative stress
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  91. Genome-wide abundance of 5-hydroxymethylcytosine in breast tissue reveals unique function in dynamic gene regulation and carcinogenesis
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  95. Signaling Networks that Induce Melanomagenesis and Metastasis that can be Exploited for Therapeutic Benefit
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  96. Epigenetic basis for Tensin3 dysregulation in human renal cell carcinoma
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  99. Pesquisa de células-tronco tumorais em pacientes com linfoma não-Hodgkin
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  100. Epigenetic Dysregulation in Cutaneous Malignant Melanoma: Advancing Approaches to Diagnosis, Prognosis, and Therapeutic Targeting
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