The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes
Open accessAbstract
SUMMARY A defining feature of vertebrate immunity is the acquisition of immunological memory, which confers enhanced protection against pathogens by mechanisms that are incompletely understood. Here, we compared responses by virus-specific naive T cells (TN) and central memory T cells (TCM) to viral antigen challenge in lymph nodes (LNs). In steady-state LNs, both T cell subsets localized in the deep T cell area and interacted similarly with antigen-presenting dendritic cells. However, upon entry of lymph-borne virus, only TCM relocalized rapidly and efficiently toward the outermost LN regions in the medullary, interfollicular and subcapsular areas where viral infection was initially confined. This rapid peripheralization was coordinated by a cascade of cytokines and chemokines, particularly ligands for TCM-expressed CXCR3. Consequently, in vivo recall responses to viral infection by CXCR3-deficient TCM were markedly compromised, indicating that early antigen detection afforded by intranodal chemokine guidance of TCM is essential for efficient anti-viral memory.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 9×
“Among those, TCM are of particular interest because they have a greater capacity than TEM to persist in vivo, and they are also more efficient at mediating protective immunity because they have superior proliferative potential (Wherry et al., 2003).”
BackgroundInfluentialPreferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 2×
“The enhanced protection against reinfection afforded by TEM can be explained, at least in part, by their privileged access to tissues that are particularly vulnerable to repeated invasions by pathogens (Gebhardt et al., 2009; Irla et al., 2010; Masopust et al., 2001).”
BackgroundLineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Dufour, J. H., Dziejman, M., Liu, M. T., Leung, J. H., Lane, T. E., & Luster, A. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3195 · Cited by 1,075
Self-citationJunt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846
Self-citationMigratory properties of naive, effector, and memory CD8(+) T cells
Weninger, W., Crowley, M. A., Manjunath, N., & von Andrian, U. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.953 · Cited by 515
Cited by
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,059
Self-citationTissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“T cell reactivation within these LN barrier sites precipitates rapid detection, innate immune activation, and recruitment of CXCR3+ memory T cells, all of which likely contribute to accelerating pathogen control (Kastenmüller et al., 2013; Sung et al., 2012).”
BackgroundBachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre-Ulrich, A. H., Locati, M., Luster, A. D., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 850
Self-citationChow, M. T., Ozga, A. J., Servis, R. L., Frederick, D. T., Lo, J. A., Fisher, D. E., Freeman, G. J., Boland, G. M., & Luster, A. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.010 · Cited by 716
“The CXCR3 chemokine system also plays important roles in the positioning of T cells within secondary lymphoid organs and peripheral tissue, facilitating the interactions of T cells with antigen-loaded activated dendritic cells (DCs), promoting T cell activation and differentiation, as well as assisting the process of…”
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Metadata
- Authors
- Sung, J. H., Zhang, H., Moseman, E. A., Alvarez, D., Iannacone, M., Henrickson, S. E., de la Torre, J. C., Groom, J. R., Luster, A. D., & von Andrian, U. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 150
- Issue
- 6
- Pages
- 1249-1263
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165918521
- Cited by
- 229
- References
- 6
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sung, J. H., Zhang, H., Moseman, E. A., Alvarez, D., Iannacone, M., Henrickson, S. E., de la Torre, J. C., Groom, J. R., Luster, A. D., & von Andrian, U. H. (2012). Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes. Cell. https://doi.org/10.1016/j.cell.2012.08.015
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